Journal
CHEMOSPHERE
Volume 206, Issue -, Pages 376-386Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.05.005
Keywords
Chiral antibiotics; (fluoro)quinolones; Enantiomers; Chiral chromatography; Wastewater
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Funding
- European Union's Seventh Framework Programme for Research, Technological Development and Demonstration [317205]
- NERC Project on 'Impact of stereochemistry of antimicrobial agents on their environmental fate, biological potency and the emergence of resistance' [NE/N019261/1]
- NERC [NE/N019261/1] Funding Source: UKRI
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This paper aims to examine the multiresidue enantiomeric profiling of (fluoro)quinolones and their metabolites in solid and liquid environmental matrices using chiral HPLC-MS/MS method and a CHIR-ALCEL (R) OZ-RH column. Simultaneous chiral separation was obtained for chiral ofloxacin and its main metabolites ofloxacin-N-oxide and desmethyl-ofioxacin; moxifloxacin; the prodrug prulifloxacin and its active compound ulifloxacin; flumequine; nadifloxacin and R-(+)-besifloxacin. Achiral antibiotics (ciprofloxacin, norfloxacin and nalidixic acid) were also included in the method to enable the analysis of all targeted quinolones within one analytical run. Satisfactory enantiomeric resolution (Rs >= 1) was obtained for five out of eight chiral drugs enabling quantitative analysis. The overall performance of the method was satisfactory with a method precision <20%, relative recoveries >70% for most of the analytes and method detection limits (MDL) at low ng L-1 levels (0.1 < MDL (ng L-1)< 6.4, 0.1 < MDL (ng L-1)< 6.6 and 0.1
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