Article
Cardiac & Cardiovascular Systems
Jiahui Fan, Huaping Li, Rong Xie, Xudong Zhang, Xiang Nie, Xiaolu Shi, Jiabing Zhan, Zhongwei Yin, Yanru Zhao, Beibei Dai, Shuai Yuan, Zheng Wen, Chen Chen, Dao Wen Wang
Summary: This study aimed to elucidate the role of lncRNA in dilated cardiomyopathy (DCM) and heart failure, with a focus on the ZNF593-AS molecule. Through a series of experiments and observations, the research demonstrated the critical function of ZNF593-AS in improving cardiac function in DCM, potentially offering a new avenue for therapeutic interventions in the future.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Laura Keil, Filip Berisha, Stella Ritter, Johanna Skibowski, Hariharan Subramanian, Viacheslav O. Nikolaev, Christian Kubisch, Rixa Woitschach, Larissa Fabritz, Raphael Twerenbold, Stefan Blankenberg, Soeren Weidemann, Tanja Zeller, Paulus Kirchhof, Daniel Reichart, Christina Magnussen
Summary: This study aims to phenotype and genotype the different subtypes of dilated cardiomyopathy (DCM) and lay the foundation for individualized therapy.
Article
Medicine, Research & Experimental
Liu Yang, Jianxin Deng, Wenxia Ma, Aijun Qiao, Shiyue Xu, Yang Yu, Chan Boriboun, Xiang Kang, Dunzheng Han, Patrick Ernst, Lufang Zhou, Jiawei Shi, Eric Zhang, Tao-Sheng Li, Hongyu Qiu, Shinichi Nakagawa, Seth Blackshaw, Jianyi Zhang, Gangjian Qin
Summary: The experiment shows that the deletion of Miat can alleviate pathological cardiac hypertrophy and heart failure, mainly by enhancing the contractility of cardiomyocytes.
Article
Medicine, Research & Experimental
Rong Xie, Jiahui Fan, Jianpei Wen, Kunying Jin, Jiabing Zhan, Shuai Yuan, Yuyan Tang, Xiang Nie, Zheng Wen, Huaping Li, Chen Chen, Dao Wen Wang
Summary: Diabetes can directly cause cardiac injury, leading to cardiomyopathy. In this study, the protective role of ZNF593-AS in diabetic cardiomyopathy was identified. ZNF593-AS attenuated cardiomyocyte apoptosis and inflammation by suppressing the phosphorylation and activation of IRF3, suggesting that ZNF593-AS may be a potential therapeutic target for diabetic cardiomyopathy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Immunology
Alireza Khatami, Mohammad Hossein Razizadeh, Monire Ghadirali, Shahrooz Yazdani, Saeed Bahadory, Alireza Soleimani
Summary: A significant association between Parvovirus B19 and myocarditis with a high prevalence was found, while no significant association was found with dilated cardiomyopathy.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Massaiu, Jeness Campodonico, Massimo Mapelli, Elisabetta Salvioni, Vincenza Valerio, Donato Moschetta, Veronika A. Myasoedova, Maria Domenica Cappellini, Giulio Pompilio, Paolo Poggio, Piergiuseppe Agostoni
Summary: By analyzing the gene expression profiles of iron-linked genes at the tissue and single-cell level in heart failure patients, it was found that the iron metabolism in cardiomyocytes is altered, including imbalanced iron ion internalization, decreased internal conversion, increased hemoglobin synthesis, elevated heme externalization, reduced heme cleavage, and up-regulated hepcidin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li Tan, Di Xiong, Hui Zhang, Sirou Xiao, Ruilan Yi, Jian Wu
Summary: Heart failure (HF) is a chronic disease characterized by inadequate blood and oxygen supply to peripheral tissues. This study investigated the mechanism of HF using H2O2-treated AC16 cells as a cellular model. The results showed that H2O2 stimulation increased the expression of ETS2, TUG1, and ATG7, while decreasing the expression of miR-129-5p. H2O2 stimulation also induced cardiomyocyte apoptosis and autophagy, which could be reversed by manipulating the ETS2/TUG1/miR-129-5p/ATG7 axis. Overall, these findings suggest that targeting this axis may provide new therapeutic options for treating HF.
Article
Biotechnology & Applied Microbiology
Shuo Wang, Tianjie Lv, Qincong Chen, Yan Yang, Lei Xu, Xiaolei Zhang, Enmao Wang, Xitian Hu, Yuying Liu
Summary: This study aimed to identify common molecular markers for cardiac fibrosis (CF) and heart failure (HF) to assist in diagnosis and treatment. Through gene sequencing and functional enrichment analysis, differentially expressed RNAs and key genes shared between CF and HF were identified. Potential diagnostic gene markers were also determined. Therefore, the identification of common molecular markers for CF and HF is of great significance in early prevention of CF transitioning into HF.
Article
Biochemistry & Molecular Biology
Manabu Shiraishi, Ken Suzuki, Atsushi Yamaguchi
Summary: Excess deposition of extracellular matrix in the myocardium is associated with reduced left ventricular function. The mechanisms underlying the reversal of fibrosis are not well understood. This study investigated the role of myocardial tissue elasticity in influencing fibroblast phenotype. In vitro experiments using different culture conditions showed that fibroblasts differentiated into activated or matrix-degrading types based on the pericellular environment. Gene expression analysis identified Selenbp1 as a key regulator of fibroblast differentiation. Knockdown of Selenbp1 enhanced fibroblast activation and inhibited matrix degradation. In vivo knockdown of Selenbp1 resulted in tissue fibrosis and diastolic failure in the left ventricle. Selenbp1 appears to be a major molecule involved in regulating collagen turnover in cardiac fibrosis.
Review
Pharmacology & Pharmacy
Yexiang Lin, Yujie Sheng, Jinlan Chen, Chengyu Hu, Zixian Zhou, Chengfu Yuan
Summary: LncRNA FTX is abnormally increased in various tumors, while its expression level decreases in certain diseases. FTX may be an important regulatory factor and a potential therapeutic target in cancers.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Kai Zhang, Min Wu, Xianyu Qin, Pengju Wen, Yueheng Wu, Jian Zhuang
Summary: By investigating the core genes related to ischemic cardiomyopathy and dilated cardiomyopathy, common molecular mechanisms between these two types of heart failure were identified, along with potential biomarkers that could be promising for heart failure diagnosis and treatment.
DNA AND CELL BIOLOGY
(2021)
Article
Cell Biology
Sixuan Wang, Jun Duan, Jiangquan Liao, Yan Wang, Xiang Xiao, Lin Li, Yi Liu, Huan Gu, Peng Yang, Dongliang Fu, Jinhang Du, Xianlun Li, Mingjing Shao
Summary: The study reveals that lncRNAH19 can attenuate DCM in DM by reducing cardiomyocyte apoptosis and improving fibrosis. Additionally, H19 can repress ERS, oxidative stress, and apoptosis, and this effect may be achieved by inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Article
Cardiac & Cardiovascular Systems
Nicola R. Pugliese, Francesco Paneni, Matteo Mazzola, Nicolo De Biase, Lavinia Del Punta, Luna Gargani, Alessandro Mengozzi, Agostino Virdis, Lorenzo Nesti, Stefano Taddei, Andreas Flammer, Barry A. Borlaug, Frank Ruschitzka, Stefano Masi
Summary: Echocardiographic epicardial adipose tissue (EAT) has different impacts and prognoses in heart failure (HF) patients, with high EAT levels associated with adverse effects in HFpEF patients and low EAT levels related to negative outcomes in HFrEF patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Job A. J. Verdonschot, Joao Pedro Ferreira, Pierpaolo Pellicori, Hans-Peter Brunner-La Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Nicolas Girerd, Beatrice Mariottoni, Johannes Petutschnigg, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Stephane R. B. Heymans
Summary: Among patients at risk for heart failure, diabetic individuals have higher levels of proteins related to inflammation and proteolysis in their plasma compared to non-diabetic patients. Treatment with spironolactone has similar effects on protein biomarkers in diabetic and non-diabetic patients, producing anti-fibrotic, anti-remodelling, blood pressure, and natriuretic peptide lowering effects regardless of diabetes status.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Pediatrics
Ting-Ting Li, Hao-Ying Li, Ji Cheng
Summary: This study found elevated serum UA levels in children with DCM, which are correlated with NYHA functional class and ultrasonic values. Changes in serum UA levels may serve as a biomarker reflecting the severity of DCM in children.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Wu He, Gang Yuan, Yu Han, Yongcui Yan, Gen Li, Chengcheng Zhao, Jingshan Shen, Xiangrui Jiang, Chen Chen, Li Ni, Dao Wen Wang
Summary: Long-term continuous use of glimepiride is associated with better survival, fewer hospitalizations and emergency visits for heart failure, and fewer hospitalizations for acute myocardial infarction or stroke. High-dose glimepiride has greater cardiovascular protective advantages than low-dose glimepiride. The cardiovascular protective effect of glimepiride may be related to the increase in epoxyeicosatrienoic acid levels through soluble epoxide hydrolase inhibition.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.
Review
Biology
Xiang Nie, Jiahui Fan, Dao Wen Wang
Summary: Cardiac fibrosis is a significant issue in cardiovascular diseases, with molecular mechanisms involving TGF-beta signaling, extracellular matrix synthesis and degradation, and non-coding RNAs. Long noncoding RNAs play a crucial role in myocardial fibrosis and can regulate fibrosis by affecting miRNA expression, TGF-beta signaling, and ECM synthesis. Understanding these mechanisms can guide the development of novel therapeutic strategies to prevent or reverse cardiac fibrosis.
Article
Biochemistry & Molecular Biology
Jiali Nie, Yu Han, Zhiyuan Jin, Weijian Hang, Hongyang Shu, Zheng Wen, Li Ni, Dao Wen Wang
Summary: Editing MYBPC3 gene using CRISPR/Cas9 system in vivo can rescue the phenotype of rats with hypertrophic cardiomyopathy. The editing corrected some mutations, restored MYBPC3 protein expression, and normalized the HCM phenotype.
Article
Cardiac & Cardiovascular Systems
Chen Chen, Wu He, Dao Wen Wang
Summary: In November 2019, Wuhan became the epicenter of the COVID-19 outbreak caused by the novel SARS-CoV-2 infection. The emergence of new strains and mutations of the virus posed a serious global health threat. COVID-19-associated cardiac injury, ranging from mild cases to fulminant myocarditis, is not uncommon, and the overactivated immune response and inflammatory storm play a crucial role in its pathogenesis. Early identification and diagnosis are crucial for the treatment of COVID-19-associated myocarditis.
Article
Oncology
Hong Yang, Rui Li, Fei Ma, Yujian Liu, Xingwei He, Qiao Yang, Dao Wen Wang, Hesong Zeng, Hong Wang
Summary: This study aimed to explore and determine whether echocardiographic phenotype provides value for further risk stratification and guiding treatment in AL patients with heart failure. The results showed that right ventricular wall thickness (RVT), relative wall thickness (RWT), and left ventricular ejection fraction (LVEF) < 50% were independently associated with survival. Survival was significantly reduced in the presence of RVT >= 6.5 mm or LVEF < 50%. Echocardiographic phenotype has incremental value beyond rMayo staging for predicting survival and guiding treatment in AL patients with heart failure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jiang He, Nanxiang Ouyang, Xiaofan Guo, Guozhe Sun, Zhao Li, Jianjun Mu, Dao Wen Wang, Lixia Qiao, Liying Xing, Guocheng Ren, Chunxia Zhao, Ruihai Yang, Zuyi Yuan, Chang Wang, Chuning Shi, Songyue Liu, Wei Miao, Guangxiao Li, Chung-Shiuan Chen, Yingxian Sun
Summary: This study tested the effectiveness of a non-physician community health-care provider-led intervention for hypertension. The results showed that this intervention can effectively reduce the risk of cardiovascular disease and death.
Review
Biology
Wu He, Ling Zhou, Ke Xu, Huihui Li, James Jiqi Wang, Chen Chen, DaoWen Wang
Summary: Myocarditis is an inflammatory cardiac disease that causes the destruction of myocardial cells, infiltration of inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis is expanding with the emergence of new pathogens and drugs. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis is gaining attention. Immunopathological processes play a significant role in the development and prognosis of myocarditis. Excessive immune activation can cause severe myocardial injury, while chronic inflammation can result in cardiac remodelling and dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis remains controversial, and immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and provides new perspectives on immunomodulatory therapies.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Summary: Intensive glycemic control is insufficient for reducing the risk of heart failure in patients with diabetes mellitus. MiR-320 and CD36 mutually enhance each other's expression, forming a positive feedback loop that sustains a hyperlipidemic state in the heart.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, Research & Experimental
Rong Xie, Jiahui Fan, Jianpei Wen, Kunying Jin, Jiabing Zhan, Shuai Yuan, Yuyan Tang, Xiang Nie, Zheng Wen, Huaping Li, Chen Chen, Dao Wen Wang
Summary: Diabetes can directly cause cardiac injury, leading to cardiomyopathy. In this study, the protective role of ZNF593-AS in diabetic cardiomyopathy was identified. ZNF593-AS attenuated cardiomyocyte apoptosis and inflammation by suppressing the phosphorylation and activation of IRF3, suggesting that ZNF593-AS may be a potential therapeutic target for diabetic cardiomyopathy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Jiaqi Dai, Tao Wang, Ke Xu, Yang Sun, Zongzhe Li, Peng Chen, Hong Wang, Dongyang Wu, Yanghui Chen, Lei Xiao, Hao Liu, Haoran Wei, Rui Li, Liyuan Peng, Ting Yu, Yan Wang, Zhongsheng Sun, Dao Wen Wang
Summary: Previous studies have identified differences in symptom severity and prognosis among patients with hypertrophic cardiomyopathy (HCM), suggesting the presence of potential HCM subtypes. In this study, consensus clustering was performed on echocardiography features of 793 HCM patients to identify potential subtypes. Machine learning modeling and interactome network detection techniques were used to explore the relationship between phenotype and genotype based on whole-exome sequencing data. Two subtypes were identified: subtype 2 characterized by stable course with asymmetric septal hypertrophy, and subtype 1 characterized by aggressive progression and left ventricular systolic dysfunction. Machine learning modeling based on personal whole-exome data accurately predicted subtype propensities using 46 genes with high mutation burden. Another cohort replicated the findings, showing increased left ventricular end-diastolic diameter and reduced ejection fraction in patients predicted as subtype 1. Echocardiography and genetic screening for the 46 genes can be used to classify HCM into two subtypes with distinct clinical outcomes.
FRONTIERS OF MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Zuowen He, Xin Xu, Qu Zhao, Hu Ding, Dao Wen Wang
Summary: This article summarizes the characteristics, etiology, diagnosis, and treatment of vasospastic angina (VSA), with a focus on the role of inflammation. It provides new insights into the understanding of VSA.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Huihui Li, Mingzhi Zhang, Quanyi Zhao, Wanqing Zhao, Yan Zhuang, Jin Wang, Weijian Hang, Zheng Wen, Li Wang, Chen Chen, Dao Wen Wang
Summary: This study reveals the pathogenesis of fulminant myocarditis (FM) and suggests potential therapeutic strategies. Healthy cardiomyocytes lose their function and differentiate into pro-angiogenic and pro-inflammatory cells in FM. Neutrophils, after migrating to the heart, continuously attract peripheral neutrophils via specific signals, resulting in their acute accumulation in the heart. Moreover, neutrophils can amplify the inflammatory response by recruiting and activating pro-inflammatory cells. Blockade of the self-recruiting loop of neutrophils substantially alleviates FM in mice.
Article
Cardiac & Cardiovascular Systems
Mei-Yan Dai, Yong-Cui Yan, Lu-Yun Wang, Chun-Xia Zhao, Dao-Wen Wang, Jian-Gang Jiang
Summary: Retrospective analysis of 150 patients with fulminant myocarditis revealed marked ECG abnormalities, including significantly decreased QRS amplitudes and various arrhythmias, which can serve as preliminary clues for the diagnosis of this condition.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yanru Zhao, Huaping Li, Hengzhi Du, Zhongwei Yin, Mengying He, Jiahui Fan, Xiang Nie, Yang Sun, Huiying Hou, Beibei Dai, Xudong Zhang, Yuanyuan Cai, Kunying Jin, Nan Ding, Zheng Wen, Jiang Chang, Chen Chen, Dao Wen Wang
Summary: This study found that KSHV infection is a risk factor for dilated cardiomyopathy, and the KSHV-encoded miRNA kshv-miR-K12-1-5p may be involved in the development of heart disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)