Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 38, Pages 4774-4777Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc01764f
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Funding
- National Natural Science Foundation of China [31770055, 31570031, 31772242]
- Ministry of Science and Technology of China [2013CB734000]
- Youth Innovation Promotion Association of CAS [2016087]
- International Partnership Program of Chinese Academy of Science [153211KYSB20170014]
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Here, we demonstrate an easy-to-implement and general bio-sensing strategy by coupling the small-molecule recognition of the bacterial allosteric transcription factor (aTF) with isothermal strand displacement amplification (SDA) in vitro. Based on this strategy, we developed two biosensors for the detection of an antiseptic, p-hydroxybenzoic acid, and a disease marker, uric acid, using bacterial aTF HosA and HucR, respectively, highlighting the great potential of this strategy for the development of small-molecule biosensors.
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