Journal
CARBOHYDRATE POLYMERS
Volume 183, Issue -, Pages 11-20Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.11.033
Keywords
Antihyperlipidemic activity; Antioxidant activity; Cyclocarya paliurus; Hepatoprotective effect; Polysaccharide
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Funding
- National Natural Science Foundation of China [31560459, 31160319]
- Natural Science Foundation of Jiangxi Province, China [20151BAB204037]
- Science Funds of Educational Commission of Jiangxi Province, China [KJLD13027, GJJ13281]
- Graduate Innovative Special Fund Projects of Jiangxi Province, China [YC2015-S176]
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The objective of this study was to analyse the structure of CPP-2, and to observe the pharmacological effects of CPP-2 on lipid metabolism and oxidative stress. CPP-2, eluted as two main fractions comprised of two polysaccharides with Mw of 307 and 3.7 kDa, was mainly consisted of rhamnose, mannose, glucose and galactose in a molar ratio of 1.00: 0.78: 3.22: 0.45. The results showed that treatment with CPP-2 could improve blood lipid levels (TC, TG, HDL-C and LDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, GSH-PX, MDA and LPO). In addition, the histopathological observations of mice livers and the GPT activities indicated that CPP-2 could attenuate liver cell injury. The present findings demonstrated that CPP-2 might be effective in lowering lipid and protecting against HFE-induced hyperlipidemia and non-alcoholic fatty liver.
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