4.7 Article

Rhodium-catalyzed asymmetric hydrogenation of beta-branched enamides for the synthesis of beta-stereogenic amines

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 47, Pages 6024-6027

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc02798f

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Funding

  1. National Natural Science Foundation of China [21572131, 21620102003]
  2. Shanghai Municipal Education Commission [201701070002E00030]
  3. Science and Technology Commission of Shanghai Municipality [15JC1402200]

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Using a rhodiumcomplex of a bisphosphine ligand (R)-SDP, beta-branched simple enamides with a (Z)-configuration were hydrogenated to beta-stereogenic amines in quantitative yields and with excellent enantioselectivities (88-96% ee).

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