Article
Oncology
Pierluigi Bonomo, Sharon Elad, Tomoko Kataoka, Paolo Bossi
Summary: The outbreak of COVID-19 significantly impacted the approach of healthcare professionals to cancer patients worldwide, leading to challenges in managing oral mucositis. Insights from the pandemic-induced restructuring of supportive care measures have sparked discussions on new models for addressing acute side effects.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Islam S. Bakr, Azza M. Zaki, Riham M. El-Moslemany, Rasha O. Elsaka
Summary: The clinical trial evaluated the efficacy of topical oral vitamin D gel in preventing radiation-induced oral mucositis, which showed that vitamin D has a beneficial effect in lowering oral mucositis development and reducing pain during radiation therapy.
Article
Oncology
Vahid Ramezani, Shiva Ghadirian, Masoud Shabani, Mohammad Ali Boroumand, Reza Daneshvar, Fatemeh Saghafi
Summary: This study evaluated the safety and efficacy of curcumin mouthwash and curcumin-nanocapsule in the treatment of radiation-induced oral mucositis (ROM). The results showed that both oral and topical application of curcumin could effectively reduce the symptoms and pain associated with ROM, with good safety profiles.
Article
Biochemistry & Molecular Biology
Ariane Venzon Naia Sardo, Maira Franco Andrade, Anaeliza Figueiredo, Flavia Cristina Perillo Rosin, Luciana Correa, Denise Maria Zezell
Summary: This study evaluated the effects of photobimodulation with red and infrared wavelengths on radio-induced oral mucositis wounds. The results show that photobiomodulation can improve the epithelial maturity of the wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Alessandro Villa, Stephen T. T. Sonis
Summary: Oral mucositis (OM) is a common and damaging side effect of head and neck radiation therapy that may affect patients' adherence to treatment. There has been increasing interest in the development of effective interventions for OM due to the unmet clinical need, recent clinical trial successes, and commercial potential. This review focuses on drugs that have recently been assessed in clinical trials and those that are still under clinical study for the prevention or treatment of radiation-associated OM.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Oncology
Soheila Manifar, Maryam Koopaie, Zahra Mofazal Jahromi, Sajad Kolahdooz
Summary: The study compared the effects of synbiotic mouthwash with normal saline mouthwash on the prevention and control of radiotherapy-induced oral mucositis in oral cancer patients. The results showed that synbiotic mouthwash significantly reduced the severity of oral mucositis and decreased the incidence of severe oral mucositis.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Multidisciplinary Sciences
Kanade Ito, Shiori Tokura, Itsuki Takazawa, Naomi Yoshida, Tohko Nakanishi, Kikue Akiyama, Yuki Onuma, Toshiko Adachi, Hiroyuki Harada, Hitomi Nojima, Masahiko Miura, Ryoichi Yoshimura, Yuji Kabasawa
Summary: This retrospective analysis found that Episil (R) can effectively relieve pain in oral mucositis (OM) caused by radiotherapy or chemoradiotherapy in head and neck cancer patients. However, medical professionals need to pay careful attention to each patient.
Review
Chemistry, Medicinal
Juliana Borges de Lima Dantas, Tila Fortuna Costa Freire, Ana Carla Barletta Sanches, Erielma Lomba Dias Juliao, Alena Ribeiro Alves Peixoto Medrado, Gabriela Botelho Martins
Summary: This study aimed to evaluate the efficacy of topical chamomile in preventing and treating oral mucositis (OM) in cancer patients. The systematic review found that topical chamomile was effective in preventing and treating OM in four out of six studies. However, the study had some limitations, such as the lack of information on the minimum age of patients. Further research is needed to determine the protocols for the use of this phytotherapy in the oncology population.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Yan Wang, Jiatong Li, Haonan Zhang, Xin Zheng, Jiantao Wang, Xiaoyue Jia, Xian Peng, Qian Xie, Jing Zou, Liwei Zheng, Jiyao Li, Xuedong Zhou, Xin Xu
Summary: The study evaluated the therapeutic effect of probiotic Streptococcus salivarius K12 on radiation-induced oral mucositis (RIOM) mice and found that S. salivarius K12 could help treat oral mucositis and promote oral mucosal healing. RIOM mice exhibited dysbiosis in their oral microbiota, which could be restored by S. salivarius K12 treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Optics
Maira Franco Andrade, Ariane Venzon Naia Sardo, Carolina Benetti, Leticia Bonfante Sicchieri, Luciana Correa, Denise Maria Zezell
Summary: Photobiomodulation (PBM) is used in clinical practice for the prevention and treatment of oral mucositis (OM). The effects of red and near-infrared wavelengths on OM repair are still unclear. This study compared the clinical effect and tissue changes caused by 660 nm and 780 nm exposure in an experimental model of OM. The results showed that both wavelengths improved the repair of ionizing radiation-induced OM, but the tissue effects were more pronounced when 660 nm was used.
Article
Immunology
Chaofei Xia, Chunling Jiang, Wenyu Li, Jing Wei, Hu Hong, Jingao Li, Liu Feng, Hong Wei, Hongbo Xin, Tingtao Chen
Summary: Probiotic cocktail supplementation can reduce oral mucositis induced by chemoradiotherapy in patients with nasopharyngeal cancer by enhancing immune response and modifying gut microbiota structure.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Saba Safarzadeh, Farinaz Shirban, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Cancer therapy-induced oral mucositis is a troublesome complication after radio-chemotherapy, and factors such as age, nutritional status, tumor type, oral hygiene, treatment method, and oxygen-free radicals can affect its incidence. Herbal medicine has been suggested as a potential alternative due to its unique properties of safety, availability, and low cost, with anti-inflammatory, anti-microbial, and antioxidative activities being essential for its palliative effects on oral mucositis.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yu-Cheng Liu, Chia-Rong Wu, Tsai-Wei Huang
Summary: This meta-analysis demonstrates the effectiveness of probiotics in preventing and mitigating cancer therapy-induced oral mucositis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Wallacy Watson Pereira Melo, Walessa Alana Braganca Aragao, Daiane Claydes Baia-da-Silva, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Renata Duarte de Souza-Rodrigues
Summary: This review article analyzed the most cited articles on the association of photobiomodulation with oral mucositis and the evolution of clinical protocols, finding that InGaAlP diode laser was commonly used and irradiated anatomical points included cheek mucosa, lips, tongue, and mouth bottom.
Article
Engineering, Biomedical
Roberta Mariano de Carvalho e Silva, Fausto Medeiros Mendes, Giovanna Rosa Degasperi, Sergio Luiz Pinheiro
Summary: This study evaluated the applicability of photobiomodulation therapy (PBM-T) in managing xerostomia and oral mucositis (OM) in patients with head and neck squamous cell carcinoma. The results showed that PBM-T significantly improved the quality of life (QoL) and reduced the severity of xerostomia symptoms. Additionally, PBM-T was effective in reducing the occurrence of OM lesions. There was no significant difference between the groups in terms of dental health indicators. Overall, PBM-T showed promise in improving the QoL of patients with head and neck cancer undergoing radiotherapy.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Oncology
Charlotte Le Roy, Cecile Le Pechoux, Claire Alapetite, Ratislav Bahleda, Carine Ngo, Charles Honore, Matthieu Faron, Axel Le Cesne, Olivier Mir, Christine Haie-Meder, Cyrus Chargari, Antonin Levy
Summary: Non-operable scalp cutaneous angiosarcoma patients face a scarcity of effective treatments. However, curative-intent definitive sequential IMRT and plesiobrachytherapy have shown promising results in two elderly patients, providing a non-invasive therapeutic option for locally advanced presentation.
Article
Oncology
Mickael Andraud, Manon Kissel, Roger Sun, Elie Rassy, Sophie Espenel, Samir Achkar, Philippe Morice, Christine Haie-Meder, Sebastien Gouy, Cyrus Chargari
Summary: Treatment of peri-urethral gynecological tumors presents challenges, and interstitial brachytherapy combined with external radiotherapy shows high local control probability as a conservative treatment option. This treatment strategy aims to spare patients from surgery-related morbidity while effectively managing the tumors.
Meeting Abstract
Oncology
M. Tagliamento, D. Vasseur, A. Bayle, M. Aldea, A. Gazzah, C. Nicotra, A. Hollebecque, D. Planchard, M. Frelaut, A. Botticella, A. Levy, L. Lacroix, C. Marzac, J. B. Micol, S. Ponce, E. Rouleau, A. Italiano, B. Besse
ANNALS OF ONCOLOGY
(2022)
Letter
Oncology
C. Ngo, T. Grinda, A. Boileve, A. Levy, C. Le Pechoux, L. Haddag, A. Valent, T. Lazure, S. Briand, C. Honore, M. Faron, O. Mir, R. Bahleda, B. Verret, A. Le Cesne
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Cyrus Chargari, Christine Haie-Meder, Sophie Espenel, Max-Adrien Garcia, Myriam Ben-Arush, Stephanie Bolle, Anna Borjesson, Maja Cesen, Rita Costa Lago, Anne-Sophie Defachelles, Barbara De Moerloose, Christine Devalck, Pernille Edslev, Nuno Jorge Farinha, Nadine Francotte, Heidi Glosli, Sebastien Gouy, Gabriela Guillen Burrieza, Sylvie Helfre, Sabine Irtan, Antonis Kattamis, Ana Lacerda, Antonin Levy, Lisa Lyngsie Hjalgrim, Ludovic Mansuy, Eric Mascard, Salma Moalla, Daniel Orbach, Cormac Owens, Pascale Philippe-Chomette, Barry Pizer, Claire Pluchart, Marleen Renard, Anne Gro Wesenberg Rognlien, Angelique Rome, Sabine Sarnacki, Akmal Safwat, Amalia Schiavetti, Jill Serre, Cecile Verite, Nicolas Von der Weid, Mariusz Wysocki, Dominique Valteay-Couanet, Eric Deutsch, Veronique Minard-Colin, Helene Martelli, Florent Guerin
Summary: This retrospective study demonstrates the feasibility and effectiveness of an international multi-center cooperation model in radiation therapy for rare pediatric cancers. Despite challenges, this cooperation model achieves a high rate of local control and an acceptable rate of late severe complications.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
E. F. Nassif, J-Y Blay, C. Massard, A. Dufresne, M. Brahmi, P. Cassier, I Ray-Coquard, P. Pautier, A. Leary, M-P Sunyach, R. Bahleda, A. Levy, C. Le Pechoux, C. Honore, O. Mir, A. Le Cesne
Summary: This study retrospectively analyzed prognostic factors for progression-free survival (PFS) in patients with advanced soft-tissue sarcomas participating in early phase trials. The study found that myxoid liposarcoma, ≥2 prior lines of treatment, liver metastasis, and RMH score >2 were independent prognostic factors for shorter PFS, while leiomyosarcoma, molecular screening, and histology-driven screening were associated with improved PFS.
Article
Oncology
Carine Ngo, Benjamin Verret, Julien Vibert, Sophie Cotteret, Antonin Levy, Cecile Le Pechoux, Leila Haddag-Miliani, Charles Honore, Matthieu Faron, Fabien Quinquis, Axel Le Cesne, Jean-Yves Scoazec, Gaelle Pierron
Summary: This study reports a case of calf EMC in a 34-year-old male and identifies a novel fusion transcript LSM14A::NR4A3, expanding the molecular spectrum of EMC.
GENES CHROMOSOMES & CANCER
(2023)
Article
Oncology
Sarah Watson, Benjamin Verret, Stanislas Ropert, Julien Adam, Rastislav Bahleda, Sylvain Briand, Andrea Cavalcanti, Ali N. Chamseddine, Charles Court, Elie Fadel, Matthieu Faron, Leila Haddag-Miliani, Clemence Henon, Cecile Le Pechoux, Antonin Levy, Olaf Mercier, Carine Ngo, Charles Honore, Axel Le Cesne, Olivier Mir
Summary: The activity of single-agent gemcitabine in advanced angiosarcoma was evaluated in this study. The results showed that gemcitabine had clinically meaningful activity, especially in cardiac angiosarcoma and patients who had received prior treatments.
Article
Oncology
Adrien Rousseau, Marco Tagliamento, Edouard Auclin, Mihaela Aldea, Maxime Frelaut, Antonin Levy, Jose C. Benitez, Charles Naltet, Pernelle Lavaud, Angela Botticella, Miruna Grecea, Nathalie Chaput, Fabrice Barlesi, David Planchard, Benjamin Besse
Summary: This study aimed to investigate the impact of the time-of-day infusion of immune checkpoint inhibitors (ICI) on the survival of patients with advanced non-small cell lung cancer (NSCLC). The results showed that patients who received at least 20% of ICI infusions after 16:30h had a significantly shorter overall survival and slightly shorter progression-free survival. However, the total number of ICI infusions and underlying prognostic characteristics may confound the results.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Sheila Terwisscha van Scheltinga, Timothy Rogers, Naima Smeulders, Federica deCorti, Florent Guerin, Ross Craigie, Gabriela Guillen Burrieza, Ludi Smeele, Marinka Hol, Rick van Rijn, Joerg Fuchs, Guido Seitz, Andreas Schmidt, Beate Timmermann, Per-Ulf Tunn, Cyrus Chargari, Raquel Davila Fajardo, Olga Slater, Jenny Gains, Hans Merks
Summary: This review discusses the developments in staging and local treatment strategies for specific sites of rhabdomyosarcoma tumors, including head and neck, chest/trunk, bladder-prostate, female genito-urinary, perianal, and extremity sites. It also focuses on the treatment strategies for very young patients, as well as those with metastatic or relapsed disease. Specific surgical techniques such as whole limb perfusion, HIPEC, and fluorescence guided surgery are also addressed. The goal of these innovations is to improve loco-regional control of the disease while minimizing treatment morbidity.
Article
Oncology
Chad G. Rusthoven, Alyse W. Staley, Dexiang Gao, Shoji Yomo, Denise Bernhardt, Narine Wandrey, Rami El Shafie, Anna Kraemer, Oscar Padilla, Veronica Chiang, Andrew M. Faramand, Joshua D. Palmer, Brad E. Zacharia, Rodney E. Wegner, Jona A. Hattangadi-Gluth, Antonin Levy, Kenneth Bernstein, David Mathieu, Daniel N. Cagney, Michael D. Chan, Inga S. Grills, Steve Braunstein, Cheng-Chia Lee, Jason P. Sheehan, Christien Kluwe, Samir Patel, Lia M. Halasz, Nicolaus Andratschke, Christopher P. Deibert, Vivek Verma, Daniel M. Trifiletti, Christopher P. Cifarelli, Juergen Debus, Stephanie E. Combs, Yasunori Sato, Yoshinori Higuchi, Kyoko Aoyagi, Paul D. Brown, Vida Alami, Ajay Niranjan, L. Dade Lunsford, Douglas Kondziolka, D. Ross Camidge, Brian D. Kavanagh, Tyler P. Robin, Toru Serizawa, Masaaki Yamamoto
Summary: By comparing patients with small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), this study found that SCLC patients had shorter overall survival (OS) after stereotactic radiosurgery (SRS), but the central nervous system (CNS) progression was similar in patients matched on baseline factors. There were no significant differences in neurological mortality, number of lesions at CNS progression, or leptomeningeal progression between SCLC and NSCLC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M. Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
Summary: In order to address the evaluation issue of radiotherapy innovations, the HERO project of ESTRO has initiated the development of a radiotherapy-specific value-based framework. A systematic literature search revealed no widely accepted definition or classification system for radiotherapy innovations. However, the unique properties of radiotherapy interventions can be used to categorize innovations in radiation oncology, but clear terminology denoting radiotherapy-specific characteristics is still needed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Respiratory System
Jean Baptiste Menager, Olaf Mercier, Antonin Levy, Angela Botticella, Pauline Pradere, Dominique Fabre, Justin Issard, Charles Naltet, David Planchard, Fabrice Barles, Vincent De Montpreville, Cecile Le Pechoux, Benjamin Besse, Elie Fadel
Summary: This study retrospectively evaluated the outcomes and risk factors for complications and death in patients who underwent extended surgery to remove thymic malignancies. The study found that extended resection targeting complete resection provided good outcomes in patients with locally advanced thymic malignancies at an expert center. However, the risk/benefit ratio of surgery should be carefully assessed in elderly patients or patients with myasthenia gravis.
RESPIRATORY MEDICINE AND RESEARCH
(2023)
Article
Oncology
Antonin Levy, Jonathan Khalifa, Etienne Martin, Angela Botticella, Clement Quevrin, Pernelle Lavaud, Mihaela Aldea, Benjamin Besse, David Planchard, Fabrice Barlesi, Eric Deutsch, Carole Massabeau, Jerome Doyen, Cecile Le Pechoux
Summary: This study evaluated the outcomes of SBRT in patients with uncommon oligoprogressive/oligorecurrent SCLC. The results showed excellent local control and rare long-term response after SBRT.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)