Direct and Enantioselective Synthesis of N−H-Free 1,5-Benzodiazepin-2-ones by an N-Heterocyclic Carbene Catalyzed [3+4] Annulation Reaction

Stereoselective Synthesis of Functionalized Tetrahydro-1H-1,2-diazepines by N-Heterocyclic Carbene-Catalyzed [3 + 4] Annulation

(2017) Shi-Ya Zhu et al.   ORGANIC LETTERS

Formal [3 + 4] Annulation of α,β-Unsaturated Acyl Azoliums: Access to Enantioenriched N–H-Free 1,5-Benzothiazepines

(2017) Chao Fang et al.   ORGANIC LETTERS

Synthesis of Dihydropyridinone-Fused Indoles and α-Carbolines via N-Heterocyclic Carbene-Catalyzed [3 + 3] Annulation of Indolin-2-imines and Bromoenals

(2017) Liang Yi et al.   ORGANIC LETTERS

Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives

(2017) Nobuhiro Obara et al.   SYNLETT

N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium

(2017) Changhe Zhang et al.   ACS Catalysis

Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions

(2016) Xingxing Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

(2016) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Catalysis and Activation with N-Heterocyclic Carbenes

(2016) Michael H. Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to Spiro and Fused Indole Derivatives from α,β-Unsaturated Aldehydes Enabled by N-Heterocyclic Carbene Catalysis

(2016) Weifang Tang et al.   CHEMICAL RECORD

N-Heterocyclic Carbene-Catalyzed [3 + 4] Annulation of Enals and Alkenyl Thiazolones: Enantioselective Synthesis of Thiazole-Fused ε-Lactones

(2016) Zhi-Qin Liang et al.   JOURNAL OF ORGANIC CHEMISTRY

Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

(2016) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin-3-ones with a Tetrasubstituted Carbon Stereocenter

(2015) Junyu Xu et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

(2015) Rajeev S. Menon et al.   CHEMICAL SOCIETY REVIEWS

(Z)-Stereoselective Synthesis of Mono- and Bis-heterocyclic Benzimidazol-2-ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction

(2015) Zhigang Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams

(2015) Delu Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones

(2015) Chun-Lin Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First synthesis of BU-4664L

(2015) Yusuke Takahashi et al.   TETRAHEDRON LETTERS

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking

(2014) Hongtao Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Heterocyclic carbene-catalyzed enantioselective synthesis of functionalized cyclopentenes via α,β-unsaturated acyl azoliums

(2014) Santigopal Mondal et al.   CHEMICAL COMMUNICATIONS

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

(2014) Min Wang et al.   CHEMICAL COMMUNICATIONS

Bifunctional N-Heterocyclic Carbene Catalyzed [3+4] Annulation of Enals and Aurones

(2014) Zhi-Qin Liang et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Indolin-3-ones with Bromoenals

(2014) Qijian Ni et al.   Chemistry-An Asian Journal

N-Heterocyclic Carbene Catalysis as a Tool for Gaining Access to the 3,4-Dihydropyran-2-one Skeleton

(2014) Domenico C. M. Albanese et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized Coumarins and Quinolinones by NHC-Catalyzed Annulation of Modified Enals with Heterocyclic C–H Acids

(2014) Santhivardhana Reddy Yetra et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene Catalyzed Switchable Reactions of Enals with Azoalkenes: Formal [4 + 3] and [4 + 1] Annulations for the Synthesis of 1,2-Diazepines and Pyrazoles

(2014) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed [3+4] Cycloaddition and Kinetic Resolution of Azomethine Imines

(2014) Ming Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative N-heterocyclic carbene (NHC)–Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

(2014) Yu Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Odorless, One-Pot Synthesis of Thioesters from Organic Halides, Thiourea and Benzoyl Chlorides in Water

(2013) Guo-ping Lu et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective N-Heterocyclic Carbene-Catalyzed Annulations of 2-Bromoenals with 1,3-Dicarbonyl Compounds and EnaminesviaChiral α,β-Unsaturated Acylazoliums

(2013) Santhivardhana Reddy Yetra et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed [4+3] Annulation of Enals ando-Quinone Methides: Highly Enantioselective Synthesis of Benzo-ε-Lactones

(2013) Hui Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations

(2013) Javier Izquierdo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis and Anticancer Activity Evaluation of Diazepinomicin Derivatives

(2013) Yongguo Yu et al.   Letters in Drug Design & Discovery

N-heterocyclic carbene-catalyzed reactions of C–C unsaturated bonds

(2013) Xiang-Yu Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes

(2013) Santhivardhana Reddy Yetra et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Stereoselective Cascade Reaction: Synthesis of Functionalized Tetrahydroquinolines

(2013) Hai-Rui Zhang et al.   ORGANIC LETTERS

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene Catalyzed Reactions of α-Bromo-α,β-unsaturated Aldehydes/α,β-Dibromoaldehydes with 1,3-Dinucleophilic Reagents

(2012) Changsheng Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles

(2012) Ding Du et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Bromoenal and 1,3-Dicarbonyl Compounds

(2011) Fang-Gang Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation

(2011) Xing Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

First Highly Enantioselective Synthesis of Benzodiazepinones by Catalytic Hydrogenation

(2010) Magnus Rueping et al.   ADVANCED SYNTHESIS & CATALYSIS

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

(2009) Satoshi Miyanaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Features and applications of reactions of α,β-unsaturated N-acylbenzotriazoles with amino compounds

(2008) Xiaoxia Wang et al.   TETRAHEDRON