Journal
CELL BIOLOGY INTERNATIONAL
Volume 42, Issue 2, Pages 132-138Publisher
WILEY
DOI: 10.1002/cbin.10879
Keywords
cellular mechanics; desmin; filamin C; intermediate filaments; lamin (A; C); plectin
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Funding
- Mahron-Stiftung
- German Science Foundation (DFG) [Go598]
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Intermediate filaments (IFs) are one of the three types of cytoskeletal polymers that resist tensile and compressive forces in cells. They crosslink each other as well as with actin filaments and microtubules by proteins, which include desmin, filamin C, plectin, and lamin (A/C). Mutations in these proteins can lead to a wide range of pathologies, some of which exhibit mechanical failure of the skin, skeletal, or heart muscle.
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