Reconfigurable DNA Nanoswitches for Graphical Readout of Molecular Signals

This study reports a DNA nanoswitch that can be used for visual display of outputs resulting from hybridization events of specific molecular inputs. Conformational changes of the DNA nanoswitch triggered by input DNA strands yield different pixels that collectively produce a graphical output on an agarose gel. This system has potential in molecular computation and biosensing approaches in which individual binding results can be translated into macromolecular visual readouts.