Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 43, Pages 5426-5429Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03097a
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Funding
- Deutsche Forschungsgemeinschaft, DFG [SFB-1035]
- Institute for Advanced Study (IAS) - German Excellence Initiative
- European Union Seventh Framework Program [291763]
- IAS Hans Fischer Senior Fellowship
- DAAD PhD scholarship
- NIH [AG048934]
- MEYS of the Czech Republic under the project CEITEC [LQ1601]
- Technische Universitaet Muenchen
- NATIONAL INSTITUTE ON AGING [R01AG048934] Funding Source: NIH RePORTER
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In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
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