Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 65, Pages 9007-9010Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04411b
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Funding
- Howard Hughes Medical Institute
- David and Lucile Packard Fellowship for Science and Engineering
- Deutsche Forschungsgemeinschaft (DFG Research Fellowship) [309199717]
- Chemistry-Biology Interface Training Program [GM070421]
- National Institutes of Health [S10 RR027109]
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Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate which residues are important for substrate recognition, proteolysis, and lasso peptide macrocyclization.
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