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Biochemistry & Molecular Biology
Tie-Gang Meng, Wen-Long Lei, Xukun Lu, Xiao-Yu Liu, Xue-Shan Ma, Xiao-Qing Nie, Zheng-Hui Zhao, Qian-Nan Li, Lin Huang, Yi Hou, Ying-Chun Ouyang, Lei Li, Tie-Shan Tang, Heide Schatten, Wei Xie, Shao-Rong Gao, Xiang-Hong Ou, Zhen-Bo Wang, Qing-Yuan Sun
Summary: This study reveals that the absence of maternal Ehmt2 leads to infertility in mice. Further investigations demonstrate that EHMT2 regulates meiotic progression in mouse oocytes by controlling the transcription of Ccnb3.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
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Cell Biology
Jian Li, Hong-Yong Zhang, Feng Wang, Qing-Yuan Sun, Wei-Ping Qian
Summary: This research demonstrates that the cyclin B2/CDK1 complex conservatively regulates separase activity through inhibitory phosphorylation in both meiosis I and meiosis II of mouse oocytes, influencing chromosome segregation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Debabrata Das, Swathi Arur
Summary: This article reviews the roles of cell cycle regulators and the extracellular signal-regulated kinase (ERK) signaling pathway in oocyte maturation. By studying different species, the conserved and distinct functions of ERK signaling during oocyte maturation can be understood.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
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Cell Biology
Song Yang, Youguang Luo, Mulin Yang, Hua Ni, Hanxiao Yin, Ming Hu, Min Liu, Jun Zhou, Yunfan Yang, Dengwen Li
Summary: Src is a key player in cell division, migration, adhesion, and survival. Its overactivation in tumors promotes cancer cell survival and mitosis. Src is conserved across species and its inhibition leads to abnormal expression of chromosomal passenger complex components, resulting in multipolar spindle formation and cell division failure. The findings suggest that Src inhibitors can be used as a novel approach for cancer treatment.
CELL AND TISSUE RESEARCH
(2023)
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Biology
Caroline Kratka, David Drutovic, Cecilia S. Blengini, Karen Schindler
Summary: This study reveals the importance of a specific kinase family in the process of miscarriage, as it regulates chromosome segregation and affects meiotic progression. The use of an inhibitor leads to defects in meiosis and spindle building, further emphasizing the significance of this kinase in reproductive health.
BMC RESEARCH NOTES
(2022)
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Plant Sciences
Sorin Tanasa, Neha Shukla, Albert Cairo, Ranjani S. Ganji, Pavlina Mikulkova, Sona Valuchova, Vivek K. Raxwal, Claudio Capitao, Arp Schnittger, Zbynek Zdrahal, Karel Riha
Summary: Meiosis is a specialized cell division that reduces the number of chromosomes, followed by mitotic divisions to form haploid gametophytes in angiosperm plants. In Arabidopsis, the termination of meiosis and transition to gametophytic development are regulated by TDM1 and SMG7, which inhibit translation. Mutants deficient in this mechanism show aberrant nuclear divisions due to the failure to downregulate cyclin dependent kinases during meiotic exit. A mutation in cyclin-dependent kinase D;3 (CDKD;3) was identified as a suppressor that alleviates meiotic defects in smg7 deficient plants by preventing aberrant meiotic divisions or delaying their onset. CDKD;3 acts independently of CDKA;1 and interacts with proteins involved in cytokinesis, suggesting a complex role in cell cycle regulation.
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Biochemistry & Molecular Biology
Kim S. McKim
Summary: The chromosome passenger complex (CPC) plays a crucial role in spindle assembly and error correction by interacting with chromatin and microtubules. These dual interactions enhance CPC concentration for efficient kinase activity and responsiveness to specific conditions in the cell. CPC-microtubule interactions are vital for processes such as meiotic division and metaphase I error correction.
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Biochemistry & Molecular Biology
Yan Zhu, Liang Rong, Qiang Luo, Baihui Wang, Nana Zhou, Yue Yang, Chi Zhang, Haiyang Feng, Lina Zheng, Wen-Hui Shen, Jinbiao Ma, Aiwu Dong
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Biotechnology & Applied Microbiology
Gao-Feng Qiu, Hai-Yang Feng, Keisuke Yamano
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
(2009)
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Plant Sciences
Minjie Weng, Yue Yang, Haiyang Feng, Zongde Pan, Wen-Hui Shen, Yan Zhu, Aiwu Dong
PLANT CELL AND ENVIRONMENT
(2014)
Article
Plant Sciences
Pengfei Sui, Jing Jin, Sheng Ye, Chen Mu, Juan Gao, Haiyang Feng, Wen-Hui Shen, Yu Yu, Aiwu Dong
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Multidisciplinary Sciences
Xueling Yao, Bojie Fu, Yihe Lu, Feixiang Sun, Shuai Wang, Min Liu
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Cell Biology
Haiyang Feng, Martina Raasholm, Alexandra Moosmann, Coen Campsteijn, Eric M. Thompson
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Genetics & Heredity
Haiyang Feng, Yao-Ting Dong, Xue Liu, Gao-Feng Qiu
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Cell Biology
Yao-Ting Dong, Hai-Yang Feng, Xiao-Qing Tian, Qi-Liang Wang, Shu-Fang Zhang, Ke-Yi Ma, Gao-Feng Qiu
Summary: A new germ cell-specific marker, MnTdrd RNA, was identified and found to be expressed abundantly in ovaries and embryos. The localization pattern of MnTdrd transcripts resembled that of the previously identified germ cell marker vasa, suggesting a preformation mode of germ cell specification. MnTdrd may play critical roles in germ cell formation and differentiation in prawns, serving as a novel germ cell marker for tracing their origin and migration.
DEVELOPMENT GENES AND EVOLUTION
(2021)
Article
Cell Biology
Ying Chen, Xiang Fang, Xiao-Qing Tian, Zheng Cui, Hai-Yang Feng, Gao-Feng Qiu
Summary: The study demonstrated the identification of germ plasm and PGCs in the prawn Macrobrachium nipponense using Vasa protein as a marker, showing that PGCs could be specified from the 16-cell stage. The continuous expression of Vasa protein suggests its important role in early germ cell specification.
CELL AND TISSUE RESEARCH
(2021)