Article
Biochemistry & Molecular Biology
Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Summary: The study focuses on delivering bioactive agents through specific targeting of fructose-specific transporter GLUT5, providing a potential for developing cancer-specific imaging and drugs. The results show a significant relationship between the size and hydrophobicity of drug conjugates and cancer cell selectivity, indicating the importance of maintaining appropriate hydrophilicity for GLUT-mediated delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Rabi Sankar Das, Ayan Mukherjee, Samiran Kar, Tapas Bera, Shreya Das, Arunima Sengupta, Samit Guha
Summary: This article describes a novel red fluorescent mechanically interlocked molecule with dual targeting functionality for live cancer cell specific active targeting and imaging of malignant lysosomes.
Article
Biochemistry & Molecular Biology
Adelina Oronova, Marina Tanasova
Summary: The targeting of GLUTs has been used in the development of diagnostic and therapeutic tools. Alterations in cellular metabolic processes associated with metabolic disorders and diseases have led to interest in this area. GLUT5, which has associations with metabolic diseases including cancer, is a promising target for developing specific tools. In this study, a non-radiolabeled glycoconjugate was developed as a potential PET imaging probe that targets GLUT5, and its effectiveness was demonstrated in a breast cell line using fluorescence detection techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ilya Likhotkin, Richard Lincoln, Mariano L. Bossi, Alexey N. Butkevich, Stefan W. Hell
Summary: We designed caging-group-free photoactivatable live-cell permeant dyes with red fluorescence emission and similar to 100 nm Stokes shifts based on a 1-vinyl-10-silaxanthone imine core structure. These fluorophores can undergo byproduct-free one-and two-photon activation and are compatible with various fluorescence microscopy techniques. They have been successfully used for strain-promoted tetrazine ligation, self-labeling protein tags, and multiplexing imaging applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoke Huang, Jing Fang, Weiqi Lai, Yu Hu, Liang Li, Yuanyou Zhong, Shiwei Yang, Dan He, Rui Liu, Qingfeng Tang
Summary: This study demonstrates that treatment with IL-6 activates fructose uptake and fructolysis in oral squamous cell carcinoma (OSCC) cells and prostate cancer cells. Mechanistically, the transcription factor STAT3 associates with the Glut5 promoter region and enhances Glut5 transcription in response to IL-6 treatment. Knockdown of Glut5 attenuates IL-6-induced tumor cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chunlin Zhang, Jianping Hu, Yingying Jiang, Shuo Tan, Kunpeng Zhu, Chao Xue, Yunlu Dai, Feng Chen
Summary: This study demonstrates a novel biomineralization-inspired strategy for the synthesis of a fructose incorporated manganese phosphate (Fru-MnP) nanoplatform for targeted therapy, drug-free therapy, and MRI imaging of osteosarcoma. The Fru-MnP nanoplatform produces reactive oxygen species (ROS) through the Mn2+-driven Fenton reaction within osteosarcoma cells, leading to caspase-mediated apoptosis and efficient cancer cell killing. Additionally, it serves as an effective tumor-specific MRI contrast agent, allowing for MRI-monitored chemodynamic therapy.
Review
Biochemistry & Molecular Biology
Aqian Song, Yuanpeng Mao, Hongshan Wei
Summary: GLUT5, a membrane transporter responsible for fructose transportation, plays a key role in the impact of high fructose diet on health and cancer development. However, the lack of complete understanding of its molecular structure and mechanism poses challenges in studying the relationship between GLUT5 and cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Chemistry, Multidisciplinary
Shuxin Wei, Zhao Li, Wei Lu, Hao Liu, Jiawei Zhang, Tao Chen, Ben Zhong Tang
Summary: Multicolor fluorescent polymeric hydrogels (MFPHs) are three-dimensionally crosslinked hydrophilic polymer networks with tunable emission color, tissue-like mechanical properties, and fabulous biocompatibility, holding great potential in sensing, bioimaging, and soft robotics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Zaklos-Szyda, Nina Pietrzyk, Agnieszka Kowalska-Baron, Adriana Nowak, Katarzyna Chalaskiewicz, Marcin Ratajewski, Grazyna Budryn, Maria Koziolkiewicz
Summary: The chronic consumption of large amounts of fructose in food has been linked to hypertension and disturbances in carbohydrate and lipid metabolism, leading to obesity, non-alcoholic fatty liver disease, insulin resistance, and type 2 diabetes. The absorption of fructose by small intestine cells and hepatocytes is mediated by proteins such as GLUT5. Extracts from plants like B. juncea and M. chamomilla have been shown to reduce fructose uptake and downregulate GLUT5 expression, potentially through the inhibition of transcription factors TXNIP and ChREBP.
Article
Chemistry, Multidisciplinary
Xue Tian, Lloyd C. Murfin, Luling Wu, Simon E. Lewis, Tony D. James
Summary: Small-molecule based fluorescent probes play an increasingly important role in detecting and imaging biological signaling molecules due to their simplicity, high selectivity, and real-time analysis capabilities. Various sensing mechanisms, including FRET, ICT, PeT, ESIPT, AIE, as well as dual/triple sensing mechanisms, are highlighted, but challenges remain. Future development should focus on improving small-molecule fluorescent probes for biosensing applications.
Article
Biochemistry & Molecular Biology
Jan Matthias Peschel, Lien Sabrina Reichel, Tim Hoffmann, Christoph Enzensperger, Ulrich Sigmar Schubert, Anja Traeger, Michael Gottschaldt
Summary: This article introduces a modified branched poly(ethylene imine) (bPEI) that is enhanced with d-fructose to improve biocompatibility and target breast cancer cells through the overexpressed GLUT5 transporter. Several fructose-substituted bPEI polymers with varying molecular weights, degrees of substitution, and linker positions are synthesized and characterized. In vitro experiments show reduced cytotoxicity, specific uptake of siRNA polyplexes, and targeted knockdown of GFP in triple-negative breast cancer cells (MDA-MB-231) compared to noncancer cells (HEK293T) after fructose functionalization of 10 kDa bPEI.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Geriatrics & Gerontology
Abhisek Mukherjee, Rabab Al-Lahham, Mark E. Corkins, Sourav Samanta, Ann M. Schmeichel, Wolfgang Singer, Phillip A. Low, Thimmaiah Govindaraju, Claudio Soto
Summary: This study identified fluorescent dyes that specifically probe Aβ aggregates, enabling visualization in different colors and potential diagnostic applications for Alzheimer's disease (AD). The dyes also have the potential for small animal imaging of Aβ pathology and can contribute to understanding the relation between Aβ deposits and clinical diversity in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Srijani Basu, Catherine Liu, Xi Kathy Zhou, Ryohei Nishiguchi, Taehoon Ha, Justin Chen, Melanie Johncilla, Rhonda K. Yantiss, David C. Montrose, Andrew J. Dannenberg
Summary: This study provides the first evidence that reduced levels of GLUT5, the fructose transporter, worsen experimental colitis upon fructose feeding, an effect mediated by changes in the gut microbiota. Moreover, GLUT5 expression is reduced in Crohn's ileitis. Overall, these findings demonstrate the importance of interactions between dietary fructose and host GLUT5 as determinants of both the composition of colonic microbiota and severity of experimental colitis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alison G. Tebo, Benjamien Moeyaert, Marion Thauvin, Irene Carlon-Andres, Dorothea Boken, Michel Volovitch, Sergi Padilla-Parra, Peter Dedecker, Sophie Vriz, Arnaud Gautier
Summary: Spectrally separated fluorophores enable the observation of multiple targets in living cells simultaneously for a deeper understanding of cell functions. Engineered fluorogen-activating tags based on the FAST system offer orthogonality in recognition and spectral properties, allowing efficient multicolor imaging of proteins in live cells.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Irina Taneva, Dorothee Grumann, Dietmar Schmidt, Elina Taneva, Ulrike von Arnim, Thomas Ansorge, Thomas Wex
Summary: This study investigated the contribution of gene variants to acquired fructose malabsorption and found that gene variants in the coding exons, adjacent intronic regions, and proximal promoter region of the SLC2A5 gene are unlikely to be associated with the genetic predisposition to this condition.
BMC GASTROENTEROLOGY
(2022)
Article
Chemistry, Organic
Shahien Shahsavari, Dhananjani N. A. M. Eriyagama, Bhaskar Halami, Vagarshak Begoyan, Marina Tanasova, Jinsen Chen, Shiyue Fang
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Zhijie Chen, Zeynabou Thiam, Aleksander Shkurenko, Lukasz J. Weselinski, Karim Adil, Hao Jiang, Dalal Alezi, Ayalew H. Assen, Michael O'Keeffe, Mohamed Eddaoudi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Summary: The study focuses on delivering bioactive agents through specific targeting of fructose-specific transporter GLUT5, providing a potential for developing cancer-specific imaging and drugs. The results show a significant relationship between the size and hydrophobicity of drug conjugates and cancer cell selectivity, indicating the importance of maintaining appropriate hydrophilicity for GLUT-mediated delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Abdelrahman Ismail, Marina Tanasova
Summary: GLUTs are the primary method of sugar uptake in cells, but they may also play additional metabolic roles. Understanding these roles can lead to advancements in disease treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, Smitha Rao
Summary: Arsenic is a highly toxic environmental pollutant that has harmful effects on human health. In order to study its impacts, researchers have attempted to develop in-vitro cell culture models as animal models are costly and time-consuming. However, most studies have not accurately represented realistic environmental exposure conditions. This study exposed human skin cells to water-soluble arsenic extracted from contaminated soil to investigate its effects on cell viability, migration, and protein expression. The results showed that arsenic had a greater impact on HaCaT cells compared to HDFa cells. This methodical approach provides a way to study the effects of toxic elements under realistic environmental conditions and can be adapted for different exposure pathways.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Materials Science, Multidisciplinary
R. A. Makin, S. N. Hanumantharao, S. Rao, S. M. Durbin
Summary: Quantifying the disorder in polymer fibers provides a means to engineer specific material properties, such as electrical conductivity and mechanical strength. The amount of disorder is directly related to the material's Young's modulus, band gap, and specific capacitance.
Article
Biochemistry & Molecular Biology
Adelina Oronova, Marina Tanasova
Summary: The targeting of GLUTs has been used in the development of diagnostic and therapeutic tools. Alterations in cellular metabolic processes associated with metabolic disorders and diseases have led to interest in this area. GLUT5, which has associations with metabolic diseases including cancer, is a promising target for developing specific tools. In this study, a non-radiolabeled glycoconjugate was developed as a potential PET imaging probe that targets GLUT5, and its effectiveness was demonstrated in a breast cell line using fluorescence detection techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nazar Gora, Lukasz J. Weselinski, Vagarshak V. Begoyan, Andrew Cooper, Jun-yong Choe, Marina Tanasova
Summary: This study aimed to identify substrate-GLUT interactions that would differentiate major fructose transporters. By using conformationally locked fluorescently labeled mimetics as probes, the uptake distribution of fructose conformers and epimers was examined. The results demonstrated the discriminatory ability of fructose transporters and provided new tools for monitoring alterations in GLUT activities.
ACS CHEMICAL BIOLOGY
(2023)
Review
Materials Science, Multidisciplinary
James Dolgin, Samerender Nagam Hanumantharao, Stephen Farias, Carl G. Simon Jr, Smitha Rao
Summary: Electrospinning is a versatile technique to produce customizable nanofiber mats with various properties. It can be used with different types of polymers and post-processing methods to enhance the chemical and physical properties of the mats. The ability to influence cell behavior makes electrospinning a promising tool for tissue engineering and regenerative medicine. This review focuses on the mechanical and physical characteristics of nanofiber scaffolds and their impact on cell behavior.
Article
Nanoscience & Nanotechnology
Dilka Liyana Arachchige, Sushil K. Dwivedi, Sophia Jaeger, Adenike Mary Olowolagba, Mohamed Mahmoud, Daniel R. Tucker, Delaney Raine Fritz, Thomas Werner, Marina Tanasova, Rudy L. Luck, Haiying Liu
Summary: We have developed two highly sensitive cyanine dyes, probes A and B, for quick and sensitive sensing of NAD(P)H. These dyes showed low fluorescence and absorption peaks in the absence of NAD(P)H, but upon reduction of the probes, they exhibited well-defined donor-π-acceptor cyanine dyes. Probe A was successfully used to monitor NAD(P)H levels in live cells during glycolysis, under hypoxic conditions induced by CoCl2 treatment, and after treatment with cancer drugs. It was also employed to visualize NAD(P)H in Drosophila melanogaster first-instar larvae.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Shulin Wan, Tara Vohs, Tessa E. Steenwinkel, Walter Reynolds White, Adrian Lara-Ramirez, Rudy L. Luck, Thomas Werner, Marina Tanasova, Haiying Liu
Summary: Three near-infrared fluorescent probes A, B, and C have been developed to identify hypoxia via nitroreductase determinations. Theoretical calculations suggest the probes are not planar, and photon absorptions result in electron density transitions.
ACS APPLIED BIO MATERIALS
(2022)
Review
Materials Science, Biomaterials
Shounak Roy, Sanchita Sarkhel, Deepali Bisht, Samerender Nagam Hanumantharao, Smitha Rao, Amit Jaiswal
Summary: Overcoming antibiotic resistance is a major challenge for scientists, and the development of next-generation antimicrobials is crucial in addressing emerging infectious diseases. Biomaterials have shown broad-spectrum biocidal activity against bacteria and viruses through various modes of interaction. This review provides a comprehensive overview of the diverse interactions between biomaterials and microorganisms, and explores how different biomaterials can modulate antimicrobial mechanisms for effective therapeutic outcomes without resistance development.
BIOMATERIALS SCIENCE
(2022)
Article
Engineering, Biomedical
Samerender N. Hanumantharao, Carolynn A. Que, Brennan J. Vogl, Smitha Rao
IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY
(2020)
Meeting Abstract
Oncology
Carolynn Que, Samerender Nagam Hanumantharao, Brennan Vogl, Marina Tanasova, Smitha Rao
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
