Article
Materials Science, Ceramics
Weibin Zhong, Lin Sun, Tao Yu, Changren Zhou
Summary: In this study, we successfully prepared calcium phosphate cement (CPC) with anti-washout and tissue adhesion properties by adding oxidized sodium alginate (OSA), which significantly enhanced tissue adhesion. The synergistic effect of OSA and citric acid in CPC resulted in the formation of a three-dimensional gel network structure, promoting adhesion between the cement and bone tissue. Our work aims to advance the development of injectable bone materials for clinical applications.
CERAMICS INTERNATIONAL
(2021)
Article
Biophysics
Hongyun Zhao, Junjia Kang, Xiaojie Lian, Yaping Song, Di Wang, Ruoyao Xu, Liqin Zhao, Di Huang, Baolong Niu
Summary: In this study, a gel network of SA-CA was introduced into the alpha-TCP/alpha-CSH composite to improve the cohesion property of bone cement. The results showed that the addition of SA-CA played an important role in enhancing the compressive strength and collapse resistance of the cement. Furthermore, the composite cement showed good compatibility with MC3T3 cells and promoted the differentiation of osteoblasts.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Ling Yu, Tian Gao, Wei Li, Jian Yang, Yinchu Liu, Yanan Zhao, Ping He, Xuefeng Li, Weichun Guo, Zhengfu Fan, Honglian Dai
Summary: Magnesium phosphate bone cement (MPC) is an artificial bone substitute with degradable properties and biocompatibility. By functionally modifying MPC with a CMCS/SA gel network, we improved its mechanical strength and optimized the interface for bone in-growth. The 2% CMCS/SA composite showed favorable physicochemical properties and promoted osteoblast cell attachment, proliferation, and osteogenic differentiation.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Kazuki Sasaki, Yoshiaki Ninomiya, Masaaki Takechi, Kanji Tsuru, Kunio Ishikawa, Hideo Shigeishi, Kouji Ohta, Tomonao Aikawa
Summary: The physical properties and antimicrobial release ability of antibiotic-loaded apatite cement/alpha-tricalcium phosphate composites were studied in vitro. The composites maintained the minimum inhibitory concentration of gentamicin against Staphylococcus aureus for 30 days. This suggests that the gentamicin-loaded composites have potential as a drug delivery system.
Article
Engineering, Biomedical
Julia B. Cassel, Matheus C. Tronco, Beatriz A. de Melo, Fernanda dos Santos de Oliveira, Luis A. L. dos Santos
Summary: Bone defects in patients have become increasingly important in the development of disability in recent decades, affecting their quality of life. Surgical intervention is often necessary for large bone defects that have a low chance of self-repair. The use of α-TCP-based cements in minimally invasive procedures is being studied as a potential solution. However, these cements lack adequate mechanical properties for most orthopedic applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mohamed Abdin, Mostafa Mabrouk, Laila El-Sebaiy, Maher Eissa, Mohamed El-Bana, Mohamed Abdelbaset Salama, A. E. El-Beltagy, Mohamed Ahmed Naeem
Summary: The study aimed to develop biodegradable films using carboxymethyl cellulose (CMC), sodium alginate (SA), and Thymus vulgaris purified leaves extract (TVE). The addition of TVE up to 1.6% in the film matrix increased opacity, reduced moisture, swelling, solubility, and water vapor permeability (WVP). The surface micrographs showed smoother surface at low TVE concentrations and became irregular and rough at higher concentrations. The developed CMC/SA/TVE2 film showed significant effects on preserving the quality of cheddar cheese during cold storage compared to commercial packaging materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Piotr Pantak, Joanna P. Czechowska, Aneta Zima
Summary: Novel, hybrid alpha-TCP-based bone cements containing silane coupling agents were developed and examined. The use of silane coupling agents improved the physicochemical properties of the bone cements, such as increased compressive strength and reduced setting time. These findings demonstrate the beneficial influence of silane coupling agents on calcium phosphate-based bone substitutes.
Article
Materials Science, Ceramics
Runqing Liu, Bodong Fang, Guanhua Zhang, Jinbo Guo, Yuanquan Yang
Summary: This study investigated the impact of sodium alginate on the hydration properties of magnesium potassium phosphate cement suspension with a high water-to-cement ratio, and explored the mechanism behind its retarding effect. Sodium alginate was found to delay the dissolution and precipitation of key crystalline phases, leading to an extended setting time for the cement.
CERAMICS INTERNATIONAL
(2022)
Article
Biophysics
Ahmed El-Fiqi, Joong-Hyun Kim, Hae-Won Kim
Summary: The study successfully prepared highly bioactive bone cement microspheres, which have the potential to serve as bone defect fillers to promote bone regeneration. These microspheres have a large specific surface area, sustained release of soluble silicate ions, and high protein adsorption capacity. The experimental results demonstrate that these cement microspheres exhibit excellent bioactivity both in vitro and in vivo, accelerating new bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Maduru Suneetha, Hyeon Jin Kim, Sung Soo Han
Summary: In this study, bioactive phosphate-crosslinked sodium alginate-based hydrogels were designed and synthesized for biomineralization using a calcium-free approach. The hydrogels exhibited interconnected porous networks, improved swelling and biodegradable properties, and excellent bone-like apatite formation abilities under simulated body fluid conditions.
Article
Engineering, Biomedical
Haosheng He, Haohao Ren, Zhengwen Ding, Mizhi Ji, Hong Chen, Yonggang Yan
Summary: The novel magnesium calcium phosphate/sodium alginate composite cements with proper setting time and high compressive strength show potential as bone repair candidate materials, as they can induce deposition of Ca-P layer and promote proliferation and differentiation of bone marrow mesenchymal stem cells. The cements gradually degrade in PBS and exhibit weight loss up to 20.74% by the end of 56th day.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Inna V. Fadeeva, Dina V. Deyneko, Katia Barbaro, Galina A. Davydova, Margarita A. Sadovnikova, Fadis F. Murzakhanov, Alexander S. Fomin, Viktoriya G. Yankova, Iulian V. Antoniac, Sergey M. Barinov, Bogdan I. Lazoryak, Julietta V. Rau
Summary: Gadolinium-containing calcium phosphates with different synthesis methods have distinct physical and chemical properties, exhibit inhibition effects on bacteria and fungi, and show no toxicity to cells.
Article
Chemistry, Physical
Yuanquan Yang, Bodong Fang, Guanhua Zhang, Jinbo Guo, Runqing Liu
Summary: This study investigated the effects of a candidate retarder, sodium alginate, on the hydration and properties of magnesium potassium phosphate cements (MKPCs). The results showed that 1% sodium alginate could effectively extend the setting time and improve the early strength of MKPCs. Sodium alginate had minimal impact on the formation of hydration products in the long term, but it did reduce the compressive strength of MKPCs.
Review
Engineering, Biomedical
Furqan A. Shah
Summary: Whitlockite, a unique calcium phosphate, is mainly found in pathological calcification of soft tissues. Despite claims in the synthetic bioceramics community, evidence suggests that it is exclusively a pathological biomineral and does not constitute a biomimetic strategy for bone repair.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Environmental
Fupo He, Teliang Lu, Songheng Feng, Yao Wang, Changgui Huang, Yihang Zhang, Xin Deng, Jiandong Ye
Summary: The study demonstrated that TCP/PGs scaffolds containing gallium and strontium have significant effects on cell proliferation, osteogenic differentiation, and osteoclastic activities. While gallium alone inhibited bone resorption but did not promote bone formation, the addition of strontium enhanced bone regeneration after implantation in rabbit femoral defects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Ceramics
Szymon Skibinski, Ewelina Cichon, Katarzyna Harazna, Elena Marcello, Ipsita Roy, Malgorzata Witko, Anna Slosarczyk, Joanna Czechowska, Maciej Guzik, Aneta Zima
Summary: This study successfully achieved controlled drug release by coating beta-tricalcium phosphate-based porous scaffolds with diclofenac-functionalized biopolymer. The composite showed improved mechanical properties and bioactive potential, making it a promising multifunctional scaffold for anti-inflammatory drug delivery in bone tissue engineering.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Karolina Feliksiak, Daria Solarz, Maciej Guzik, Aneta Zima, Zenon Rajfur, Tomasz Witko
Summary: This study explores the impact of PLA and P(3HO) on cellular response, focusing on the role of VIF and identifying two different types of vimentin cytoskeleton architecture expressed by cells depending on substrate features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Joanna Czechowska, Ewelina Cichon, Anna Belcarz, Anna Slosarczyk, Aneta Zima
Summary: This study developed bioactive bone substitutes with antibacterial properties, incorporating gold nanoparticles and silicon-modified tricalcium phosphate. The biomicroconcretes showed good mechanical performance and antimicrobial activity, making them suitable for medical applications.
Article
Biochemistry & Molecular Biology
Szymon Skibinski, Joanna P. Czechowska, Ewelina Cichon, Martyna Seta, Agata Gondek, Agnieszka Cudnoch-Jedrzejewska, Anna Slosarczyk, Maciej Guzik, Aneta Zima
Summary: The search for new materials for bone regeneration is continuing. This study presents newly constructed composites based on beta tricalcium phosphate (beta TCP) and a bacteria-derived biopolymer called poly(3-hydroxybutyrate) (P(3HB)). The composites were in the form of 3D scaffolds with different pore sizes. The researchers employed a pre-treatment using citric acid to improve polymer attachment to the beta TCP surface. This pre-treatment increased surface roughness and created micropores that facilitated polymer adhesion. The developed materials have the potential for bone tissue regeneration and were found to promote cell migration and viability under lowered oxygen conditions. Adhesion of mesenchymal stem cells (MSCs) was facilitated by hydrophilic ceramic protrusions in the composites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Ewelina Cichon, Joanna P. Czechowska, Malgorzata Krok-Borkowicz, Sarah L. Allinson, Karolina Stepien, Alan Smith, Elzbieta Pamula, Timothy E. L. Douglas, Aneta Zima
Summary: The use of biosurfactants as additives to calcium phosphate cements (CPCs) to create highly porous foamed materials is a novel idea. These compounds are popular due to their biological activity, such as anti-cancer or antibacterial properties. The functionalization of CPCs with non-ionic biosurfactants led to the development of highly porous materials with good mechanical strength and maintained the bioactive potential of the cements. This study sheds new light on the use of biosurfactants in CPCs and provides a foundation for further research, particularly in vivo studies.
BIOMATERIALS ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Piotr Pantak, Joanna P. Czechowska, Ewelina Cichon, Aneta Zima
Summary: This study investigated the influence of liquid phase composition on the physicochemical properties of double hybrid-type bone substitutes. The solid phase of the biomicroconcretes was composed of highly reactive α-tricalcium phosphate powder (α-TCP) and hybrid hydroxyapatite/chitosan granules (HA/CTS). Different combinations of disodium phosphate solution and citrus pectin gel were used as liquid phases. The novelty of this research lies in the development of double hybrid materials with a dual setting system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Piotr Pantak, Joanna P. Czechowska, Aneta Zima
Summary: Novel, hybrid alpha-TCP-based bone cements containing silane coupling agents were developed and examined. The use of silane coupling agents improved the physicochemical properties of the bone cements, such as increased compressive strength and reduced setting time. These findings demonstrate the beneficial influence of silane coupling agents on calcium phosphate-based bone substitutes.
Article
Green & Sustainable Science & Technology
Szymon Skibinski, Joanna P. Czechowska, Maciej Guzik, Vladyslav Vivcharenko, Agata Przekora, Patryk Szymczak, Aneta Zima
Summary: Poly(3-hydroxybutyrate) (P(3HB)) and medium chain length PHA (mcl-PHA) blends were used as coatings on beta tricalcium phosphate (beta TCP) scaffolds, and their physicochemical properties were investigated. The blends showed high open porosity and improved compressive strength on the scaffolds. The wettability of the coatings could be tailored by modifying the composition of the blends. In vitro biocompatibility tests showed that all evaluated scaffolds were nontoxic, and the hydrophilicity of the surface positively influenced cell adhesion and proliferation.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Ewelina Cichon, Bartosz Mielan, Elzbieta Pamula, Anna Slosarczyk, Aneta Zima
Summary: A novel method of producing highly porous cements using nonionic surfactants was studied in this research. Different surfactants were tested for their cytotoxicity and optimal concentration, with Tetronic 90R4 showing the lowest toxicity. The type of surfactant used affected the physical, chemical, and biological properties of the macroporous cement, with Tween 80 producing the highest porosity and compressive strength. In vitro studies confirmed the stability and bioactive potential of the materials.
