Article
Medicine, General & Internal
Jin Li, Zhao Sha, Xiaolan Zhu, Wanru Xu, Weilin Yuan, Tingting Yang, Bing Jin, Yuwei Yan, Rui Chen, Siqi Wang, Jianhua Yao, Jiahong Xu, Zitong Wang, Guoping Li, Saumya Das, Liming Yang, Junjie Xiao
Summary: MiR-30d is decreased in pathological cardiac hypertrophy and its overexpression can ameliorate hypertrophic phenotypes by regulating target genes MAP4K4 and GRP78 and inhibiting NFAT. MiR-30d is reduced in the serum of patients with chronic heart failure and its overexpression significantly improves pathological hypertrophy in human embryonic stem cell-derived cardiomyocytes.
Review
Cardiac & Cardiovascular Systems
Xing-Huai Huang, Jia-Lu Li, Xin-Yue Li, Shu-Xia Wang, Zhi-Han Jiao, Si-Qi Li, Jun Liu, Jian Ding
Summary: miR-208a plays a key role in regulating heart development and function, and is involved in cardiac pathogenesis, conduction system regulation, myofiber gene expression, and systemic energy homeostasis. Despite its critical functions, the regulatory networks involving miR-208a are still not fully understood, and further research is needed to clarify its diverse and potentially opposite roles in different molecular contexts.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Linfeng Li, Xiangwang He, Min Liu, Libing Yun, Bin Cong
Summary: This study found that cardiac miR-126-5p and miR-499a-5p were downregulated in CAD-SCD patients, and their combination had good diagnostic capabilities. These miRNAs are expected to serve as novel biomarkers for CAD-SCD and help differentiate the detailed causes in SCD cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Dongyun Li, Mingzhi Shen, Xinxin Deng, Yongyi Bai
Summary: The upregulation of miR-27a-3p plays a significant role in the progression of cardiac hypertrophy, promoting hypertrophy by targeting NOVA1.
Article
Cell Biology
Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu
Summary: This study reveals the association between miR-21 and pressure overload-induced cardiac remodeling in aged hearts. It suggests the potential therapeutic role of miR-21 in treating cardiac diseases in elderly individuals.
Article
Neurosciences
Zhoujing Yang, Sheng Hu, Yinbin He, Ling Ji
Summary: In this study, it was found that BUP-induced neurotoxicity in human neural cells could be regulated by the epigenetic axis of LINC00665 / hsa-miR-34a-5p. By exploring the functional mechanism of LINC00665 in regulating BUP-induced neurotoxicity, the study provides insights into potential therapeutic targets for neurologic dysfunctions induced by excessive application of local anesthetics.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biotechnology & Applied Microbiology
Ying Ding, Jingyu Wang, Jun Lu
Summary: The study demonstrated that silence of miR-337-5p attenuates cardiac hypertrophy by targeting UBQLN1, revealing a potential new therapeutic target in the modulation of mTOR signaling.
Article
Biochemistry & Molecular Biology
Yan Fang, Yu Tao, Haiwen Zhou, Hengli Lai
Summary: Research has shown that the relationship between cardiac hypertrophy and Celf1, miR-129-5p, and circ-Jarid2 is significant. MiR-129-5p plays an inhibitory role in cardiac hypertrophy, while Circ-Jarid2 promotes it.
Article
Biotechnology & Applied Microbiology
Jun Pan, Zhenjun Xu, Guanjun Guo, Can Xu, Zhizhao Song, Kunsheng Li, Kai Zhong, Dongjin Wang
Summary: This study revealed the involvement of circNfix in regulating cardiac hypertrophy, acting through the miR-145-5p/ATF3 axis. Overexpression of circNfix could prevent the progression of cardiac hypertrophy, suggesting a potential role as a molecular target for cardiac hypertrophy treatment.
Article
Biotechnology & Applied Microbiology
Lara Ottaviani, Rio P. Juni, Ricardo C. de Abreu, Marida Sansonetti, Vasco Sampaio-Pinto, Julie Halkein, Jana C. Hegenbarth, Nadja Ring, Kevin Knoops, Jordy M. M. Kocken, Carlos de Jesus, Auriane C. Ernault, Hamid El Azzouzi, Frank Ruhle, Serve Olieslagers, Hugo Fernandes, Lino Ferreira, Luca Braga, Monika Stoll, Diana S. Nascimento, Leon J. de Windt, Paula A. da Costa Martins
Summary: miR-200c-3p in extracellular vesicles secreted by cardiac myocytes plays a crucial role in the communication between cardiac cells and endothelial cells, affecting cardiac function and disease development.
Article
Cell Biology
Hongtao Shi, Hao Li, Fan Zhang, Honghong Xue, Yanan Zhang, Qinghua Han
Summary: In this study, miR-26a-5p was found to play an inhibitory role in cardiac hypertrophy by targeting ADAM17. The miR-26a-5p-ADAM17 cardiac hypertrophy axis presents a new molecular mechanism for understanding and potentially treating cardiac hypertrophy.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Cell Biology
Peilei Lu, Danyu Zhang, Fan Ding, Jialu Ma, Yang K. Xiang, Meimi Zhao
Summary: This study identified a new circRNA, circCacna1c, in cardiac hypertrophy, and demonstrated its role in promoting ISO-induced pathological hypertrophy through the miR-29b-2-5p/NFATc1 axis. These findings provide new insights into the regulatory mechanisms of circRNAs in cardiac hypertrophy.
Article
Cell Biology
Qingqing Wu, Qiuxiang Chen, Juan Wang, Di Fan, Heng Zhou, Yuan Yuan, Difei Shen
Summary: The study revealed that noncoding RNA Pvt1 and miR-196b play important roles in modulating cardiomyocyte hypertrophy and remodeling through regulating OSMR. This provides a rationale for further investigation into the potential therapeutic benefits of the lncRNA-miRNA-mRNA network in cardiac and cardiomyocyte hypertrophy.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Linlin Zhao, Feng Qi, Dongdong Du, Naishi Wu
Summary: Our study found that KDM3C promotes cardiac hypertrophy through epigenetic modification. Specifically, KDM3C upregulates miR-200c-3p expression and suppresses GAS5 expression, leading to increased miR-495-3p expression and repression of PHF8 transcription, ultimately contributing to the development of cardiac hypertrophy.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Satoshi Kawaguchi, Bruno Moukette, Marisa N. Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K. Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J. Conway, Il-man Kim
Summary: miR-150 is downregulated during heart failure and correlates with patient outcomes. It protects against myocardial infarction by reducing cardiomyocyte apoptosis and targets small proline-rich protein 1a. Knockdown of SPrr1a improves cardiac dysfunction and fibrosis post-MI.
CELL DEATH & DISEASE
(2023)
Article
Genetics & Heredity
Shicheng Li, Ronghua Yang, Xiao Sun, Shuncheng Miao, Tong Lu, Yuanyong Wang, Yang Wo, Wenjie Jiao
Article
Oncology
Yang Wo, Shicheng Li, Yuanyong Wang, Tong Lu, Yi Qin, Xiao Sun, Wenjie Jiao
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Oncology
Yang Wo, Yandong Zhao, Tong Qiu, Shicheng Li, Yuanyong Wang, Tong Lu, Yi Qin, Guisong Song, Shuncheng Miao, Xiao Sun, Ao Liu, Dezhi Kong, Yanting Dong, Xiaoliang Leng, Wenxing Du, Wenjie Jiao
Article
Multidisciplinary Sciences
Yuanyong Wang, Tong Lu, Yang Wo, Xiao Sun, Shicheng Li, Shuncheng Miao, Yanting Dong, Xiaoliang Leng, Wenjie Jiao
Article
Chemistry, Multidisciplinary
Zeyu Luo, Guosheng Tang, Hossein Ravanbakhsh, Wanlu Li, Mian Wang, Xiao Kuang, Carlos Ezio Garciamendez-Mijares, Liming Lian, Sili Yi, Junlong Liao, Maobin Xie, Jie Guo, Zongke Zhou, Yu Shrike Zhang
Summary: This study presents a technique that utilizes cryoprotective bioink to enable direct extrusion bioprinting in the vertical direction. The unique vertical 3D cryo-bioprinting technique allows the creation of freestanding constructs with anisotropic microchannels, enhancing cell viability and growth. This technique has broad applications in interface tissue engineering and shows potential in tissue engineering, regenerative medicine, drug discovery, and personalized therapeutics.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Liming Lian, Cuiping Zhou, Guosheng Tang, Maobin Xie, Zixuan Wang, Zeyu Luo, Julia Japo, Di Wang, Jianhua Zhou, Mian Wang, Wanlu Li, Sushila Maharjan, Marina Ruelas, Jie Guo, Xunwei Wu, Yu Shrike Zhang
Summary: The study introduces a vertical embedded extrusion bioprinting technique that allows precise control of vertical structure characteristics and successfully reconstructs key structures of intestinal villi and hair follicles, partially restoring functionality in vitro.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Junlong Liao, Changqing Ye, Jie Guo, Carlos Ezio Garciamendez-Mijares, Prajwal Agrawal, Xiao Kuang, Julia Olga Japo, Zixuan Wang, Xuan Mu, Wanlu Li, Terry Ching, Luis Santiago Mille, Cun Zhu, Xingcai Zhang, Zhongze Gu, Yu Shrike Zhang
Summary: A printable CPC ink was developed and used with a 3D printing system to create CPC superstructures with complex structures and structural colors. The performance of the printed objects could be easily adjusted by modifying ink composition and printing parameters. This technology opens up possibilities for applications such as intelligent color displays and 3D integrated sensors.
Article
Engineering, Biomedical
Mian Wang, Wanlu Li, Zeyu Luo, Guosheng Tang, Xuan Mu, Xiao Kuang, Jie Guo, Zhibo Zhao, Regina Sanchez Flores, Zewei Jiang, Liming Lian, Julia Olga Japo, Amir M. Ghaemmaghami, Yu Shrike Zhang
Summary: This study proposes a bioink with anti-bacterial and anti-inflammatory properties, which exhibits excellent printability and cytocompatibility. By incorporating AgGNRs and IL-4-loaded MSCs, the bioink also demonstrates anti-infection behavior and immunomodulatory function.
Article
Oncology
Yang Wo, Yizhou Peng, Zhigang Wu, Pengcheng Liu, Yan Shang, Xuxia Shen, Yihua Sun
Summary: This study developed a novel predictive model for individualized prediction of the survival benefit of postoperative radiotherapy in malignant pleural mesothelioma patients. The model was able to compensate for the weaknesses in the TNM staging system.
Article
Pharmacology & Pharmacy
J. Guo, W. -Z. Zhang, Q. Zhao, J. -S. Wo, S. -L. Cai
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2017)
Article
Cardiac & Cardiovascular Systems
Eric A. Shikatani, Tao Wang, Luke S. Dingwell, Colin White-Dzuro, Abdul Momen, Mansoor Husain
Summary: This study found that GDF5 deficiency can reduce the incidence of cardiac rupture after myocardial infarction and improve survival rates in mice. Additionally, GDF5 deficiency leads to increased myocardial fibrosis and decreased afterload. However, it also results in the occurrence of chronic adverse remodeling.
CARDIOVASCULAR PATHOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Martin Kveton, Lukas Hudec, Ivan Vykopal, Matej Halinkovic, Miroslav Laco, Andrea Felsoova, Wanda Benesova, Ondrej Fabian
Summary: This comprehensive review explores the transformative role of digital pathology and computational pathology, especially through machine learning, in the field of heart transplantation. These methodologies have the potential to enhance diagnostic outcomes and reduce observer variability by extracting valuable information from large datasets beyond human perceptual capabilities. However, challenges such as limited sample sizes, diverse data sources, and the absence of standardized protocols hinder the widespread adoption of these techniques.
CARDIOVASCULAR PATHOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Summary: This study examined the prevalence and characteristics of Lambl excrescences (LEs) in 403 healthy human hearts and found that the prevalence of LEs in healthy hearts is far lower than previously reported.
CARDIOVASCULAR PATHOLOGY
(2024)