Article
Materials Science, Multidisciplinary
Maria San Anselmo, Elena Lantero, Yunuen Avalos-Padilla, Ines Bouzon-Arnaiz, Miriam Ramirez, Alejandro Postigo, Jose Luis Serrano, Teresa Sierra, Silvia Hernandez-Ainsa, Xavier Fernandez-Busquets
Summary: The development of improved therapeutic compounds and targeted delivery strategies for antimalarial drugs is essential due to the increasing resistance of Plasmodium to existing medication. This study presents the use of dendronized hyperbranched polymers (DHPs) coated with heparin for specific targeting of Plasmodium-infected red blood cells. The resulting DHP-heparin complexes exhibit antimalarial activity and specific targeting capabilities.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Pei Huang, Changrong Wang, Hongzhang Deng, Yongfeng Zhou, Xiaoyuan Chen
Summary: The development of multifunctional nanoparticles with desired properties is important in the field of nanotechnology and is expected to revolutionize cancer diagnosis and treatment. Surface engineering of nanoparticles is crucial for their in vivo fate, bioavailability, and theranostic outcomes. Different surface functionalities have been utilized to enhance cancer therapy and imaging, including inorganic and organic materials, biomembranes, and targeting moieties. These surface modifications have the potential to be applied in various scenarios and contribute to the clinical translation of NP-based platforms for cancer theranostics.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Muzi Li, Wen Zhang, Jiaxin Li, Yinghe Qi, Chen Peng, Nan Wang, Huili Fan, Yan Li
Summary: Nanocarriers play a crucial role in drug delivery but face physiological barriers that limit their therapeutic efficiency. This review focuses on the application of zwitterionic polymers, which have emerged as a promising alternative to improve drug delivery by resisting nonspecific protein adsorption. It discusses the structures, characteristics, strategies, and potential development of zwitterionic polymers in overcoming physiological barriers.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas Schaefer, Andreas Pluckthun, Mark D. Distefano
Summary: A novel method for the conjugation of genetically modified proteins with fluorescent dyes or cell-killing agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chae Gyu Lee, Tae-Hyuk Kwon
Summary: Redox-responsive nanocarriers using disulfides or thiols have gained attention due to higher GSH levels in cancer cells. However, their selectivity between normal and cancer cells is still unclear. Nanocarriers exhibit different cytotoxicities in cancer cells under redox-active conditions, requiring consideration of GSH levels, ROS levels, and other cancer cell conditions for smart drug delivery systems. This article reviews the design of redox-responsive polymers and proposes a molecular design for controlling nanocarrier morphology based on GSH and ROS levels to enhance cytotoxicity difference between normal and cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Julie Mougin, Claudie Bourgaux, Patrick Couvreur
Summary: Self-assembled cylindrical aggregates made of amphiphilic molecules have unique physico-chemical properties that are valuable for industrial applications and potential therapeutic purposes, such as designing elongated drug nanocarriers. Current research focuses on exploring the main forces driving the unidirectional growth of nanodevices and aiming to minimize unnecessary side effects and potential toxicity by forming pure nanodrugs.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Environmental Sciences
Afshin Taheriazam, Maliheh Entezari, Zeinab Mohammadi Firouz, Shima Hajimazdarany, Mohammad Hossein Heydargoy, Amir Hossein Amin Moghadassi, Ali Moghadaci, Amin Sadrani, Motahhar Motahhary, Abdorrahman Harif Nashtifani, Amirhossein Zabolian, Teimour Tabari, Mehrdad Hashemi, Rasoul Raesi, Mengyuan Jiang, Xuebin Zhang, Shokooh Salimimoghadam, Yavuz Nuri Ertas, Dongdong Sun
Summary: Nature-derived polymers, such as chitosan, have features like biocompatibility, biodegradability, low toxicity, and ease of modification, making them promising materials for drug and gene delivery. Chitosan-based nanocarriers can provide site-specific delivery and have shown potential in clinical trials. They have also been extensively applied in diabetes mellitus therapy, especially in oral insulin delivery and wound healing.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Vladimir P. Zhdanov
Summary: The release of drugs or vaccine molecules from carriers is limited by diffusion and/or carrier dissolution and/or erosion. With decreasing carrier size, the release becomes kinetically limited. Nanocarriers often have structural heterogeneity, where molecule absorption is affected by energetic heterogeneity. A kinetic model is proposed, and the predicted kinetics can be fitted by Weibull or Korsmeyer-Peppas expressions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Firas Sukkar, Medhat Shafaa, Mohamed El-Nagdy, Wael Darwish
Summary: The study demonstrates that using two polymeric nanocarriers for co-delivery of sorafenib can effectively inhibit cancer cell proliferation and achieve anticancer effects through cell cycle arrest. Both PCL and PLGA models significantly reduced the viability of HepG2 cells and showed high levels of cell necrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Ranjit De, Manoj Kumar Mahata, Kyong-Tai Kim
Summary: This article comprehensively investigates the effects of structural design-based varieties of PNCs on drug delivery profiles, with perspectives highlighting the inevitability of incorporating both multi-stimuli-responsive and multi-drug delivery properties in a single carrier.
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Review
Biotechnology & Applied Microbiology
Ahmed Alalaiwe
Summary: Nanometals can enhance drug solubility and target specificity, while conjugation processes can improve treatment efficiency and targeting. Nanomedicine contributes to the development of personalized cancer therapy.
Article
Chemistry, Physical
Seyithan Kansiz, Yasar Murat Elcin
Summary: Liposomes and polymersomes are self-assembled vesicles that can encapsulate hydrophilic and hydrophobic therapeutics, making them important in drug delivery research. They have versatile designs for different drug delivery applications. This review article discusses the physical and biological barriers to efficient drug delivery and explores the design approaches, properties, targeting strategies, and stimuli response of liposomes and polymersomes. The challenges, recent clinical developments, and future perspectives are also addressed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Engineering, Biomedical
Bianka Golba, Edmondo M. Benetti, Bruno G. De Geest
Summary: Cyclic polymers, lacking chain ends, possess unique architecture and properties that make them suitable for various applications in nano-, micro-, and macro-scale materials. In the biomedical field, biomaterials based on cyclic polymers demonstrate distinct properties in terms of drug delivery efficiency and surface activity. Future challenges in utilizing cyclic polymers in biomedical applications are also discussed in this review.
Article
Polymer Science
Sedigheh Ehsanimehr, Peyman Najafi Moghadam, Wim Dehaen, Vahid Shafiei-Irannejad
Summary: In this study, nanocrystalline cellulose (NCC) was prepared and modified for drug delivery applications. Two pathways were followed to synthesize nanocarriers, one involving cyclodextrin (CD) and folic acid (FA) interaction, and the other directly grafting FA onto the modified cellulose. Drug loading capacity and release were characterized, and the effect of drug-loaded nanocarriers on breast cancer cells was investigated, showing some inhibitory effects in vitro.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Yan Song, Runqiu Zhu, Ziyu Liu, Xingyi Dai, Jie Kong
Summary: Phase-transformation HfO2 nanoparticles were added to PDC-SiBCN to improve its mechanical performance and electromagnetic wave absorption, allowing its application as a structural load component in an environment with electromagnetic interference.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Qingfu Ban, Yan Li, Luwei Li, Yusheng Qin, Yaochen Zheng, Huimin Liu, Jie Kong
Summary: Graphitic carbon materials often have poor impedance matching and unsatisfactory electromagnetic wave absorption. Engineered amorphous carbon is developed to produce hierarchical carbonaceous nanocomposites, aiming to enhance dielectric polarization and improve electromagnetic wave absorption. The hierarchical structure can be regulated to reduce polarization relaxation loss and conductive loss, and multiple reflections and scatterings contribute to increased absorption capability.
Article
Polymer Science
Shuofeng Liang, Shuxiu Li, Chenrui Yuan, Dachuan Zhang, Jiahui Chen, Si Wu
Summary: Researchers have developed a polymer with azobenzene that exhibits more efficient photoinduced reversible solid-to-liquid transitions compared to its analogue. The polymer undergoes reversible cis-trans photoisomerization, and the more flexible backbone allows for faster transition from solid to liquid state. This study provides a new strategy for designing rapidly healable polymers with efficient solid-to-liquid transitions.
Article
Chemistry, Multidisciplinary
Chengwei Liu, Ann-Kathrin Steppert, Yazhi Liu, Philipp Weis, Jianyu Hu, Chen Nie, Wen-Cong Xu, Alexander J. C. Kuehne, Si Wu
Summary: Researchers have developed a photo- and thermostable anti-counterfeiting material by using photopatterning and thermal annealing techniques on a photoresponsive conjugated polymer. The stability of the material is achieved through interchain stacking promoted by thermal annealing and the desirable thermal properties endowed by the conjugated structure. This study provides a new strategy for the development of highly stable and secure anti-counterfeiting materials.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Jin Liang, Zhiheng Wei, Xicheng Zhang, Fengbo Chen, Xin Cao, Zongcheng Li, Benzheng Gao, Xin Qi, Shaofeng Tang, Jie Kong
Summary: In this research, cementite/Fe nanoparticles anchored on nitrogen-doped carbon nanotubes (Fe3C/Fe/N-CNTs) composites were successfully synthesized through a one-step pyrolyzing procedure. The obtained magnetoelectric composites exhibited excellent microwave absorption properties, with a minimum reflection loss of -54.4 dB at 10.4 GHz, a matching thickness of 2.3 mm, and low filler loading (15%). The outstanding performance can be attributed to the CNT network, hollow CNT structure, magnetic Fe3C/Fe, and multiple interfaces of the composites.
Review
Chemistry, Multidisciplinary
Dachuan Zhang, Chenrui Yuan, Yang Zhou, Si Wu
Summary: Liquid-crystal polymers combine the order-disorder transition of liquid crystals and the superior properties of polymers. The phase transition from liquid-crystal phase to isotropic state allows for large, controllable, and reversible deformation of polymers, making liquid-crystal polymers valuable for shape-morphing materials. This review focuses on the recent development of shape-morphing liquid-crystal polymers, discussing energy conversion modes, material design strategies, and further applications. Novel material design methods and a wide range of applications of shape-morphing liquid-crystal polymers are discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Feifan Zheng, Chunwei Li, Zongcheng Li, Xin Cao, Hebin Luo, Jin Liang, Xiaodong Zhao, Jie Kong
Summary: Composite solid electrolytes are crucial for all-solid-state lithium batteries, which are considered the next-generation energy storage devices. Numerous studies have shown that fillers in composite solid electrolytes can improve ion transport behavior by optimizing the ion transport path. The performance is closely related to filler structure and its interaction with other electrolyte components. This review focuses on dimensional design of fillers, as well as ion transport mechanism and filler-electrolyte interaction in advanced composite solid electrolytes. Strategies for designing composite solid electrolytes with high room temperature ionic conductivity are summarized to assist research for high-performance composite solid electrolytes.
Article
Nanoscience & Nanotechnology
Yuzhang Du, Yichen Liu, Wenxuan Lu, Xuan Zhang, Aoao Wang, Jie Kong
Summary: This article introduces a new type of strain sensor that achieves ultrahigh sensitivity, high reliability, and excellent durability through bioinspired hierarchical structure and hydrogen bond-enhanced interfacial interactions. It can accurately diagnose and distinguish symptoms of chronic diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ruizhe Xing, Guoxuan Xu, Ning Qu, Rui Zhou, Jiayi Yang, Jie Kong
Summary: This work presents a gallium indium alloy-doped SiBOC ceramic with a liquid-metal-in-ceramic feature. By mixing EGaIn nanoparticles with a UV-curable ceramic precursor, a resin suitable for 3D-printing is obtained. The resulting SiBOC ceramics show improved mechanical strength and dielectric properties, achieving excellent electromagnetic wave absorption across multiple frequency bands.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Qiang Zhuang, Yanan Wang, Chengxuan Luo, Zhiheng Ma, Lingzi Shi, Jianxin Chen, Jianke Sun, Jie Kong
Summary: In this study, a high-performance nanostructured composite material for electromagnetic wave absorption was developed. The nano composites treated at 800°C exhibited excellent wave absorption performance and had a wide effective absorption bandwidth.
Article
Multidisciplinary Sciences
Yan Li, Fusheng Wang, Chenguang Huang, Jianting Ren, Donghong Wang, Jie Kong, Tao Liu, Laohu Long
Summary: In this paper, it is demonstrated that pulse current can effectively reduce delamination damage and residual deformation in 3D orthogonal woven composites, improving their mechanical properties and damage tolerance. A damage reduction strategy is proposed by combining structural and electromagnetic properties, and an experimental platform is developed to investigate the effects of pulse current and impact force on woven composites. Experimental results show that pulse current can effectively reduce delamination damage and residual deformation. A multi-field coupled damage model is developed to analyze the evolutions of temperature, current, and damage, providing insights into the mechanism of damage reduction and a potential approach for improving damage tolerance of these composites.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Dongyan Shao, Ting Bai, Bobo Zhu, Xiaojia Guo, Kai Dong, Junling Shi, Qingsheng Huang, Jie Kong
Summary: This study develops a polymeric micelle-based IL-15/IL-2 codelivery system (IL-15/2-PEG-PTMC) for natural killer (NK) cell activation. It noticeably delays the growth of tumors in mice compared to conventional NK cell activation approach, that is free IL-15 and IL-2. It is surprisingly found that cholesterol metabolism is highly involved in the NK cell activation by IL-15/2-PEG-PTMC.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Dong Yang, Guangming Tian, Jianhua Ma, Xinhai He, Jie Kong
Summary: Four triphenylamine (TPA)-substituted boron ketoimine molecules (TPA-BKI a-d) are designed and synthesized, which exhibit high emission efficiency in both solution and solid-state. The asymmetry of molecular and the planarity of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) sides in the excited state enable TPA-BKI a-d to have rigidified conformations, resulting in bright emission in dilute solution. The highly twisted structures of TPA-BKI a-d prevent close contact between molecules and detrimental exciton interactions, leading to efficient emission in the solid state. Additionally, the emission colors can be modulated by incorporating different substituents through the amino-yne click reaction. Moreover, TPA-BKI-d shows reversible alterations of optical properties in both solution and solid states due to the protonation and deprotonation of the amino substituents.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Polymer Science
Yun-Shuai Huang, Guofeng Xu, Si Wu
Summary: In this study, a photoresponsive liquid crystal polymer (LCP) was designed and synthesized by copolymerizing a styrylpyrene-containing monomer and a monomer containing mesogen 4-cyanophenyl benzoate. The successful synthesis of LCP was confirmed by gel permeation chromatography and H-1 nuclear magnetic resonance. The LCP showed high thermal stability and thermal annealing promoted its orientation. The dimerization of the styrylpyrene units in LCP could control the crosslinking densities, regulating the network structures and properties. These properties make LCP a promising photoresponsive material.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Materials Science, Biomaterials
Xiaoli Li, Song Guo, Weixing Deng, Si Wu, Pengfei Sun, Yuanli Liu
Summary: A novel water-soluble squaric acid nanoparticle (SQ-POEGMA) was synthesized in this study, which exhibited low toxicity and excellent photostability. The nanoparticle was constructed by attaching a water-soluble oligomer (POEGMA) to the small molecule squaric acid through a click chemistry reaction. The SQ-POEGMA showed a high photothermal conversion efficiency and effectively inhibited cancer cell growth with a 94% tumor inhibition rate under 808 nm laser irradiation, without causing noticeable side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
