Article
Environmental Sciences
Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang
Summary: Sulforaphane (SFN), extracted from cruciferous plants, plays a vital role in eliminating oxidative free radicals and protecting cells through activation of the Nrf2-mediated signaling pathway. This study found that SFN can attenuate paraquat-induced damage to bovine in vitro-matured oocytes and enhance their maturation and fertilization rates. SFN reduces oxidative stress, inhibits cell apoptosis, and activates antioxidative-related genes through the Nrf2 pathway, providing novel evidence for the protective role of SFN against paraquat-induced injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agriculture, Multidisciplinary
Xuan Zhang, Yuanyuan Chen, Hongmin Li, Baobao Chen, Zhaojun Liu, Gang Wu, Chengyu Li, Rongyang Li, Yan Cao, Jiaqi Zhou, Ming Shen, Honglin Liu, Jingli Tao
Summary: The study found that Sulforaphane can alleviate the adverse effects of hypoxia on porcine granulosa cells by activating antioxidant defenses and mitophagy through nuclear factor erythroid 2-related factor 2 (NFE2L2).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marija Petkovic, Ermelindo C. Leal, Ines Alves, Chanda Bose, Philip T. Palade, Preeti Singh, Sanjay Awasthi, Elisabet Borsheim, Louise T. Dalgaard, Sharda P. Singh, Eugenia Carvalho
Summary: The study found that dietary supplementation with SFN increased antioxidant capacities and gene expression related to the Nrf2 pathway in the skin of old mice. Protein levels for Nrf2 were also increased, while ROS and MMP9 levels decreased significantly. Furthermore, collagen deposition was improved in young mice and significantly improved in old mice with SFN treatment, indicating that SFN can ameliorate skin aging.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gaoqing Xu, Yangyunyi Dong, Zhe Wang, He Ding, Jun Wang, Jing Zhao, Hongyu Liu, Wenfa Lv
Summary: The study found that melatonin can promote mitophagy and inhibit oxidative-stress-induced apoptosis and mitochondrial injury in bovine ovarian granulosa cells through the SIRT1/FoxO1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Dan Shao, Wenxiang Shen, Yuyang Miao, Zhen Gao, Menghao Pan, Qiang Wei, Zuoting Yan, Xiaoe Zhao, Baohua Ma
Summary: The study found that sulforaphane (SFN), a phytochemical compound, has a preventive effect on LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in primary goat mammary epithelial cells and a mouse model of mastitis, which may improve prevention strategies for mastitis in dairy goats.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
He Ding, Zhiqiang Li, Xin Li, Xiaorui Yang, Jing Zhao, Jing Guo, Wenfa Lu, Hongyu Liu, Jun Wang
Summary: This study investigates the mechanism of cadmium-induced damage to granulosa cells and its association with m(6)A modification. The findings suggest that cadmium exposure reduces cell viability, increases apoptosis and oxidative stress, and alters the expression of various enzymes and proteins involved in cell damage. The AKT pathway and MNT gene may play important roles in this process. The study highlights the significance of m(6)A modification in cadmium toxicity to granulosa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Maryam Taheri, Nasim Hayati Roudbari, Fardin Amidi, Kazem Parivar
Summary: This study examined the protective effect of Sulforaphane (SFN) through the activation of the AMPK/AKT/NRF2 pathway against oxidative stress (OS) in granulosa-lutein cells (GLCs). The results showed that SFN treatment decreased ROS and apoptosis levels and increased the overexpression of AMPK, AKT, and NRF2 genes and proteins, suggesting its protective effects against OS in GLCs.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chand Basha Davuljigari, Frederick Adams Ekuban, Cai Zong, Alzahraa A. M. Fergany, Kota Morikawa, Gaku Ichihara
Summary: The activation of Nrf2 signaling pathway provides protection against acrylamide-induced neurotoxicity by suppressing oxidative stress and inflammation. Nrf2 remains an important target for the strategic prevention of acrylamide-induced neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mengjiao Chen, Yumeng Xi, Kunlin Chen, Peng Xiao, Shujie Li, Xiaochun Sun, Zhaoyu Han
Summary: SESN2, a conservative oxidative stress protein, plays a crucial role in regulating energy metabolism, cell proliferation, apoptosis, and mitochondria autophagy. Knockout of SESN2 exacerbates apoptosis and oxidative damage, while its overexpression decreases apoptosis and blocks oxidative damage in MAC-T cells treated with H2O2. Additionally, SESN2 can alleviate oxidative stress and cell apoptosis by activating the Keap1-Nrf2/ARE pathway in H2O2-treated MAC-T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Tauber, Maria Katharina Sieckmann, Katrin Erler, Wilhelm Stahl, Lars-Oliver Klotz, Holger Steinbrenner
Summary: The study found that the Se status had no major effect on Nrf2 signaling in HepG2 cells, although electrophiles could enhance the expression of Nrf2 target genes independent of cellular Se status.
Review
Nutrition & Dietetics
Scott E. Liebman, Thu H. Le
Summary: This article discusses the impact of oxidative stress in chronic kidney disease and the role of the Nrf2 pathway in kidney disease, as well as the promising therapeutic potential of sulforaphane.
Article
Environmental Sciences
Xiaoqiao Wang, Zhanjun Lv, Bing Han, Siyu Li, Qingyue Yang, Pengfei Wu, Jiayi Li, Biqi Han, Ning Deng, Zhigang Zhang
Summary: The study aimed to explore the adverse effects and potential mechanisms of DBP exposure on rat lungs, finding that DBP promoted inflammatory damage, increased apoptosis and oxidative stress, and upregulated inflammatory cytokines. Conversely, sulforaphane ameliorated the pulmonary damage induced by DBP.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Ya Zhang, Qifang Wu, Jian Liu, Zhongshan Zhang, Xiaojing Ma, Yaoyue Zhang, Jiawen Zhu, Ronald W. Thring, Mingjiang Wu, Yitian Gao, Haibin Tong
Summary: Sulforaphane extracted from high-risk diet can improve insulin resistance by increasing glucose uptake and insulin signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Mohamed Omar Taqi, Mohammed Saeed-Zidane, Samuel Gebremedhn, Dessie Salilew-Wondim, Ernst Tholen, Christiane Neuhoff, Michael Hoelker, Karl Schellander, Dawit Tesfaye
Summary: This study found that bovine granulosa cells exposed to oxidative stress induced by H2O2 exhibited differential expression of various transcription factors, which are mediated by the NRF2 signaling pathway.
CELL AND TISSUE RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Liyuan Zhou, Changchen Hu, Yujun Li, Binquan Wang
Summary: This study investigated the therapeutic effect of Sulforaphane (SFP) on hypoxic vestibular vertigo (HVV) using a rat model. The results showed that SFP treatment helped to maintain the balance of escape latency and concentrations of nitric oxide (NO), glutathione (GSH) and superoxide dismutase (SOD), and restored the inhibited expression of NRF2. SFP treatment also increased the production of NO and cyclic guanosine monophosphate (cGMP) in a dose-dependent manner.
Review
Medicine, Research & Experimental
Md Mahmodul Hasan Sohel
Correction
Multidisciplinary Sciences
Yu Imai, Kirsten J. Meyer, Akira Iinishi, Quentin Favre-Godal, Robert Green, Sylvie Manuse, Mariaelena Caboni, Miho Mori, Samantha Niles, Meghan Ghiglieri, Chandrashekhar Honrao, Xiaoyu Ma, Jason J. Guo, Alexandros Makriyannis, Luis Linares-Otoya, Nils Boehringer, Zerlina G. Wuisan, Hundeep Kaur, Runrun Wu, Andre Mateus, Athanasios Typas, Mikhail M. Savitski, Josh L. Espinoza, Aubrie O'Rourke, Karen E. Nelson, Sebastian Hiller, Nicholas Noinaj, Till F. Schaeberle, Anthony D'Onofrio, Kim Lewis
Article
Agriculture, Dairy & Animal Science
Adi Ratriyanto, Sigit Prastowo, Nuzul Widyas
Summary: The study found that combined supplementation with ASD and betaine improved the quails' growth performance during the starter period, but did not affect ovarian and follicular characteristics during the onset of the laying period. However, ASD and betaine were effective in enhancing egg production and weight.
Article
Plant Sciences
I. Dewa M. Kresna, Zerlina G. Wuisan, Jean-Marie Pohl, Ute Mettal, Virginia Linares Otoya, Martin Gand, Michael Marner, Luis Linares Otoya, Nils Bohringer, Andreas Vilcinskas, Till F. Schaeberle
Summary: A biosynthetic gene cluster encoding an azinothricin-like compound was identified, and the production yield was enhanced by overexpression of a transcriptional activator. The structures of two compounds were successfully isolated and elucidated.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Lei Wang, Virginia Linares-Otoya, Yang Liu, Ute Mettal, Michael Marner, Lizbeth Armas-Mantilla, Sabine Willbold, Tibor Kurtan, Luis Linares-Otoya, Till F. Schaeberle
Summary: The bacterial genus Tenacibaculum plays various ecological roles in marine environments, with one strain producing six new antimicrobial alkaloids with strong or moderate activity against different microorganisms. The biosynthetic route of these compounds was investigated, and similar compounds were found in other Tenacibaculum species.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Agronomy
Nuzul Widyas, Tri Satya Mastuti Widi, Sigit Prastowo, Ika Sumantri, Ben J. Hayes, Heather M. Burrow
Summary: This paper reviews the literature on cattle breeding in tropical environments, particularly Indonesia. The aim is to find new breeding opportunities for smallholder farmers in Indonesia while conserving local cattle beef breeds. The lack of well-designed breeding programs in Indonesia has resulted in many mixed-breed animals with unknown genetic composition and adaptation capabilities. Crossbreeding programs are too complex for smallholder farmers, but within-breed selection could be used to develop tropically adapted composite breeds. International collaborations and the use of genomic information are crucial for genetic improvement and conservation of unique Indonesian cattle breeds.
Article
Agriculture, Dairy & Animal Science
S. Prastowo, R. Widyastuti
Summary: This study investigated the effect of using CO2 exhaled by human and GSH on oocyte maturation. The results showed that using CEbH supports oocyte maturation, and the addition of GSH can improve the maturation rate.
JOURNAL OF THE INDONESIAN TROPICAL ANIMAL AGRICULTURE
(2022)
Article
Agriculture, Dairy & Animal Science
A. Masykur, A. Ratriyanto, N. Widyas, S. Prastowo
Summary: This study used logistic, Gompertz, and Adams-Bell nonlinear models to analyze the effects of dietary supplementation with silica+ and betaine on egg production of quail in a tropical environment. The results showed that supplementation with betaine increased egg production and the production curve was more stable. The Gompertz model was found to be suitable for describing the egg production pattern.
EUROPEAN POULTRY SCIENCE
(2022)
Article
Ecology
N. Widyas, A. Raharjo, R. Setiaji, D. Prasetiyo, R. D. Hapsari, Y. Suparman, S. Prastowo
Summary: This study aimed to provide a reliable method to predict the body weight of Bali cattle. Analysis of 1051 records showed that a linear model with CG, BL, and WH as predictors had better model fit than a model with only CG, and both models demonstrated reliable prediction ability.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
A. Masykur, S. Prastowo, N. Widyas, A. Ratriyanto
Summary: The research showed that methionine supplementation in quail's diet consistently increases egg weight, indicating a positive effect on egg weight consistency.
7TH INTERNATIONAL CONFERENCE ON SUSTAINABLE AGRICULTURE AND ENVIRONMENT
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
D. M. Nuraini, S. Prastowo, N. Widyas
Summary: This study compared reproductive performance of Jawarandu goat serviced naturally and artificially, with natural service showing better reproductive performance.
7TH INTERNATIONAL CONFERENCE ON SUSTAINABLE AGRICULTURE AND ENVIRONMENT
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
S. Prastowo, I. F. I. Widowati, D. M. Nuraini, N. Widyas
Summary: This study aimed to predict heterozygosity related to body weight traits through simulation of allele frequency changes in different crossbreeding scenarios of Indonesian goat breeds. The results demonstrate that crossbreeding can alter the heterozygosity of goat populations.
7TH INTERNATIONAL CONFERENCE ON SUSTAINABLE AGRICULTURE AND ENVIRONMENT
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
A. Ratriyanto, S. Prastowo, N. Widyas, C. Huda, A. Masykur, L. A. Pradista
Summary: Supplementing quails with a combination of betaine and silica+ can increase egg production, with the production curve showing a sharp rise soon after laying begins, and the T1 group achieving higher peak production. The logistic regression model can accurately predict egg production in quails.
7TH INTERNATIONAL CONFERENCE ON SUSTAINABLE AGRICULTURE AND ENVIRONMENT
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
N. Widyas, L. A. Pradista, R. Setiaji, R. D. Hapsari, S. Prastowo
Summary: This study compared the predictive accuracy of four cattle body weight prediction formulas and found that the predictive ability ranged from 84.90% to 89.68% in both male and female cattle groups, but all formulas had relatively high root mean square errors. Further research is needed to determine the potential bias introduced by using these predicted values as response variables.
7TH INTERNATIONAL CONFERENCE ON SUSTAINABLE AGRICULTURE AND ENVIRONMENT
(2021)
Article
Chemistry, Organic
I. Dewa Made Kresna, Luis Linares-Otoya, Tobias Milzarek, Elke R. Duell, Mahsa Mir Mohseni, Ute Mettal, Gabriele M. Koenig, Tobias A. M. Gulder, Till F. Schaeberle
Summary: This study investigates the biosynthetic steps of polychlorinated aromatic compounds ambigols A-E produced by the cyanobacterium Fischerella ambigua, revealing the key genes, enzymes, and substrate biosynthesis and conversion processes involved.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)