A one-pot process for the enantioselective synthesis of tetrahydroquinolines and tetrahydroisoquinolines via asymmetric reductive amination (ARA)

Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2

(2018) Xuefeng Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Brønsted-Acid-Promoted Rh-Catalyzed Asymmetric Hydrogenation of N-Unprotected Indoles: A Cocatalysis of Transition Metal and Anion Binding

(2018) Jialin Wen et al.   ORGANIC LETTERS

Direct Asymmetric Ruthenium-Catalyzed Reductive Amination of Alkyl–Aryl Ketones with Ammonia and Hydrogen

(2017) Joan Gallardo-Donaire et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination

(2017) Ying Zhang et al.   ORGANIC LETTERS

Mechanism-Guided Development of a Highly Active Bis-thiourea Catalyst for Anion-Abstraction Catalysis

(2016) C. Rose Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strong Brønsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh–thiourea chiral phosphine complex via anion binding

(2016) Jialin Wen et al.   Chemical Science

Anion-Abstraction Catalysis: The Cooperative Mechanism of α-Chloroether Activation by Dual Hydrogen-Bond Donors

(2016) David D. Ford et al.   ACS Catalysis

Chiral phosphoric acid catalyzed oxidative kinetic resolution of cyclic secondary amine derivatives including tetrahydroquinolines by hydrogen transfer to imines

(2015) Kodai Saito et al.   CHEMICAL COMMUNICATIONS

Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea

(2014) Qingyang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 1,1-Disubstituted Tetrahydroisoquinolines by Lithiation and Substitution, with in Situ IR Spectroscopy and Configurational Stability Studies

(2014) Xiabing Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines: Access to Valuable Chiral 1-Aryl-Tetrahydroisoquinoline Scaffolds

(2013) Zi Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed by Chiral Iridium Complexes: Direct Synthesis for Optically Active 1,2,3,4-Tetrahydroisoquinolines

(2013) Atsuhiro Iimuro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodination of Remote Ortho-C–H Bonds of Arenes via Directed SEAr: A Streamlined Synthesis of Tetrahydroquinolines

(2013) William A. Nack et al.   ORGANIC LETTERS

Direct Catalytic Asymmetric Reductive Amination of Simple Aromatic Ketones

(2013) Mingxin Chang et al.   ORGANIC LETTERS

A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of β,β-Disubstituted Nitroalkenes

(2013) Qingyang Zhao et al.   ORGANIC LETTERS

Asymmetric Ion-Pairing Catalysis

(2012) Katrien Brak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Counteranion-Directed Catalysis: Concept, Definition, and Applications

(2012) Manuel Mahlau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The progression of chiral anions from concepts to applications in asymmetric catalysis

(2012) Robert J. Phipps et al.   Nature Chemistry

Enantioselective Synthesis of 1-Aryl-tetrahydroisoquinolines through Iridium Catalyzed Asymmetric Hydrogenation

(2012) Farouk Berhal et al.   ORGANIC LETTERS

Asymmetric Hydrogenation of Cyclic Imines Catalyzed by Chiral Spiro Iridium Phosphoramidite Complexes for Enantioselective Synthesis of Tetrahydroisoquinolines

(2012) Jian-Hua Xie et al.   ACS Catalysis

A Highly Efficient and Enantioselective Access to Tetrahydroisoquinoline Alkaloids: Asymmetric Hydrogenation with an Iridium Catalyst

(2011) Mingxin Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in the Chemistry of Tetrahydroquinolines

(2011) Vellaisamy Sridharan et al.   CHEMICAL REVIEWS

Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity

(2011) Tianli Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Effective Asymmetric Hydrogenation of CyclicN-Alkyl Imines with Chiral Cationic Ru-MsDPEN Catalysts‡

(2011) Fei Chen et al.   ORGANIC LETTERS

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

(2010) Jian-Hua Xie et al.   CHEMICAL REVIEWS

pH-Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water

(2009) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

(2009) Thomas A. Rano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metal−Brønsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

(2009) Chaoqun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Development of Double Axially Chiral Phosphoric Acids and Their Catalytic Transfer Hydrogenation of Quinolines

(2008) Qun-Sheng Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogenation of Quinolines Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid

(2008) Haifeng Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Air-Stable and Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of Quinoline Derivatives†

(2008) Zhi-Wei Li et al.   ORGANIC LETTERS

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

(2008) Laura Rubio-Pérez et al.   ORGANIC LETTERS