Journal
FITOTERAPIA
Volume 106, Issue -, Pages 1-6Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.07.017
Keywords
Salvia urmiensis; Triterpenoids; Absolute configuration; Anti-proliferative activity
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Funding
- Iran National Science Foundation (INSF) [93025512]
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Two new triterpenoids, urmiensolide B (1) and urmiensic acid (2), with rare carbon skeletons together with three known compounds were isolated from the aerial parts of Salvia urmiensis Bunge, an endemic species of Iran. The structures were established by a combination of 1D and 2D NMR, and HRESIMS, and in the case of 2 and 3, their structures were confirmed by single-crystal X-ray analysis. The absolute configuration of 2 was established by electronic circular dichroism (ECD) spectra. The new compounds were evaluated for their anti-proliferative activities against A549 and MCF-7 human cancer cell lines. Compounds 1 and 2 showed IC50 values of 2.8 and 1.6 mu M against MCF-7 cells, respectively. (C) 2015 Elsevier B.V. All rights reserved.
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