Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 23, Pages 2862-2865Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00856f
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Funding
- Ministerio de Economia, Industria y Competitividad
- FEDER (European Union) [CTQ2017-84900-P]
- Spanish Government [RyC-2016-20187]
- Fondo Social Europeo [APOST/2016/139]
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A multicatalytic approach that combines a bifunctional Bronsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
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