Article
Biochemistry & Molecular Biology
Duc Hung Nguyen, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Pierre-Simon Bellaye, Bertrand Collin, Odile Chambin, Marie-Aleth Lacaille-Dubois
Summary: A phytochemical study of Cordyline fruticosa Fairchild red from Vietnam led to the isolation of fourteen steroidal glycosides, including twelve previously undescribed and two known ones. The structures of these compounds, mainly spirostanol and furostanol glycosides, were elucidated through spectroscopic analysis. The isolated compounds were evaluated for their cytotoxicity against 4T1 cell line derived from a mouse mammary gland tissue.
Article
Plant Sciences
Jianhua Chen, Lili Li, Peiwen Tian, Wei Xiang, Xuan Lu, Rongshao Huang, Liangbo Li
Summary: Endophytic fungi have the potential to enhance the growth and secondary metabolite production of medicinal plants like Bletilla striata. Co-culture of B. striata with certain endophytic fungi led to significant improvements in plant growth and phenolic compound accumulation. The fungi were able to produce plant growth-promoting substances and modulate plant defense responses to optimize active component accumulation.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Agronomy
Ran Liu, Xuehua Han, Jing Gao, Min Luo, Dale Guo, Guangzhi Wang
Summary: Penicillium oxalicum strain was isolated from the tubers of Bletilla striata (Thunb.) Reichb. f. The solid-state fermentation products were concentrated by percolation extraction. Separation and purification of the ethyl acetate extracts were conducted using preparative HPLC. Based on spectrometry, 17 known compounds were determined. Compounds 1-3, 5, 7-8, 11-12, 14-17 were first found and isolated from this endophyte.
Article
Biochemistry & Molecular Biology
Yang Liu, Pengcheng Qiu, Minchang Wang, Yunyang Lu, Hao He, Haifeng Tang, Bang-Le Zhang
Summary: Paris mairei, a unique species in the genus Paris, is a rich source of steroidal saponins with various bioactivities, traditionally used as folk medicine in Southwest China. Through chemical methods and modern spectra analysis, new steroidal saponins were isolated from its rhizomes and evaluated for cytotoxicity against human pancreatic adenocarcinoma cell lines.
Article
Plant Sciences
Lan Jiang, Mengfei Lin, Han Wang, Hui Song, Lin Zhang, Qingyu Huang, Renrui Chen, Cheng Song, Guohui Li, Yunpeng Cao
Summary: This study presents a high-quality haplotype-resolved genome of B. striata and explores its genomic evolution and polysaccharide biosynthesis, providing important insights into the evolution of orchids and the improvement of medicinal value in B. striata.
Article
Plant Sciences
Caixia Wang, Min Tian, Ying Zhang
Summary: In this study, the miRNAs involved in asymbiotic seed germination in Bletilla striata were characterized using comparative small RNA sequencing. A total of 253 known and 125 novel miRNAs were identified, with 71 known and 29 novel miRNAs showing distinct expression among different stages. Functional analysis revealed that miRNA- target regulations play a critical role in important processes during germination, such as signaling, biosynthesis, and transport of plant hormones.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agricultural Engineering
Jidong Lu, Zhen Wang, Lihong Qin, Jiayu Shen, Zhen He, Qingsong Shao, Ding Lin
Summary: Bletilla striata flowers were subjected to different drying methods, with freeze drying demonstrating the best color protection effect and microwave drying being the fastest. In terms of antioxidant capacity, both natural drying and freeze drying showed high levels, with freeze drying being the optimal choice for overall preservation. Industrial production may benefit from using infrared drying due to cost considerations.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Microbiology
Chenghong Xiao, Chunyun Xu, Jinqiang Zhang, Weike Jiang, Xinqing Zhang, Changgui Yang, Jiao Xu, Yongping Zhang, Tao Zhou
Summary: This study compared the agronomic traits and accumulation of secondary metabolites in B. striata grown in different soil types, and found that soil type can affect the growth and secondary metabolite accumulation of B. striata, and that these effects are related to the soil microbial communities.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Xiaoxia Ma, Kehua Tang, Zhonghai Tang, Aiwen Dong, Yijun Meng, Pu Wang
Summary: In this study, the authors analyzed the roots, tubers, and leaves of B. striata by integrating transcriptome sequencing and untargeted metabolic profiling data. They investigated five different metabolic pathways involved in polysaccharide, sterol, flavonoid, terpenoid, and alkaloid biosynthesis, presenting organ-specific expression patterns of enzyme-coding genes and accumulation levels of metabolic intermediates. The data presented in this study could provide a molecular basis for further research on breeding and medicinal uses of B. striata.
Article
Biochemistry & Molecular Biology
Wen-Yi Ma, Jing Xie, Ling-Ling Yu, Shi-Juan Zhang, Wei Ni, Huan Yan, Hai-Yang Liu
Summary: The phytoconstituents of the 70% aqueous ethanol extract of Ypsilandra thibetica Franch. were investigated for their hemostatic activity. Fourteen previously unreported spirostanol saponins, ypsilandrosides Z1-Z14, and nine known analogues were isolated and characterized. Five spirostanol tetraglycosides showed favorable inducing platelet aggregation activities, with ypsilandroside G (16) exhibiting significant activity. The structure-activity relationship of these spirostanol glycosides' hemostatic activity was also discussed.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jia-Xin Lai, Yue Zhao, Wen-Ke Gao, Li-Hua Zhang, Hai-Yang Yu, Wen-Zhi Yang, Hong-Hua Wu
Summary: In this study, several steroidal compounds were isolated from the whole plants of Solanum lyratum Thunb. These compounds were evaluated for their cytotoxic activities against colon SW480 and hepatoma Hep3B cells. The results showed that nine compounds and the plant extract displayed significant activity against both cell lines, while twelve compounds showed strong inhibition against SW480 cells. This research provides valuable chemical markers for discrimination of Solanum plants and reveals diverse steroidal constituents in S. lyratum, which have potential applications in cancer treatment.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Materials Science, Multidisciplinary
Bingqi Zhu, Wen Cheng, Kai Zhao, Zhengbo Hu, Fangmei Zhou, Mingyuan Zhou, Chaodong Qian, Zhishan Ding
Summary: In this study, Bletilla striata polysaccharides (BSP)-based spongy dressings incorporated with zeolite were developed to address the limited bioactivity and lack of fixation of zeolite as a wound dressing. The composite dressings exhibited significant hemostatic effect in vivo and in vitro, reducing the thermal effect caused by zeolite. They also showed antibacterial activity and promoted wound healing through regulation of inflammation. The developed composite dressing has potential applications in hemostasis and wound healing.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Applied
Yang Liu, Na Tang, Xiao-Ying Qian, Tian-Yi Li, Qian Zhang, Peng-Cheng Qiu, Hai-Feng Tang, Yun-Yang Lu, Bang-Le Zhang
Summary: Four new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1-4), along with four known spirostanol saponins (5-8), were isolated from the roots of Paris verticillata. Their structures were determined through extensive spectroscopic analysis and chemical evidence. The discovery of compounds 1-4 expands the diversity and complexity of this spirostanol saponin family. Saponins 5 and 6 exhibited cytotoxicity against two human glioma cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
Qing Guo, Bailei Li, Chunling Bao, Yixia Li, Yuling Cao, Chunxiao Wang, Wenhui Wu
Summary: The study investigates the bioactivity of Bletilla striata polysaccharides (BSPS) in platelet aggregation and anti-inflammation. Results show that BSPS promotes platelet aggregation with an anti-inflammatory effect, indicating its potential benefits in the treatment of hemostasis and inflammatory diseases.
Article
Biochemistry & Molecular Biology
Nagwan M. Gabr, Neveen S. Ghaly, Suzan A. Mina
Summary: Three steroidal saponins were isolated from the leaves of Agave desmetiana hort, characterized and tested for cytotoxic activity, with one of the compounds showing the most potent cytotoxicity against tested cell lines.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
