Article
Cell Biology
Rui Wang, Wenchao Hu
Summary: The study demonstrated that asprosin induces apoptosis in beta-cells by inhibiting autophagy. High glucose and asprosin both lead to increased apoptosis and altered expression of certain proteins in MIN6 cells, affecting the AMPK-mTOR signaling pathway. Activation of the AMPK pathway by AICAR partially reverses the effects of asprosin on autophagy and apoptosis in beta-cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Liu, Jun Tao, Yueyi Yao, Ping Yang, Juhui Wang, Mali Yu, Jianhong Hou, Ying Zhang, Li Gui
Summary: Resveratrol promotes osteoblast proliferation by increasing GATA-1 expression, which activates autophagy. Additionally, AMPKα acts as an important upstream regulator in this process.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Eunok Im, Nam Deuk Kim
Summary: This paper comprehensively summarizes the effects of resveratrol on inducing programmed cell death (PCD) such as apoptosis, autophagy, and necroptosis, as well as the development of synthetic resveratrol derivatives and analogues as novel anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jiaqiao Li, Yameng Fan, Yan Zhang, Yamei Liu, Yan Yu, Mao Ma
Summary: Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer A549 cells, and this process is regulated by the NGFR-AMPK-mTOR signaling pathway.
Article
Reproductive Biology
Haolin Li, Xiaomeng Pei, Hao Yu, Wei Wang, Dagan Mao
Summary: This study investigated the effects of APN/AdipoRon on autophagy and apoptosis in goat luteal cells, and found that autophagy and apoptosis play important roles in the structural regression of goat corpus luteum.
Article
Pharmacology & Pharmacy
Lin Guo, Yupei Liang, Shiwen Wang, Lihui Li, Lili Cai, Yongqing Heng, Jing Yang, Xing Jin, Junqian Zhang, Shuying Yuan, Tong Xu, Lijun Jia
Summary: JB induces apoptosis and autophagy in human breast cancer cell lines, mediated by NOXA and AMPK signaling pathway. In vivo study confirms JB's anti-breast cancer effect by suppressing tumor growth. Autophagy plays a pro-survival role in attenuating apoptosis induced by JB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Reproductive Biology
Jing Pang, Hua Yang, Xu Feng, Qi Wang, Yu Cai, Zifei Liu, Changjian Wang, Feng Wang, Yanli Zhang
Summary: HT-2 toxin exerts toxic effects on goat spermatogonial stem cells, leading to decreased cell viability and proliferation, disruption of self-renewal ability, and induction of cell apoptosis and oxidative stress. Additionally, HT-2 toxin exposure also induces autophagy in goat SSCs, possibly through the AMPK-mTOR-ULK1 pathway.
Article
Biochemistry & Molecular Biology
Yeli Zhao, Jingjing Lin, Jiana Li, Canol Bwalya, Yuyun Xu, Yue Niu, Yujie Zhang, Junyi Wu, Yifan Xu, Jun Chen, Shasha Ye, Li Lin
Summary: This study found that UVB irradiation promoted the expression of fibroblast growth factor 21 (FGF21) protein in mouse epidermal cells, and exogenous recombinant human FGF21 (rhFGF21) protected mouse skin tissue against UVB-induced injury by inhibiting inflammatory responses, apoptosis, and promoting autophagy. Moreover, rhFGF21 protected HaCaT cells against UVB-induced apoptosis by inducing AMPK-mediated autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Shunan Tang, Sina Cai, Shuai Ji, Xiaojin Yan, Weijia Zhang, Xue Qiao, Hongquan Zhang, Min Ye, Siwang Yu
Summary: Isoangustone A induces cell death through activation of AMPK-mediated autophagy, inhibiting tumor growth. Further investigation is warranted for its potential as an anti-cancer agent.
Article
Oncology
Shan Ren, Lei Shen, Song Lin, Dan Xiao, Wei Xiao, Pei-Mei Yan, Yan-Yan Zhang, Wei-Wei Jia, Yan Lin
Summary: Resveratrol inhibits cardiac hypertrophy by regulating autophagy and apoptosis signaling pathways, leading to improved cardiac function.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao
Summary: This study demonstrates that crocin can protect LO2 cells from TGF-beta-induced injury by promoting proliferation and autophagy, suppressing apoptosis and anti-inflammation, and regulating the AMPK/m-TOR signaling pathway.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Xiaocong Xiang, Yunhong Tian, Jiani Hu, Rong Xiong, Matthew Bautista, Li Deng, Qiuju Yue, Yuqi Li, Wei Kuang, Junfeng Li, Kang Liu, Chunlei Yu, Gang Feng
Summary: Fangchinoline (Fan) induces apoptosis and autophagy in colorectal cancer cells by activating the AMPK/mTOR/ULK1 signaling pathway, inhibiting tumor growth both in vitro and in vivo, and showing potential as a promising anticancer agent.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Norah Saeed Al-Zahrani, Mazin Abdulaziz Zamzami, Mohammed A. Baghdadi, Afnan H. El-Gowily, Ehab M. M. Ali
Summary: Combining metformin and paclitaxel shows promising outcomes in the treatment of liver cancer. It enhances treatment effectiveness, reduces side effects, induces cell cycle alterations and apoptosis, as well as modulates key cellular proteins involved in cancer growth.
Article
Chemistry, Multidisciplinary
Xu-Dong Mao, Ting -Ting Du, Qi Gu, Li Yang, Hai-Lian Shi, Ran Hong, Gui-Xin Chou
Summary: Nepetaefolin F, a compound, exhibited significant inhibition against human cancer cells with an IC50 value of 6.3 μM. The synthesis of Nepetaefolin F and its analogues were performed, and one analogue, cyclopropanecarboxylate ester 42, showed significant antitumor activity against MGC 803 cells with an IC50 value of 20.9 μM. Further studies revealed that compound 42 could regulate multiple signaling pathways related to autophagy, such as PPAR and AMPK, and induce cell apoptosis in MGC 803 cells by inhibiting cell proliferation and autophagy.