Article
Environmental Sciences
Benfeng Cao, Can Fang, Xiaolin Peng, Xiaoqin Li, Xueting Hu, Pan Xiang, Li Zhou, Hongjie Liu, Yue Huang, Qin Zhang, Shan Lin, Mengke Wang, Yang Liu, Taoping Sun, Sijing Chen, Zhilei Shan, Jiawei Yin, Liegang Liu
Summary: This study aimed to investigate the association of plasma cobalt with newly diagnosed type 2 diabetes (T2D) and explore potential interaction effects between cobalt and other redox metals. The results indicated a U-shaped relationship between T2D and plasma cobalt levels, with significant interaction effects observed with copper. Higher or lower concentrations of plasma cobalt were associated with increased odds of T2D, highlighting the importance of studying the inter-relationships among redox metals in the context of T2D.
Article
Biochemistry & Molecular Biology
Belinda J. Dunning, Arno R. Bourgonje, Marian L. C. Bulthuis, Jan Alexander, Jan O. Aaseth, Anders Larsson, Harry van Goor, Urban Alehagen
Summary: This study aimed to evaluate the effect of supplementation with selenium and coenzyme Q10 on serum free thiols and to study associations with the risk of cardiovascular mortality in elderly community-dwelling individuals. The results showed that supplementation with selenium and coenzyme Q10 significantly improved serum free thiol levels and reduced the risk of cardiovascular mortality in elderly individuals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Noble, Matthew Guille, James N. Cobley
Summary: Measuring protein thiol redox state is crucial for understanding redox signaling in health and disease. Developing a microplate assay, like the Antibody-Linked Oxi-State Assay (ALISA), enables greater accessibility and advancement in the field of protein thiol redox biology. ALISA is a high throughput, time- and cost-efficient method that can help researchers study specific redox states of proteins in various biological processes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Meytal Radzinski, Tal Oppenheim, Norman Metanis, Dana Reichmann
Summary: Protein homeostasis and redox regulation are closely connected, with redox-regulated proteins or thiol-based switches at the core. Research discusses the redox code of the proteostasis network and evolving strategies of antioxidant proteins under oxidative stress conditions. The importance of cysteine in protein degradation is also highlighted.
Article
Biochemistry & Molecular Biology
Arjan de Groot, Laurence Blanchard, Nicolas Rouhier, Pascal Rey
Summary: Deinococcus species have remarkable tolerance to oxidative damage in extreme environmental conditions. Thiol reductases (TRs) play important roles in metabolism regulation and stress responses. The study reveals that Deinococcus possesses multiple enzyme systems that protect proteins and maintain redox status. Recent research further confirms the importance of TRs in Deinococcus' tolerance to oxidative treatments.
Article
Environmental Sciences
Yan-Mei Zhang, Chen -Yang Lin, Bang-Ze Li, Yuan-Xin Cheng, Wen -Bin Xu, Yi Xiao, Da -Yong Chen, Wei-Ren Dong, Miao-An Shu
Summary: This study investigated the effects of different concentrations of selenium on the toxicity and bioaccumulation of cadmium in mud crabs. The results showed that selenium can alleviate the damage caused by cadmium accumulation, improve antioxidant activity, and reduce stress response in the crabs. This study provides a better understanding of the impact of environmental toxins on estuary crustaceans.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Javed Ahmad, Rubina Yasmeen, Mohammad Irfan, Asma A. Al-Huqail, Mohammad Irfan Qureshi
Summary: Traces of arsenic in vegetables and crops cultivated in arsenic-polluted soils are a global concern due to its carcinogenic properties and harmful effects on the food chain. This study focused on the accumulation and defense mechanisms of fenugreek plants exposed to arsenic stress. The findings showed increased oxidative stress and DNA damage at higher arsenic concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Plant Sciences
Lara Vogelsang, Karl-Josef Dietz
Summary: This study investigates the regeneration specificity of thiol-dependent peroxiredoxins and glutathione peroxidase-like enzymes in the cytosol of Arabidopsis thaliana cells. The results demonstrate redundancy and specificity in the redox regulatory network of the cytosol, providing insights into the role of thioredoxins in this process.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Biochemistry & Molecular Biology
David J. Muggeridge, Daniel R. Crabtree, Ahmet Tuncay, Ian L. Megson, Gareth Davison, James N. Cobley
Summary: New readily accessible systemic redox biomarkers are needed to understand the biological roles reactive oxygen species (ROS) play in humans. The study used a maximal exercise bout to disrupt redox homeostasis and determine a candidate systemic redox biomarker in human erythrocytes. The results showed that the oxidation level of a specific phosphatase decreased during exercise, and the activity of the phosphatase was greater at rest compared to exercise.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xavier Forceville, Pierre Van Antwerpen, Jean-Charles Preiser
Summary: Sepsis is a severe health disaster that is difficult to control early on. Key events in disease progression include cell activation, damage, and reduced antioxidant enzyme concentration, as well as increased production of white blood cells and nitric oxide damage.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Plant Sciences
Muchamad Muchlas, Bok-Rye Lee, Md Al Mamun, Van Hien La, Sang-Hyun Park, Dong-Won Bae, Tae-Hwan Kim
Summary: This study aimed to investigate the effects of drought priming on oxidative burst signaling and hormone regulation in the GSH pathway and GSH-based redox control. The results showed that drought priming reduced the oxidative stress and lipid peroxidation during subsequent drought period. Drought priming activated the SA-mediated modulation of the GSH pathway and GSH redox control in antagonism with ABA responses.
PLANT GROWTH REGULATION
(2023)
Article
Biochemistry & Molecular Biology
Milica Manojlovic-Stojanoski, Slavica Borkovic-Mitic, Natasa Nestorovic, Natasa Ristic, Svetlana Trifunovic, Magdalena Stevanovic, Nenad Filipovic, Aleksandar Stojsavljevic, Sladan Pavlovic
Summary: Selenium is an essential element for normal cellular functioning, but low status and high concentrations can both increase oxidative stress. This study compared the effects of selenium nanoparticles and inorganic sodium selenite supplementation on pregnant rats. The results showed that selenium nanoparticles increased fetal lethality and changed antioxidant defense parameters in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Paula Mondragon, Sungmin Hwang, Lakshmi Kasirajan, Rebecca Oyetoro, Angelina Nasthas, Emily Winters, Ricardo L. Couto-Rodriguez, Amy Schmid, Julie A. Maupin-Furlow
Summary: This study identifies a TrmB-like protein (OxsR) that functions as a thiol-based transcriptional regulator in response to oxidative stress, particularly hypochlorite stress. OxsR binds to specific regions of DNA during hypochlorite stress, which are proximal to oxidative stress operons. Further analysis reveals that OxsR acts as both a transcriptional activator and repressor during hypochlorite stress. The presence of a conserved cysteine residue and a CG-rich motif in the promoter region suggests a widespread redox signaling mechanism in archaea.
Article
Cell Biology
Wei-Lun Hsu, Chieh-Min Wang, Chao-Ling Yao, Ssu-Ching Chen, Chung-Yi Nien, Yang-Ho Sun, Tsung-Yu Tseng, Yueh-Hsia Luo
Summary: The selenocompound SeC selectively attacks Nrf2-addicted colorectal cancer cells by reducing Nrf2 and autophagy pathway protein expression, resulting in cell death.
CELL DEATH & DISEASE
(2022)
Article
Microbiology
Xinrong Zhang, Zhenhua Zhang, Xiao-Lin Chen
Summary: Redox modification plays significant roles in plant pathogenic fungi, impacting various biological and cellular functions, such as fungal growth and pathogenicity. The global thiol proteome survey in Magnaporthe oryzae provides valuable insights for future studies on redox modification in fungi.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
S. Amuno, K. Shekh, V. Kodzhahinchev, S. Niyogi, A. Al Kaissi
Summary: The City of Yellowknife in Canada is known for arsenic contamination, with local wildlife near the abandoned Giant Mine showing signs of decreased bone mineralization and bone disorders. A study on muskrats and red squirrels in three catchment areas at different distances from the mine found higher levels of arsenic and cadmium in their bones closer to the site. Various bone lesions were observed in the animals, with muskrats showing significant correlation between arsenic content and percent fat in femur samples.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Ankur Jamwal, Vikas Phulia
Summary: The COVID-19 pandemic has significantly impacted aquaculture and capture fisheries in various aspects including production, supply chain, and consumer behavior. The global economy has suffered due to the pandemic, leading to reduced disposable income and potentially affecting fish sales. Therefore, the pandemic has wide-ranging socio-economic consequences beyond its medical implications.
FISH AND FISHERIES
(2021)
Review
Environmental Sciences
Arash Salahinejad, Anoosha Attaran, Denis Meuthen, Douglas P. Chivers, Som Niyogi
Summary: Antidepressant drugs entering aquatic ecosystems may have adverse effects on aquatic organisms, and comprehensive reviews are needed to explore possible causes behind contradictory research results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Neeraj Kumar, Dilip Kumar Singh, Shashi Bhushan, Ankur Jamwal
Summary: The study investigated the effects of a novel dietary combination of selenium nanoparticles and omega-3-fatty acids on mitigating arsenic pollution, high-temperature stress, and bacterial infection in Pangasianodon hypophthalmus. Results showed that supplementation with Se-NPs at 0.2 mg kg(-1) diet and EPA + DHA at 0.2% and 0.4% reduced primary stress levels, enhanced antioxidant enzymes and immunity, and decreased arsenic bioaccumulation in fish tissues. Overall, the combination of Se-NPs and EPA + DHA demonstrated potential in alleviating stress factors and improving growth performance in P. hypophthalmus.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Vikas Phulia, Parimal Sardar, Ankur Jamwal, Vikas Kumar, N. Shamna, Femi J. Fawole, Bhushan N. Sanap, N. P. Sahu, Subodh Gupta
Summary: The study focused on detoxifying non-edible Jatropha curcas kernel meal through various methods such as electron beam radiation and solvent extraction, successfully removing the major toxic component phorbol esters. The fermentation approach was found to be the most cost-effective, environmentally sustainable, and efficient method for detoxification.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Environmental Sciences
Arash Salahinejad, Anoosha Attaran, Denis Meuthen, Mahesh Rachamalla, Douglas P. Chivers, Som Niyogi
Summary: Recent studies have found that exposure to bisphenol S (BPS) can have multiple adverse effects on organisms. This study exposed adult female zebrafish to environmentally relevant concentrations of BPS and found that maternal exposure affected the social behavior and anxiety response of male offspring in a dose-specific manner. The impaired social behavior was associated with changes in neuropeptide signaling pathways in the brain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Syed Afroz Ali, Sumadhura Bommaraju, Jayant Patwa, Puja Khare, Mahesh Rachamalla, Som Niyogi, Ashok Kumar Datusalia
Summary: Copper-induced cardiac injury is not widely reported, but it can cause oxidative damage and tissue injury. Melatonin treatment showed protective effects against copper-induced cardiac injury by reducing oxidative variables, improving histological changes, decreasing tissue copper levels, and increasing antioxidant capacity. The therapeutic potential of melatonin in the treatment of cardiac injury and tissue fibrosis was demonstrated.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Environmental Sciences
Mahesh Rachamalla, Joshi Chinthada, Sapana Kushwaha, Sravan Kumar Putnala, Chittaranjan Sahu, Gopabandhu Jena, Som Niyogi
Summary: Arsenic is a toxic metalloid that is harmful to both humans and animals. Drinking water contaminated with arsenic has been linked to the development of various diseases, including cancer, diabetes, cardiovascular disease, and neurological damage. Arsenic exposure negatively affects male reproductive systems, leading to infertility, sexual dysfunction, and poor sperm quality.
Article
Marine & Freshwater Biology
Vladimir Kodzhahinchev, Kamran Shekh, Aditya Manek, Lynn P. Weber, Som Niyogi
Summary: This study aimed to investigate the uptake rate of cadmium and benzo[a]pyrene in fish. The results showed that simultaneous exposure to both toxicants increased the uptake rate of cadmium in the gills and the uptake rate of benzo[a]pyrene at the whole-body level.
AQUATIC TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Arun Kumar, Mohammad Ali, Vivek Raj, Arti Kumari, Mahesh Rachamalla, Som Niyogi, Dhruv Kumar, Ashok Sharma, Amit Saxena, Ghanish Panjawani, Preeti Jain, Ajay Vidyarthi, Navin Kumar, Mukesh Kumar, Pintoo Kumar Niraj, Md. Samiur Rahman, Akhouri Bishwapriya, Ranjit Kumar, Maiko Sakamoto, Santosh Kumar, Manisha Singh, Ashok Kumar Ghosh
Summary: In recent times, there has been a significant increase in the incidence of gallbladder cancer in India, particularly in arsenic hotspots identified in Bihar. This study aimed to establish a link between arsenic exposure and gallbladder carcinogenesis. The findings showed a significantly higher concentration of arsenic in the biological samples of gallbladder cancer patients, indicating a strong association between arsenic contamination and increased risk of gallbladder cancer.
SCIENTIFIC REPORTS
(2023)
Article
Marine & Freshwater Biology
Vladimir Kodzhahinchev, Mahesh Rachamalla, Ahmad Al-Dissi, Som Niyogi, Lynn P. Weber
Summary: This study aimed to investigate the effects of environmentally relevant concentrations of cadmium (Cd) and Benzo[a]Pyrene (BaP) on adult zebrafish. The results showed that exposure to the mixture of Cd and BaP led to extensive modulation of antioxidant and detoxification gene expression, as well as cardiac dysfunction in a tissue-specific manner.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Mahesh Rachamalla, Arash Salahinejad, Maria Khan, Ashok Kumar Datusalia, Som Niyogi
Summary: The study aimed to evaluate the effects of chronic dietary arsenic exposure on the cognitive performance of adult zebrafish and uncover the possible mechanisms behind these neurotoxic effects. The results showed that dietary treatment with arsenic significantly impaired the fish's performance in various latent learning tasks. Chronic dietary exposure to arsenic also increased arsenic accumulation and dopamine levels, and induced oxidative stress in the zebrafish brain. The study suggests that chronic environmentally relevant dietary exposure to arsenic can impair cognitive performance in zebrafish by inducing oxidative stress and disrupting dopaminergic neurotransmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Nilesh Anil Pawar, Chandra Prakash, Mahinder Pal Singh Kohli, Ankur Jamwal, Rishikesh Subhashrao Dalvi, B. Nightingale Devi, Soibam Khogen Singh, Shobha Gupta, Smit Ramesh Lende, Sadanand D. Sontakke, Subodh Gupta, Sanjay Balkrishna Jadhao
Summary: To achieve antibiotic-free aqua farming in the subcontinent, alternatives for species diversification from major to minor carps were sought. An experiment was conducted to investigate the efficacy of fructooligosaccharide (FOS) and Bacillus subtilis (BS) in promoting growth and immunity in Labeo fimbriatus fingerlings. The results showed that BS, not FOS, significantly improved growth and feed utilisation attributes. The combination of FOS and BS yielded synergistic effects and led to the highest improvement in immune functions and disease resistance.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Buddhadev Ghosh, Pratap Kumar Padhy, Soumya Niyogi, Pulak Kumar Patra, Markus Hecker
Summary: This study investigates the distribution of particle-bound heavy metals and associated health risks in different regions in West Bengal, India. The results reveal high concentrations of heavy metals in industrial areas, exceeding the risk limits. The study also identifies different sources of heavy metal pollution and calculates additional cancer cases in each region.
Article
Environmental Sciences
Parthasarathi Chakraborty, Aditya Manek, Sucharita Chakraborty, Jeff Hudson, Som Niyogi
Summary: An in vitro study investigated the impact of UV exposure on metal-dissolved humic material (M-DHM) complexes in aqueous systems at different pH. Higher pH led to increased complexation reactions between dissolved metals (Cu, Ni, and Cd) and DHM. UV radiation affected the chemical speciation of M-DHM complexes at different pH, increasing their lability and bioavailability in aquatic environments. The research findings have important implications for understanding the leachability of DHM from soil and its effects on dissolved metal concentrations in water bodies as well as the fate of M-DHM complexes in tropical marine/freshwater systems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)