Journal
FITOTERAPIA
Volume 105, Issue -, Pages 151-155Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.06.022
Keywords
Stachybotrys bisbyi; Hypocreales; Meroterpenoid; Seco-bisabosqual; Cytotoxic activities
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Funding
- Ministry of Science and Technology of China [2012ZX09301002-003001006]
- Natural Science Foundation of China [81422054, 81373306]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (Hao Gao)
- Jinan University
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Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3-5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic analyses, modified Mosher's method, and quantum chemical CD method. The cytotoxic activities of all compounds were tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines. (C) 2015 Elsevier B.V. All rights reserved.
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