Article
Biochemistry & Molecular Biology
Chaemoon Lim, Ao Xuan Zhen, Sungwoo Ok, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun
Summary: This study found that hesperidin can inhibit high glucose-induced apoptosis and mitigate oxidative stress and endoplasmic reticulum stress. It also promotes cell survival through modulation of the mitogen-activated protein kinase signaling pathway.
Article
Pharmacology & Pharmacy
Mengru Ding, Zhiyan Tang, Wei Liu, Taili Shao, Pingchuan Yuan, Kaoshan Chen, Yuyan Zhou, Jun Han, Jing Zhang, Guodong Wang
Summary: Studies have shown that burdock fructooligosaccharide (BFO) can protect NRK-52E cells against damage induced by high glucose by inhibiting apoptosis and oxidative stress. The anti-oxidative stress effects of BFO are related to the inhibition of reactive oxygen species production, stabilization of mitochondrial membrane potential, and increased antioxidant activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Wenjun Li, Hongxia Xiao
Summary: This study demonstrated that DHM exerts protective effects against HG-induced oxidative stress and apoptotic damage in ARPE-19 cells through inhibition of miR-34a expression, suggesting its potential as a therapeutic agent for the treatment of DR.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Wenyu Zou, Bingkun Liu, Yulu Wang, Fangbin Shi, Shuguang Pang
Summary: This study found that metformin stimulates the proliferation of pancreatic islet endothelial cells and inhibits apoptosis and oxidative stress caused by high glucose levels. By activating the FXR/VEGF-A/eNOS pathway, metformin increases the expression of VEGF-A and eNOS, improves nitric oxide production, and decreases ROS production. These findings provide a new mechanism underlying the islet-protective effect of metformin.
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the effect of Boswellia serrata gum resin extract on endometriotic lesions in a rat model of endometriosis. The results showed that the extract reduced the size of the lesions and exerted antioxidant and antiapoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joseph Bagi Suleiman, Mahaneem Mohamed, Ainul Bahiyah Abu Bakar, Zaida Zakaria, Zaidatul Akmal Othman, Victor Udo Nna
Summary: This study demonstrates that bee bread has therapeutic effects on oxidative stress, apoptosis, and inflammation in the testis of obese rats.
Article
Medicine, General & Internal
Pei Zhang, Jing Liao, Xiaoju Wang, Zhengping Feng
Summary: The present study compared the effects of high glucose and glucose fluctuation on apoptosis and autophagy in MC3T3-E1 osteoblasts. The results showed that high glucose and glucose fluctuation decreased cell proliferation and activated autophagy. They also induced oxidative stress, mitochondrial damage, and apoptosis, with more significant differences observed in the glucose fluctuation group. Antioxidant treatment eliminated reactive oxygen species, inhibited autophagy and apoptosis, while autophagy inhibition enhanced apoptosis in the osteoblasts.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biology
Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Gadah Albasher, Mohammed AL-Zharani, Norah M. Alhoshani, Norah S. AL-Johani, Nada H. Aljarba, Md Saquib Hasnain
Summary: Hyperglycemia, a common metabolic disorder in diabetes, causes oxidative stress, which can be alleviated by antioxidants like pyrroloquinoline quinine (PQQ). PQQ inhibits AGEs formation and reduces oxidative damage during hyperglycemia, showing potential as a therapeutic antioxidant.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yang
Summary: Nifu significantly improves cell vitality and insulin secretion function in high glucose-induced cells, inhibits oxidative stress and apoptosis factors, reduces inflammatory response, and suppresses the activation of the STAT3/SOCS3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Imen Graiet, Hiba Hamdi, Salwa Abid-Essefi, Joel Eyer
Summary: This study investigated the toxic effects and apoptotic mechanism of action of the fungicide fludioxonil on rat neural cells. The results showed that increasing concentrations of fludioxonil reduced cell viability and increased levels of reactive oxygen species and malondialdehyde. The fungicide also disrupted the cytoskeleton, caused DNA damage, depolarized mitochondria, and induced apoptosis. Pre-treatment with N-acetylcysteine restored cell viability and ROS levels.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sheelarani Karunanithi, Ruifu Liu, Yongchun Hou, Giancarlo Gonzalez, Natasha Oldford, Anne Jessica Roe, Nethrie Idipilly, Kalpana Gupta, Chandra Sekhar Amara, Satwikreddy Putluri, Grace Kyueun Lee, Juan Valentin-Goyco, Lindsay Stetson, Stephen A. Moreton, Vasanta Putluri, Shyam M. Kavuri, Yogen Saunthararajah, Marcos de Lima, Gregory P. Tochtrop, Nagireddy Putluri, David N. Wald
Summary: Inhibition of Thioredoxin Reductase (TrxR) has been identified as a promising strategy to disrupt AML metabolism, as it impairs leukemic cell growth and leads to cell death. TrxR is a major regulator of metabolism in AML cells, impacting glycolysis and the pentose phosphate pathway (PPP). The combined inhibition of TrxR and PPP enhances leukemia growth inhibition, highlighting the potential of TrxR abrogation, particularly with S-250, as an effective therapeutic approach for AML.
Article
Multidisciplinary Sciences
M. C. Madsen, F. Podieh, M. C. Overboom, A. Thijs, M. den Heijer, P. L. Hordijk
Summary: This study investigates the mechanisms underlying the effects of iron on the barrier function of human endothelium. The experimental results suggest that exposure to iron leads to endothelial cell elongation, upregulation of stress-induced proteins, and a dose-dependent drop in endothelial integrity. Reactive oxygen species (ROS) production and the role of low-grade inflammation were also investigated. The findings indicate that iron-induced damage to the vascular endothelium could contribute to increased cardiovascular risk.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zhongyuan Tang, Zonghui Zhang, Jiaqi Wang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang, Qiying Yao
Summary: Phosphocreatine (PCr) can suppress H2O2-induced apoptosis in endothelial cells and reduce hyperlipidemia by inhibiting ROS generation and modulating the dysfunctional mitochondrial system, which might be an effective new therapeutic strategy to prevent atherosclerosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Handan Bardak, Abduelhadi Cihangir Uguz, Yavuz Bardak, Javier Rocha-Pimienta, Jonathan Delgado-Adamez, Javier Espino
Summary: Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) that can cause severe visual loss. This study investigated the protective effects of selenium (Se) on retinal pigment epithelium (ARPE-19) and primary human retinal microvascular endothelial (ACBRI 181) cells against high glucose (HG)-induced oxidative stress and apoptotic cascade. The findings highlight the protective role of Se in mitigating oxidative stress and apoptosis in retinal cells exposed to high glucose.
Article
Medicine, Research & Experimental
Joyce Hou, Evelyn Tolbert, Mark Birkenbach, Nisanne S. Ghonem
Summary: This study demonstrates that treprostinil has a significant hepatoprotective effect during renal ischemia-reperfusion injury, improving liver function, antioxidant levels, suppressing inflammation, and alleviating apoptotic injury, indicating its therapeutic potential in reducing hepatic injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Applied
SeonJu Park, Nguyen Xuan Nhiem, Jae-Hyoung Song, Mira Oh, Kil-Nam Kim, Hyun-Jeong Ko, Seung Hyun Kim
Summary: Three new monoterpenoid glycosides and one new flavanol, along with known compounds, were isolated from the twig of Hamamelis japonica Sieb. et Zucc. The antiviral activities of all isolated compounds were tested, and (-)-epigallocatechin 3-O-gallate showed consistent and effective antiviral activities against EV71 and PR8 infections.
NATURAL PRODUCT RESEARCH
(2023)
Article
Physics, Multidisciplinary
Hyeon-Jong Park, Hye-Won Ko, Gyungchoon Go, Jung Hyun Oh, Kyoung-Whan Kim, Kyung-Jin Lee
Summary: In this study, we theoretically demonstrate the spin swapping effect in centrosymmetric ferromagnets, which is mediated by an orbital degree of freedom and does not require inversion asymmetry or impurity spin-orbit scattering. Our research emphasizes the important role of the orbital degree of freedom in describing spin-orbit-coupled transport in centrosymmetric materials.
PHYSICAL REVIEW LETTERS
(2022)
Article
Physics, Applied
Kwangsu Kim, Hee Young Kwon, Tae-Eon Park, Sanghoon Kim, Kyoung-Whan Kim
Summary: This paper investigates the anisotropic conductivity and magnetoresistance of two-dimensional materials, and proposes time dynamics simulation models. The results show that the total resistance can be changed depending on time and voltage.
JOURNAL OF THE KOREAN MAGNETICS SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Moojune Song, Mujin You, Seungmo Yang, Tae-Seong Ju, Kyoung-Woong Moon, Chanyong Hwang, Kyoung-Whan Kim, Albert Min Gyu Park, Kab-Jin Kim
Summary: The scaling law explains the universality in nature, and it is found in this study that the dynamics of weakly driven magnetic skyrmions are different from that of the magnetic domain wall, which is caused by a general principle beyond the topological charge.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Medicinal
Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Eun-A Kim, Junseong Kim, Kyungsook Jung, Kil-Nam Kim, Soo-Jin Heo, Ginnae Ahn
Summary: This study evaluates the protective effect of 3-bromo-4,5-dihydroxybenzaldehyde (BDB) isolated from Polysiphonia morrowii on inflammation and skin barrier deterioration in TNF-alpha/IFN-gamma-stimulated HaCaT keratinocytes. The findings reveal that BDB decreases ROS production and inflammatory cytokine expression, while increasing cell viability and skin hydration protein production. This suggests that BDB has the ability to protect against inflammation and skin barrier deterioration.
Article
Biochemistry & Molecular Biology
Seo-Young Kim, Sung-Pil Kwon, SeonJu Park, Su-Hyeon Cho, Youngse Oh, Seung Hyun Kim, Yoon Ho Park, Hyun Suk Jung, Deug-chan Lee, Hoibin Jeong, Kil-Nam Kim
Summary: Pinoresinol and vanillic acid stimulate muscle cell proliferation by activating the Akt/mTOR signaling pathway and interacting with IGF-1R.
Article
Microbiology
Hae-Won Lee, So-Ra Yoon, Yun-Mi Dang, Ji-Hyun Yun, Hoibin Jeong, Kil-Nam Kim, Jin-Woo Bae, Ji-Hyoung Ha
Summary: This study analyzed the ultra-small microbiome (USM) in fermented vegetables, specifically in kimchi, revealing differences and characteristics compared to the normal microbiome (NM). The study provided important insights into the relationship between the potential metabolic activities of the USM of kimchi and the NM.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Su-Hyeon Cho, Hoibin Jeong, SeonJu Park, Hyun-Tak Shin, Hyung-Min Lee, Kil-Nam Kim
Summary: The study demonstrated the inhibitory effects of E. koreensis Nakai root extract (EKRE) on inflammatory responses both in vitro and in vivo. The extract effectively reduced the production of nitric oxide, interleukin-6, and inducible nitric oxide synthase in cells. It also suppressed the activation of nuclear factor kappa-B and mitogen-activated protein kinase. In a mouse model, EKRE significantly inhibited carrageenan-induced paw edema.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Seungyun Han, Hyun-Woo Lee, Kyoung-Whan Kim
Summary: In this work, the authors investigate the microscopic origins and strength of orbital textures, which are k-dependent orbital states. They derive the orbital texture Hamiltonians from microscopic tight-binding models and reveal two microscopic mechanisms for the hybridization of orbital states. By considering the orbital hybridization, they not only reproduce the orbital Hamiltonian obtained by symmetry analysis but also discover previously unreported orbital textures. These orbital Hamiltonians are valuable for analyzing orbital physics and designing materials for spin-orbitronic applications.
CURRENT APPLIED PHYSICS
(2023)
Article
Physics, Multidisciplinary
Dongwook Go, Daegeun Jo, Kyoung-Whan Kim, Soogil Lee, Min-Gu Kang, Byong-Guk Park, Stefan Bluegel, Hyun-Woo Lee, Yuriy Mokrousov
Summary: Contrary to the common assumption, the orbital response in ferromagnets can exhibit remarkable long-ranged behavior, even in the presence of strong crystal field potential and orbital quenching. By studying a bilayer structure composed of a nonmagnet and a ferromagnet, it is found that induced orbital angular momentum can extend far beyond the spin dephasing length, even when an external electric field is applied only on the nonmagnet. This behavior is attributed to nearly degenerate orbital characters imposed by crystal symmetry, which form hotspots for the intrinsic orbital response. The findings suggest the potential use of long-range orbital response in orbitronic device applications.
PHYSICAL REVIEW LETTERS
(2023)
Article
Multidisciplinary Sciences
Jeong-Mok Kim, Seok-Jong Kim, Min-Gu Kang, Jong-Guk Choi, Soogil Lee, Jaehyeon Park, Cao Van Phuoc, Kyoung-Whan Kim, Kab-Jin Kim, Jong-Ryul Jeong, Kyung-Jin Lee, Byong-Guk Park
Summary: The Spin Seebeck effect (SSE) refers to the generation of electric voltage perpendicular to a temperature gradient using a magnon current. SSE has the potential for efficient thermoelectric devices because of its transverse geometry which simplifies the device structure for utilizing waste heat. However, SSE has low conversion efficiency that needs improvement for widespread application. In this study, we demonstrate a substantial enhancement of SSE by oxidizing a ferromagnet in normal metal/ferromagnet/oxide structures. The enhancement is attributed to the reduced exchange interaction in the oxidized region, which increases the temperature difference between magnons in the ferromagnet and electrons in the normal metal, or the gradient of magnon chemical potential in the ferromagnet. This result provides a promising method for improving SSE efficiency and invigorating research on thermoelectric conversion.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Woo Seung Ham, Thi Huynh Ho, Yoichi Shiota, Tatsuya Iino, Fuyuki Ando, Tetsuya Ikebuchi, Yoshinori Kotani, Tetsuya Nakamura, Daisuke Kan, Yuichi Shimakawa, Takahiro Moriyma, Eunji Im, Nyun-Jong Lee, Kyoung-Whan Kim, Soon Cheol Hong, Sonny H. H. Rhim, Teruo Ono, Sanghoon Kim
Summary: Spin current, converted from charge current via spin Hall or Rashba effects, can transfer its angular momentum to local moments in a ferromagnetic layer. A high charge-to-spin conversion efficiency is required for developing future memory or logic devices, and here it is demonstrated in an artificial superlattice without centrosymmetry. The observed field-like torque efficiency in the [Pt/Co/W] superlattice with sub-nm scale thickness is about 0.6 when the W thickness becomes 0.6 nm, which is significantly higher than other metallic heterostructures.
Article
Engineering, Electrical & Electronic
Ki Hyuk Han, Youn Ho Park, Jeong Ung Ahn, Seong Been Kim, Kyoung-Whan Kim, Tae-Eon Park, OukJae Lee, Byoung-Chul Min, Hyun Cheol Koo
Summary: Sputtered Bi2Se3 shows promise as a topological insulator for spintronic devices due to its high spin polarization and scalability. In a Bi2Se3/Ni81Fe19 device, we observe electric field control of spin-orbit torque using second-harmonic measurements. The gate voltage modulates the Fermi level and channel types, and the damping-like torque is modulated by the gate electric field near the Dirac point. This work quantitatively evaluates spin-orbit torques and demonstrates gate-controlled damping-like torque in a sputtered topological insulator/ferromagnet bilayer.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Entomology
Chol-Nam Yun, Il-Song Maeng, Son-Hui Yang, Un-Jo Hwang, Kil-Nam Kim, Kyong-Chol Kim, Kum-Chol Ho, Chung -Song Ri, Hyon-Son Yang, Song-Hun Jang
Summary: The study aimed to evaluate the phototactic behavior responses of diamondback moths (P. xylostella) to different wavelengths and photon flux densities of LED lights under laboratory and field conditions. The results showed that the moths exhibited the highest phototactic behavior responses to UV (380 nm) LED light under certain intensity conditions. The findings from the laboratory and field experiments were consistent, indicating the high sensitivity of P. xylostella moths to 380 nm LED light. The study suggests the potential use of a 380 nm LED light trap for monitoring and controlling diamondback moths.
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Eun-Sang Park, Dong-Kyu Lee, Fei Xue, Byoung-Chul Min, Hyun Cheol Koo, Paul M. Haney, Kyoung-Whan Kim, Kyung-Jin Lee
Summary: The symmetry of normal metal/ferromagnet bilayers allows spin-orbit torques (SOTs) to have two distinct angular dependences on the magnetization direction. The most studied forms of SOT are the lowest-order SOT, which consist of fieldlike and dampinglike torques. There are also higher-order SOT forms that have different spin polarization and an additional factor of magnetization direction dependence. This study measures both the lowest-order and higher-order angular dependences of SOTs in three types of bilayers and finds that the higher-order SOT is dominant for one type of bilayer while negligible for the others. Macrospin simulations show that higher-order SOT can significantly affect magnetization dynamics, which aligns with SOT-induced switching experiments.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.