Journal
FITOTERAPIA
Volume 105, Issue -, Pages 254-259Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.07.013
Keywords
Selaginella involven; Selaginella; Flavonoids; Apigenin derivatives; HUVECs
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Funding
- National Natural Science Foundation [31370370]
- Science and Technology Program of Hunan Provincial Science and Technology Department [2013SK5077]
- Social Development and Technology Specific Program of Hainan [SF201419]
- Postgraduates innovation subject of Central South University [2014zzts319]
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Six new flavonoids, involvenflavones A-F (1-6), were isolated from Selaginella involven. Their structures were elucidated based on UV, IR, 1D and 2D NMR as well as HR-ESI-MS techniques. All compounds belong to apigenin derivatives with 3'-aryl substituent This is the first report of the apigenin derivatives with 3'-aryl substituent from nature resources. These compounds also exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro. (C) 2015 Elsevier B.V. All rights reserved.
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