Article
Materials Science, Multidisciplinary
Tianhang Song, Huilong Liu, Jun Ren, Zhongwen Wang
Summary: Research on thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP) materials has gained attention due to their widespread applications. However, obtaining organic TADF and RTP materials with stimulus-responsiveness and tunability is challenging and rarely reported. In this study, two easily synthesized organic molecules, PTZ-DBQ and BPTZ-DBQ, showed abnormal stimulus-responsive switchable TADF and RTP effects. These materials have potential applications in chemical sensors, information encryption, and anti-counterfeiting.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Tao Wang, Zhubin Hu, Xiancheng Nie, Linkun Huang, Miao Hui, Xiang Sun, Guoqing Zhang
Summary: Aggregation-induced emission (AIE) is a successful strategy for achieving highly efficient room temperature phosphorescence (RTP) by limiting molecular motions. In this study, the authors demonstrate a novel design strategy by combining AIE and donor-acceptor motifs to achieve unusual thermochromic dual phosphorescence.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xinrui Liu, Liuqing Yang, Xuefei Li, Lei Zhao, Shumeng Wang, Zheng-Hong Lu, Junqiao Ding, Lixiang Wang
Summary: A novel electroactive room-temperature phosphorescence (RTP) polymer with significant RTP characteristics in solid states has been developed, showing a record-high external quantum efficiency of 9.7% in electrophosphorescence. This performance surpasses the theoretical limit for typical fluors, suggesting potential for efficient pure organic light-emitting diodes in the future.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Daniela Cappello, Francis L. Buguis, Joe B. Gilroy
Summary: Molecular materials with pi-conjugated donor-acceptor and acceptor-donor-acceptor structures have versatile applications in organic photovoltaic materials, organic light-emitting diodes, and biological imaging agents. Boron-containing compounds with unique optoelectronic and redox properties are synthesized using Stille cross-coupling chemistry. The compounds exhibit reversible redox waves, solid-state emission, and aggregation-induced emission. The optical band gaps determined from experiments and density functional theory calculations support the rationalization of the observed optoelectronic properties. This study provides a foundation for incorporating these boron-containing compounds into applications that require fine-tuning of band gaps.
Article
Nanoscience & Nanotechnology
Biao Zhao, Shenghua Yang, Xueyong Yong, Jianping Deng
Summary: The study presents a simple strategy to achieve ultralong RTP emission in biobased nonconjugated polymers through a hydrolyzation process. The polymers synthesized exhibit enhanced blue emission and persistent RTP, with reversible emission performance regulated by cations or substituents. The obtained polymers show potential applications in anticounterfeiting and information encryption.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Levani Skhirtladze, Karolis Leitonas, Audrius Bucinskas, Kai Lin Woon, Dmytro Volyniuk, Rasa Keruckiene, Malek Mahmoudi, Mieczyslaw Lapkowski, Azhar Ariffin, Juozas Grazulevicius
Summary: A series of compounds with different donor moieties and 1,4-difluorobenzene unit as the acceptor were developed for optical sensors of oxygen. One compound, 2PS-2FPh, exhibited high sensitivity to low concentration of oxygen and showed strong room-temperature phosphorescence in a rigid matrix Zeonex. The increased molecular heterogeneity and the transformation of the hybrid local and charge transfer triplet state into locally excited triplet states were found to be the reasons for the high oxygen sensitivity of 2PS-2FPh.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
Chunguang Zhai, Xiu Yin, Shifeng Niu, Mingguang Yao, Shuhe Hu, Jiajun Dong, Yuchen Shang, Zhigang Wang, Quanjun Li, Bertil Sundqvist, Bingbing Liu
Summary: Developing a universal strategy to design piezochromic luminescent materials with desirable properties remains challenging. Here, the authors report the insertion of a non-emissive molecule into a donor and acceptor binary cocrystal and realize desirable piezochromic luminescent properties by manipulation of intermolecular interactions between the donor and acceptor molecules. This strategy allows for continuous pressure-induced emission enhancement and blue shift in the emission wavelength.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Hui Liu, Kun Zhang, Peng-Fu Gao, Jia-Hua Luo, Yu-Ying Jiang, Meng-Shu Zhou, Ting Li, Xue-Li Zhu, Hong-Ru Fu
Summary: Two Cd-based supramolecular coordination polymers with multiple luminescence emissions, including fluorescence and time- and temperature-dependent ultralong phosphorescence, have been successfully synthesized. One of the compounds exhibits a long-lived afterglow under ambient conditions, while the other shows nearly pure white-light emission. This is the first example of a luminescent coordination polymer with single-phase white-light emission and color-evolution RTP.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Suguru Ito, Sayaka Nagai, Takashi Ubukata, Takashi Tachikawa
Summary: This study introduces a new organic crystal dye that achieves both bicolor and tricolor mechanochromic luminescence effects, demonstrating that the emission color of crystals is influenced by molecular structures and packing arrangements.
Article
Materials Science, Multidisciplinary
Liu Ding, Xilang Jin, Yuchong Gao, Jinlong Wu, Taotao Ai, Hongwei Zhou, Xinyu Chen, Xinyu Zhang, Weixing Chen
Summary: In this study, a new class of carbon dots (E-CCDs) with reversible luminescence and room-temperature phosphorescence (RTP) behavior were successfully synthesized using an eco-friendly, low-cost one-pot solvothermal method. These E-CCDs exhibit dual emission spectra from different emission centers and the addition of cyanic acid enhances their RTP behavior.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xiaoya Zhao, Bo Wu, Xingtang Xu, Guojie Wang
Summary: A novel strategy for enhancing ultra-long room temperature phosphorescence (URTP) is reported by doping ground-state intermolecular donor-acceptor complexes into a dense polymer network. This strategy increases URTP by ensuring formation of intermolecular donor-acceptor complexes and suppressing non-radiative relaxation. The URTP intensity and phosphorescence lifetime of the doped film are significantly improved compared to the film doped with acceptor molecules only. The photophysical mechanism and rationality of the strategy are confirmed by theoretical calculations, and an advanced encryption application based on enhanced URTP films is developed.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Applied
Dan Hong, Xian-yue Xiang, Qiu-ju Zhou, Yu-Lin Zhu, Yong-ping Wu, Jun Yang, Shi-hong Chen, Ke-jun Tan
Summary: In this study, multi-emission carbon dots (M-CDs) with three emissions were synthesized and their luminescence mechanism was investigated in detail. The high-concentration M-CDs showed emissions at 423 nm and 586 nm, while the emission at 493 nm was mainly due to self-absorption. On the other hand, low-concentration M-CDs only had emissions at 423 nm and 586 nm. Solid CDs (S-CDs) with solid-state room temperature phosphorescence (RTP) were also obtained, and their mechanism was found to be related to the presence of NaHCO3 acting as an oxygen barrier. The M-CDs were successfully used for detecting Morin, while the S-CDs were applied for optical anti-counterfeiting purposes.
Article
Biochemistry & Molecular Biology
Patrycja Filipek, Hubert Hellwig, Agata Szlapa-Kula, Michal Filapek
Summary: Latent fingerprints are an important carrier of information for court experts. This research aimed to find an easy-to-use, compact, and versatile method to detect hidden fingerprints, and explored the physicochemical properties of luminescent substances for potential use. The study found that a group of synthesized compounds showed promising features in detecting latent fingerprints.
Article
Chemistry, Physical
Yuanyuan Chong, Xiaolong Zhang, Biao Chen, Ran Liu, Ziye Wu, Guoqing Zhang, Jun Jiang, Shaul Mukamel, Guozhen Zhang
Summary: In this study, it was demonstrated that using azobenzene as a photoswitch can enhance charge separation and intersystem crossing in organic long persistent luminescence materials, leading to improved performance of devices. The theoretical findings may contribute to the design of long persistent luminescent organic devices.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Chemistry, Physical
Yongyan Zhou, Zhiwen Yang, Zhipeng Qiu, Nian Tang, Dongwei Sun, Bo Liu, Xiaohui Wu, Shaomin Ji, Wen-Cheng Chen, Yanping Huo
Summary: Aggregation-induced emission (AIE) offers a solution to harvest strong solid-state fluorescence, which is crucial to achieving efficient organic light-emitting diodes (OLEDs). In this study, two novel AIE luminogens (AIEgens) were designed by integrating the advantages of triphenylamine (TPA) and phenanthroimidazole (PI), which exhibited excellent electron-donating ability of TPA and bipolar characteristics and suitable carrier transporting ability of PI. The ratio of intramolecular and intermolecular charge transfer can be controlled to achieve emission adjustability. A non-doped OLED based on one of the AIEgens demonstrated high external quantum efficiency and low turn-on voltage, showing great potential for OLED applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wei Jiang, Wang Dong, Min Li, Zixuan Guo, Qin Wang, Yi Liu, Yihui Bi, Han Zhou, Yucai Wang
Summary: The study shows that the gaseous molecule nitric oxide (NO) can induce immunogenic cell death (ICD) in tumor cells, triggering a protective immune response.
Article
Materials Science, Multidisciplinary
Xiancheng Nie, Jiajun Du, Wenhuan Huang, Tao Wang, Xiao Wang, Biao Chen, Xuepeng Zhang, Guoqing Zhang
Summary: Organic room-temperature phosphorescent (RTP) materials play an important role in optical imaging and sensing technologies. However, the excitation requirements and potential photo damage limit their practical applications. In this study, a new design concept using dihydroxy-functionalized naphthalenediimide (NDI) is demonstrated to achieve visible light absorption and near-infrared RTP. The resulting polymer NDI-PLA2/NDI-PCL2 exhibits long lifetimes and offers potential for expanding to other molecular RTP systems.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Guorong Zhang, Qin Wang, Wanyin Tao, Wei Jiang, Eran Elinav, Yucai Wang, Shu Zhu
Summary: Encapsulating antibiotics in orally administered positively charged polymeric nanoparticles with a glucosylated surface improves absorption in the proximal small intestine and limits exposure to flora in the large intestine.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Li Wang, Jiaxiang Dou, Wei Jiang, Qin Wang, Hang Liu, Yucai Wang, Yi Liu
Summary: This study discovered that the pyknomorphic extracellular matrix (ECM) acts as a barrier to impede the active transcytosis of nanoparticles in tumors. However, degradation of the ECM's pivotal constituent, collagen, effectively enhances intracellular transcytosis. Specifically, a collagenase conjugating transcytosis nanoparticle (Col-TNP) can dissociate into collagenase and cationized gold nanoparticles in the tumor's acidic environment, enabling their ECM tampering ability and active transcytosis in tumors.
Article
Chemistry, Multidisciplinary
Wei Jiang, Zhiqiang Shen, Zixuan Guo, Qin Wang, Quan Li, Jinming Hu, Yucai Wang
Summary: In this study, smart materials capable of adapting to the pathological oxygen levels in tumors were developed to enhance cancer immunotherapy. These materials generate immunogenic stimuli that induce immunogenic cell death, stimulate dendritic cell maturation, and increase the infiltration of cytotoxic T cells into tumors, thus overcoming the oxygen heterogeneity in tumors and boosting immunotherapy.
Article
Nanoscience & Nanotechnology
Chang Xie, Li Wang, Yajuan Liu, Muqing Chen, Pingwu Du, Yucai Wang, Xiaopeng Ma, Shangfeng Yang
Summary: Photothermal therapy (PTT) using near-infrared-II (NIR-II) light is an effective tumor therapy technique with deeper tissue penetration and higher laser power density. Black phosphorus (BP) has potential applications in PTT, but its low stability and limited photothermal conversion efficiency pose challenges. In this study, fullerene covalently modified few-layer BP nanosheets (BP-ester-C60) were developed to enhance stability and photothermal conversion efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yi Liu, Wang Dong, Yinchu Ma, Jiaxiang Dou, Wei Jiang, Li Wang, Qin Wang, Shuya Li, Yucai Wang, Min Li
Summary: Tumor hypoxia heterogeneity, a characteristic feature of the tumor microenvironment, leads to resistance to chemotherapy. To overcome this, a nanomedicine called NPHPaPN was developed, which utilizes hypoxia-responsive PEG shell deshielding and drug internalization through the HA-CD44 pathway to target cisplatin-resistant tumor cells. The release of cisplatin prodrug and a DNA damage repair inhibitor within the tumor cells enhances drug sensitivity and leads to significant tumor growth suppression with an inhibition rate of approximately 84.4%.
Article
Chemistry, Multidisciplinary
Youcui Xu, Chang Yang, Yi Wu, Wei Jiang, Quan Cheng, Lifeng Yan, Kaige Chen, Yucai Wang
Summary: Researchers have developed a fluorescent probe called IR1080 to detect micrometastases in cancer patients, which can be used for fluorescence image-guided surgery. IR1080 binds rapidly to albumin in plasma, resulting in increased fluorescence brightness. It also has a high affinity for SPARC, an albumin-binding protein overexpressed in micrometastases. The interaction between SPARC and IR1080 leads to a high detection rate and accurate delineation of tumor margins, making IR1080 an efficient strategy for the diagnosis and image-guided surgery of micrometastases.
Article
Chemistry, Multidisciplinary
Min Li, Han Zhou, Namei Wu, Wuxian Deng, Wang Dong, Xun Sun, Hang Liu, Zhigang Tian, Yucai Wang
Summary: We describe a novel bacterial nanomedicine (BNM) system for pathogen recognition-mediated DCs-specific gene silencing and gene editing. The targeting efficiency of BNMs is reduced in DCs lacking toll-like receptor 4, which is responsible for recognizing lipopolysaccharide. As a proof-of-concept demonstration, gene-based therapy mediated by BNMs enhances antigen cross-presentation in DCs and generates a remarkable antitumor effect.
Article
Endocrinology & Metabolism
Aoxing Cheng, Tian Xu, Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo, Haiyan Zhang, Xin Pan, Yucai Wang, Liu Liu, Kaiguang Zhang, Jue Shi, Xuebiao Yao, Jing Guo, Zhenye Yang
Summary: Research has found that redox metabolites in cancer cells fluctuate during the cell cycle, but the functional impacts of these metabolic oscillations are still unknown. A mitosis-specific upsurge of nicotinamide adenine dinucleotide phosphate (NADPH) has been discovered, which is essential for tumor progression. This upsurge is produced by glucose 6-phosphate dehydrogenase (G6PD) upon mitotic entry and neutralizes elevated reactive oxygen species (ROS), preventing ROS-induced inactivation of mitotic kinases and chromosome missegregation. The study reveals that aneuploid cancer cells with high ROS levels depend on a G6PD-mediated NADPH upsurge during mitosis to protect against ROS-induced chromosome missegregation, making this upsurge a cell cycle-dependent metabolic vulnerability.
Article
Nanoscience & Nanotechnology
Wenxiu Duan, Lifeng Hang, Yinchu Ma, Qin Wang, Xinfeng Tang, Wei Jiang, Yi Wu, Weifu Lv, Yucai Wang
Summary: Nano-metal-organic frameworks (nMOFs) can load and protect bioactive macromolecules, and selectively release them at the target location after stimulation, showing promising applications in co-delivery of biomacromolecules.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kaige Chen, Zheng Zhang, Ziyuan Fang, Jiachen Zhang, Qian Liu, Wang Dong, Yang Liu, Yucai Wang, Jun Wang
Summary: This study reports a nano-mediated strategy to stimulate the precise clearance of activated neutrophils using an artificial aged signal, thus alleviating inflammation. The findings show that this strategy effectively targets and clears activated neutrophils, preventing inflammatory responses and tissue damage.
Article
Chemistry, Multidisciplinary
Qian Liu, Li Wang, Yitan Su, Wang Dong, Huiru Wang, Yang Liu, Hang Liu, Lianxin Liu, Yucai Wang
Summary: Protein drugs are potential candidates for treating complex diseases like cancer. Metal-organic-framework (MOF) is considered a promising carrier for encapsulating protein drugs, but its limited loading efficiency and potential toxicity hinder its clinical application. In this study, a tumor targeted collagenase-encapsulating MOF (PMOCol) is developed for refining deep tissue pancreatic cancer photoimmunotherapy. PMOCol demonstrates high encapsulation efficiency (80.3 wt%) and can effectively regulate extracellular matrix, enhancing immunocyte infiltration for cancer immunotherapy. By integrating a hyperthermia agent, PMOCol induces acute immunogenicity and systemic immune memory to prevent tumor development and recurrence.
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Wuxuan Wang, Zheng Zhang, Yi Liu, Lingqi Kong, Wenyu Li, Wei Hu, Yucai Wang, Xinfeng Liu
Summary: In this study, we designed a nanomedicine system based on the neutrophil piggybacking strategy for treating cerebrovascular and neural injury caused by ischemia-reperfusion. The system demonstrated efficient blood-brain barrier penetration, reduced oxidative damage and apoptosis, inhibited ferroptosis, and achieved satisfactory neuroprotection.
BIOMATERIALS SCIENCE
(2022)
