Article
Materials Science, Ceramics
Yao Hu, Song Bai, Xiaozan Wu, Songwen Tan, Yongju He
Summary: Understanding and controlling the biodegradability of mesoporous silica nanoparticles (MSN) is crucial for enhancing their bioapplications. Research has shown that physicochemical properties such as specific surface area, morphology, and pore size play a role in MSN biodegradation. Strategies including doping with metal ions and organic species have been introduced to improve the biodegradability of MSN.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Gyeongseok Yang, Sangpil Kim, Jun Yong Oh, Dohyun Kim, Seongeon Jin, Eunshil Choi, Ja-Hyoung Ryu
Summary: In this paper, a strategy for targeted delivery and controlled drug release using disulfide-incorporated mesoporous organosilica nanoparticles (MONs) was presented. The MONs were loaded with the chemodrug doxorubicin (DOX) and conjugated with a cell-specific affibody (Afb) fused with glutathione-S-transferase (GST). The particles exhibited prompt responsivity to the SS bond-dissociating glutathione (GSH), resulting in significant degradation of the particles and release of DOX, thereby enhancing cancer-therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Wei Wang, Fengmin Zhong, Dun Wang, Yuqi Zhao, Dongdong Peng, Shuang Li, Qian Ning, Shengsong Tang, Cui-Yun Yu, Hua Wei
Summary: The construction of dual gatekeepers-functionalized mesoporous organic silica nanoparticles with both physical and chemical mechanisms provides a solution for the extracellular stability and intracellular therapeutic efficiency. This study demonstrates the successful use of diselenium-bridged MONs decorated with a dual gatekeeper, azobenzene/polydopamine, for modulated drug delivery properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Steffi Tiburcius, Kannan Krishnan, Linta Jose, Vaishwik Patel, Arnab Ghosh, C. Sathish, Judith Weidenhofer, Jae-Hun Yang, Nicole M. Verrills, Ajay Karakoti, Ajayan Vinu
Summary: This study reports a direct single-step synthesis of mesoporous silica-based nanoparticles (MSNs) with a unique egg-yolk core-shell morphology. The nanoparticles have excellent textural properties and surface functionalization, making them an effective drug delivery system. The morphology and structure of the nanoparticles can be tuned by changing the pH of the synthesis medium.
Review
Chemistry, Physical
Sara Hooshmand, Sahar Mollazadeh, Negar Akrami, Mehrnoosh Ghanad, Ahmed El-Fiqi, Francesco Baino, Simin Nazarnezhad, Saeid Kargozar
Summary: Both MSNs and MBGs show promise in managing skin wounds, with the ability to treat acute, chronic, and malignant wounds. Their main advantages lie in strong biocompatibility and the capability to load and release a wide range of bioactive molecules and chemicals.
Article
Chemistry, Multidisciplinary
Ju Hyang Park, Kyung Eun Sung, Ki Hak Kim, Jong Ryeol Kim, Jongbok Kim, Geon Dae Moon, Dong Choon Hyun
Summary: This work presents the fabrication of AuNR@MSNs with independent sensitivities to pH and NIR light for reversible drug release. The inclusion of thermosensitive and pH-sensitive gatekeepers allows controlled drug release under specific conditions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Review
Chemistry, Physical
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh, Azam Marjani
Summary: In recent decades, significant progress has been made in cancer treatment, but finding more effective therapies is crucial. The application of drug delivery nanovehicles, particularly mesoporous silica nanoparticles (MSNPs), shows promise in reducing side effects. MSNPs possess excellent characteristics that make them suitable for targeted and stimuli responsive drug delivery in cancer treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Pharmacology & Pharmacy
Ruma Rani, Parth Malik, Sunena Dhania, Tapan Kumar Mukherjee
Summary: Breast cancer ranks second in cancer-related global female deaths. Late diagnosis and drug resistance limit the effectiveness of chemotherapeutic drugs, leading to relapse and metastasis. Core-shell mesoporous silica nanoparticles (MSNPs) have emerged as potential drug carriers for breast cancer treatment due to their high surface area, drug loading capacity, and stealth drug delivery capabilities. This article discusses the preparation methods, drug delivery mechanisms, and emerging utility of MSNPs in breast cancer treatment.
Article
Biochemistry & Molecular Biology
Cristina Carucci, Nicola Scalas, Andrea Porcheddu, Marco Piludu, Maura Monduzzi, Andrea Salis
Summary: Mesoporous silica nanoparticles (MSN) functionalized with triethylenetetramine (MSN-TETA) showed higher adsorption capacity and slower release rate for the antimicrobial drug sulphamethizole (SMZ), indicating the importance of intermolecular interactions in drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Riyasudheen Nechikkattu, Jungwon Kong, Young-Shin Lee, Hyun-Jung Moon, Jae-Ho Bae, Sun-Hee Kim, Sung Soo Park, Chang-Sik Ha
Summary: Tunable multi-responsive mesoporous silica nanoparticles were prepared through post-condensation/surface modification of MCM-41 nanoparticles. These nanoparticles exhibited excellent drug-loading capacity and dual responsive behavior, showing potential for cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Ceramics
Mehdi Talaei, S. A. Hassanzadeh-Tabrizi, Ali Saffar-Teluri
Summary: Magnetic CuFe2O4 nanoparticles were synthesized via a sol-gel combustion and coated with mesoporous SiO2. The CuFe2O4@SiO2 nanocomposite showed high ibuprofen loading and controlled drug release, with potential applications in biomedicine. Coating CuFe2O4 nanoparticles with mesoporous silica reduced cytotoxicity and improved drug release properties, although it decreased hyperthermia ability.
CERAMICS INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Environmental
Shuaipeng Feng, Junya Lu, Kaili Wang, Donghua Di, Zhenning Shi, Qinfu Zhao, Siling Wang
Summary: Mesoporous carbon nanoparticles and their derivatives have been extensively studied in photothermal therapy for cancer treatment due to their unique structure and excellent photothermal conversion efficiency. The current research focuses on the application of these nanoparticles in multimodal therapies and the development of low-power efficient photothermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Ying Li, Guoxing Deng, Xianlong Hu, Chenyang Li, Xiaodong Wang, Qinchang Zhu, Kai Zheng, Wei Xiong, Haiqiang Wu
Summary: Mesoporous silica nanoparticles (MSNs) have been extensively studied and applied in targeted drug-delivery systems for tumor therapy. They possess outstanding features, such as high surface area, large pore volume, tunable pore size, easy surface modification, and stable framework. This review covers the advances, challenges, and prospects of MSN-based targeted drug-delivery systems for anticancer treatment, providing new insights for researchers in this field.
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)