Article
Biochemistry & Molecular Biology
Sheila S. Fontes, Mateus L. Nogueira, Rosane B. Dias, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Marcos A. Vannier-Santos, Daniel P. Bezerra
Summary: This study investigated the combination of curcumin and disulfiram in the treatment of melanoma and found synergistic anti-tumor effects. The combination promoted apoptosis and DNA fragmentation in melanoma cells and increased oxidative stress. In animal experiments, the combination therapy inhibited tumor growth.
Article
Biochemistry & Molecular Biology
Xueying Ren, Yanchun Li, Yi Zhou, Wanye Hu, Chen Yang, Qiangan Jing, Chaoting Zhou, Xu Wang, Jiayu Hu, Luyang Wang, Jing Yang, Hairui Wang, Haifeng Xu, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du
Summary: DSF/Cu selectively exerts efficient cytotoxic effect on HCC cells, inhibits migration, invasion, and angiogenesis of HCC cells, impairs mitochondrial homeostasis, increases free iron pool, enhances lipid peroxidation, and eventually results in ferroptotic cell death. Inhibition of NRF2 elevation strengthens HCC cells more vulnerable to DSF/Cu induced ferroptosis.
Article
Engineering, Biomedical
Weijun Xu, Yaping Wang, Guanghui Hou, Jinlei Wang, Taibing Wang, Junmin Qian, Aili Suo
Summary: A copper-dithiocarbamate chelate-doped and artemisinin-loaded hollow nanoplatform is developed for cuproptosis-based combination therapy. The nanoplatform exhibits tumor microenvironment-triggered catalytic activity, depletes intracellular glutathione, and induces oxidative stress, thus sensitizing cancer cells to cuproptosis. Furthermore, the nanoplatform activates ferroptosis and triggers apoptosis, resulting in potent antitumor efficacy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Immunology
Minghuan Zhu, Zhenjing Liu, Yanhong Guo, Mst Sadia Sultana, Kang Wu, Xiaoe Lang, Qinyu Lv, Xiao Huang, Zhenghui Yi, Zezhi Li
Summary: This study revealed gender differences in the relationship between TNF-alpha, MDA, and their interaction with psychopathological symptoms in patients with schizophrenia. Male patients showed higher MDA levels and specific associations between TNF-alpha, MDA levels, and psychotic symptoms compared to female patients.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Sanaa A. Ahmed, Walaa Mohammed
Summary: The present study demonstrates that CARV has a protective effect against aluminum chloride-induced testicular oxidative, inflammatory, and apoptosis damage, including modulation of biochemical parameters, protection of sperm count and motility, improvement of histopathological findings, and restoration of the expression levels of apoptotic-related genes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Ruan Gabriel Soares da Silva, Mariane Okamoto Ferreira, Isabella Mitsu Suo Komori, Henrique Rodrigues Menezes Oliveira, Murilo Galvani Machado, Julia Fernandes Gois Orrutea, Fernanda Mara Alves, Hellen dos Santos Jaques, Janaina Carla da Silva, Janoario Athanazio de Souza, Daniel Rech, Carolina Panis
Summary: Studies have shown a high incidence of various tumors, including breast cancer, in populations exposed to pesticides. This exposure is not only associated with direct DNA damage but also with epigenetic modifications and inflammation mediators, indicating genomic instability. The present study analyzed the inflammatory changes in the breast tissue of occupationally exposed women without cancer and found an inflammatory signature associated with pesticide exposure, which may trigger genetic mutations and breast carcinogenesis.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Min Wei, Ying Cong, Jinrong Lei, Rui Du, Mengxin Yang, Xinjun Lu, Yizhu Jiang, Ran Cao, Xianzong Meng, Zhenfu Jiang, Laiyu Song
Summary: In this study, an in vitro co-culture system was used to investigate the mechanisms underlying the damage to the air-blood barrier after exposure to PM2.5. The study found that PM2.5 exposure induced oxidative stress and activated the NLRP3 inflammasome-mediated pyroptosis pathway. Inhibiting oxidative stress decreased pyroptosis and increased tight junction (TJ) protein levels. Additionally, the drug disulfiram reversed the adverse effects of PM2.5, suppressing pyroptosis and improving air-blood barrier dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Neurosciences
Zakieh Keshavarzi, Sedigheh Amiresmaili, Nader Shahrokhi, Bahram Bibak, Farzane Shakeri
Summary: The study suggests that Auraptene may prevent complications of traumatic brain injury by reducing oxidative stress, decreasing levels of inflammatory cytokines, and inhibiting brain damage.
BRAIN RESEARCH BULLETIN
(2021)
Article
Engineering, Environmental
Ying Peng, Peng Liu, Jinsong Ding, Wenhu Zhou
Summary: This study explores the potential of combining DSF, Cu2+, and Ca2+ as a promising approach for treating tumors. By developing biomineralized nanoparticles that can release DTC, Cu2+, and Ca2+ in response to the acidic tumor microenvironment, the study demonstrates the amplified anti-tumor effects achieved through in-situ CuET generation and calcium overload.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Madhuri Basak, Kiran Das, Tarun Mahata, Abhishek Singh Sengar, Sumit Kumar Verma, Sayan Biswas, Kakali Bhadra, Adele Stewart, Biswanath Maity
Summary: This study investigates the role of RGS7 in hyperlipidemia-dependent hepatic dysfunction in NAFLD. RGS7 is found to be elevated in the livers of NAFLD patients and forms a complex with ATF3 and Tip60, contributing to NAFLD development. Knockdown of RGS7 protects against liver damage caused by high-fat diet, reversing steatosis and inflammation, and improving liver function.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, Research & Experimental
Claudia Morais Sequeira, Marcela Anjos Martins, Renata Alves, Ana Lucia Rosa Nascimento, Giuly Cristina Rodrigues Mello Botti, Vinicius Novaes Rocha, Cristiane Matsuura
Summary: The study demonstrated that aerobic exercise training could effectively prevent doxorubicin-induced cardiomyopathy and preserve cardiomyocyte ultrastructure, partially through activation of the physiological protein synthesis pathway and reduction of oxidative stress.
Review
Oncology
Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Sergey Klochkov, Ruitai Fan
Summary: Chronic inflammation and oxidative stress play crucial roles in cancer initiation and progression, contributing to the severity of cancer and metastasis. The overproduction of reactive oxygen species and inflammatory mediators can lead to DNA damage, mutations, and genomic instability, promoting tumor development. Recognition of these pathways provides opportunities for developing therapeutic interventions targeting multiple oncological and inflammation-related mechanisms simultaneously.
Article
Biochemistry & Molecular Biology
Simarjot Kaur Sandhu, Suneel Kumar, Jayant Raut, Mandeep Singh, Sandeep Kaur, Garima Sharma, Tomas L. Roldan, Sonia Trehan, Jennifer Holloway, Gabriella Wahler, Jeffrey D. Laskin, Patrick J. Sinko, Francois Berthiaume, Bozena Michniak-Kohn, Praveen Rishi, Narayanan Ganesh, Indu Pal Kaur
Summary: This study aimed to develop high drug-loaded curcumin solid lipid nanoparticles (CSLNs) for wound healing, showing superior drug release properties and antimicrobial effects. The CSLNs exhibited excellent safety, stability, controlled release, and disruption of mature biofilms, both in vitro and in vivo.
Article
Environmental Sciences
Sameh Mohamed Farouk, Fatma Abdel-monem Gad, Mahmoud Abdelghaffar Emam
Summary: The study demonstrated that basil and sesame seed oils have protective effects against the toxic effects of Diazinon in rats. These oils significantly decreased abnormal blood parameters, reduced oxidative stress, and modulated inflammatory and immune responses compared to rats exposed only to Diazinon. Additionally, basil oil showed a more potent protective effect at both immunohistochemical and molecular levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Shvetank Bhatt, Kuttiappan Anitha, Dinesh Kumar Chellappan, Dhrubojyoti Mukherjee, Satish Shilpi, Ashish Suttee, Gaurav Gupta, Thakur Gurjeet Singh, Kamal Dua
Summary: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that can lead to economic burden and poor quality of life. Variations in genes, Cortico-Striato-Thalamo-Cortical (CSTC) circuit dysfunction, and synaptic conduction dysregulation are major factors in the pathological progression of OCD. Current therapies targeting neurotransmitters have limited efficacy, and inflammation may play a crucial role in OCD. Targeting inflammatory signaling pathways may be a suitable approach for treatment.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Bipasa Kar, Chanakya Nath Kundu, Sanghamitra Pati, Debdutta Bhattacharya
Summary: Amid the rise of multi-drug resistance, finding new antibiotics is challenging. This study utilized molecular docking to screen and identify three phytocompounds with potential antimicrobial activity, outperforming the reference drug meropenem. The compounds showed competitive inhibition against the target proteins and demonstrated stability through molecular dynamics simulations. These findings suggest that the phytocompounds have potential as Metallo beta-lactamase inhibitors and warrant further in vitro and in vivo clinical trials.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Neurosciences
Shvetank Bhatt, Jovita Kanoujia, S. Mohana Lakshmi, CR. Patil, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua
Summary: The human gut microbiota has a significant impact on central nervous system-related diseases, including major depressive disorder (MDD). The imbalance of the brain-gut-microbiota axis plays a crucial role in the pathogenesis of depression. The regulation of gut microbiota is emerging as a new treatment modality for MDD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Cell Biology
Deepika Nayak, Subarno Paul, Chinmay Das, Subhasmita Bhal, Chanakya Nath Kundu
Summary: The role of ABCG2 in cancer progression, invasiveness, and recurrence is known, but its role in metastasis and angiogenesis is unclear. The study found that Curcumin and Quinacrine can inhibit the expression of ABCG2, thus reducing angiogenesis in breast cancer. This finding is significant for the treatment of breast cancer.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Letter
Dermatology
Gabriel J. Starrett, Jae W. Lee, Subhajit Chatterjee, Jaroslaw J. Jedrych
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tulshidas S. Patil, Nayan A. Gujarathi, Abhijeet A. Aher, Hemal E. Pachpande, Charu Sharma, Shreesh Ojha, Sameer N. Goyal, Yogeeta O. Agrawal
Summary: Psoriasis is a disease characterized by abnormal differentiation and excessive proliferation of epidermal keratinocytes, severely impacting patients' quality of life. Current treatment options provide only temporary relief with various adverse effects. Nanostructured lipid carriers (NLCs) have emerged as promising nanocarriers for psoriasis treatment due to their superior physicochemical properties. This manuscript provides an overview of psoriasis, its pathophysiology, existing treatment options, and limitations, highlighting the advantages, rationale, and mechanism of NLCs for psoriasis treatment. It also presents various NLC nanoformulations and relevant patents for psoriasis treatment, along with regulatory considerations. NLCs exhibit sustained drug release, the ability to incorporate hydrophobic and hydrophilic drugs, improved skin hydration, penetration, retention, and bioavailability, reduced staining potential, and decreased side effects compared to conventional ointments, indicating a bright future for NLC nanoformulations in psoriasis treatment. However, academic-industry collaboration and stricter regulatory controls are needed for the commercialization of NLC nanoformulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Shilu Deepa Thomas, Niraj Kumar Jha, Saurabh Kumar Jha, Bassem Sadek, Shreesh Ojha
Summary: Apigenin, a dietary flavonoid, has antioxidant, anti-inflammatory, anticancer, and antibacterial properties. It has shown potential therapeutic effects in the treatment of cardiovascular diseases such as atherosclerosis, stroke, hypertension, myocardial injury, and diabetic cardiomyopathy. This review focuses on the pharmacological mechanisms, therapeutic uses, and potential applications of apigenin in the treatment of cardiovascular disorders. Further research is needed to establish its safety and efficacy and explore its potential as a nutraceutical and therapeutic agent.
Article
Biochemistry & Molecular Biology
Fayez T. Hammad, Loay Lubbad, Suhail Al-Salam, Javed Yasin, Mohamed Fizur Nagoor Meeran, Shreesh Ojha, Waheed F. Hammad
Summary: Both ureteral obstruction and hypertension have significant impacts on kidney functions. Reversible ureteral obstruction in hypertensive rats showed exaggerated alterations in renal functions and other parameters of renal injury compared to normotensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rajalaxmi Pradhan, Subarno Paul, Biswajit Das, Saptarshi Sinha, Somya Ranjan Dash, Mahitosh Mandal, Chanakya Nath Kundu
Summary: Cancer-associated fibroblasts (CAFs) are highly abundant components in the tumor microenvironment (TME) that secrete cytokines to promote tumor progression and metastasis. This study investigated the potential of cytokines in the formation of cancer stem cells (CSCs) in oral cancer cells and evaluated the anti-inflammatory and anti-carcinogenic effect of Resveratrol-nanoparticle (Res-NP). The results showed that CXCL-12 and IL-6 secreted by CAFs significantly promoted CSCs growth and metastasis, while Res-NP inhibited their secretion and reduced CSCs growth and proliferation. This study suggests that targeting CXCL-12 and IL-6 with Res-NP can inhibit carcinogenesis and metastasis in oral cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Kunal Goutam, Chanakya Nath Kundu
Summary: In this study, the role of Quinacrine (QC) in the deregulation of cMET-mediated metastasis and angiogenesis was evaluated. The results showed that QC inhibited the proliferation, migration, invasion, and metastasis markers of cMET-overexpressed cells. Additionally, QC significantly inhibited angiogenesis in cMET-overexpressed cells by dephosphorylating cMET and downregulating its downstream cascade.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Chemistry, Medicinal
Madhuri Baghel, Kalyani Sakure, Tapan Kumar Giri, Sabyasachi Maiti, Kartik T. Nakhate, Shreesh Ojha, Charu Sharma, Yogeeta Agrawal, Sameer Goyal, Hemant Badwaik
Summary: Natural polysaccharides have excellent biocompatibility and fewer adverse effects, but it is challenging to compare their bioactivities with manufactured synthetics due to their intrinsic physicochemical characteristics. Carboxymethylation of polysaccharides can increase their solubility and bioactivities, but it has limitations that can be overcome through derivatization or grafting. These modifications improve the swelling, flocculation, viscosity, metal absorption properties, and thermosensitivity of natural polysaccharides. Researchers have modified carboxymethylated gums to create better and functionally enhanced polysaccharides. This review explores the impact of molecular modifications on their characteristics and applications.
Review
Biochemistry & Molecular Biology
Sumit S. Rathod, Yogeeta O. Agrawal, Kartik T. Nakhate, M. F. Nagoor Meeran, Shreesh Ojha, Sameer N. Goyal
Summary: Neuroinflammation is a complex biological process that originates as a protective response in the brain. The distribution of CB1 and CB2 cannabinoid receptors across different brain regions may play important roles in regulating neuroinflammatory processes.
Review
Materials Science, Biomaterials
Somya Ranjan Dash, Chanakya Nath Kundu
Summary: Viruses have a huge impact on healthcare and socio-economic growth as they are the leading cause of death from infectious diseases. Traditional drug use poses risks to public health, such as drug resistance and side effects. Therefore, developing new methods for virus-related disease treatment is necessary. Nanomaterial-based nanomedicines offer advantages over traditional treatments and show promise in anti-viral therapy. This review discusses biocompatible nanomaterials and their potential use in treating and preventing common viral illnesses.
BIOMATERIALS SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Christian Knackstedt, Georg Schummers, Joerg Schroeder, Nikolaus Marx, Joost Lumens, Sandra Sanders-van Wijk, Bram Ramaekers, Michael Becker, Vanessa van Empel, Hans-Peter Brunner-La Rocca
Summary: The Simpson's method is widely used for determining left ventricular ejection fraction (EF) in echocardiography. However, there is significant variability among different observers in measuring LVEF, which can be attributed to various factors including experience, observer position, and timing.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Review
Oncology
Subhasmita Bhal, Chanakya Nath Kundu
Summary: Wnt, Hedgehog (Hh), and Notch signaling pathways are crucial for embryonic development and have a significant role in maintaining stemness properties of cancer stem cells (CSCs) and promoting tumor progression. Inhibiting the growth and proliferation of CSCs is challenging, and novel therapeutic strategies targeting the crosstalk of these pathways are needed. This review focuses on the molecules involved in the interaction of Wnt, Hh, and Notch pathways, their role in enhancing CSCs properties, and potential therapeutic approaches. Additionally, the involvement of long non-coding RNAs (LncRNAs) and their modulation of these signaling pathways in CSCs maintenance are discussed. Overall, this review provides valuable insights for the development of new anti-CSCs drugs.
Article
Oncology
Chinmay Das, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Biswajit Das, Subhasmita Bhal, Chinmayee Sethy, Chanakya Nath Kundu
Summary: In this study, the effects of quinacrine and talazoparib on cancer stem cells were investigated in patient-derived oral mucosa CSCs and a xenograft mice model system. The results showed that the combination treatment inhibited the recruitment of PARP-1-mediated chromatin remodelers, preventing repair proteins from accessing damaged DNA. The treatment also inhibited topoisomerase activity, induced topological stress, and triggered apoptosis in CSCs.