Article
Gastroenterology & Hepatology
Jie Hong, Fangfang Guo, Shi-Yuan Lu, Chaoqin Shen, Dan Ma, Xinyu Zhang, Yile Xie, Tingting Yan, TaChung Yu, Tiantian Sun, Yun Qian, Ming Zhong, Jinxian Chen, Yanshen Peng, Cheng Wang, Xiang Zhou, Jianjun Liu, Qiang Liu, Xiong Ma, Ying-Xuan Chen, Haoyan Chen, Jing-Yuan Fang
Summary: The study revealed a positive correlation between Fusobacterium nucleatum and high glucose metabolism in patients with colorectal cancer (CRC), suggesting a potential role of gut microbiota in CRC development. Mechanistically, Fusobacterium nucleatum activated the lncRNA ENO1-IT1 pathway to regulate CRC cell glucose metabolism and biological functions. Targeting the ENO1 pathway may have therapeutic implications for CRC patients with elevated Fusobacterium nucleatum levels.
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Yun Wei Shermane Lim, Xiaoqiang Xiang, Manoj Garg, Minh T. N. Le, Andrea Li-Ann Wong, Lingzhi Wang, Boon-Cher Goh
Summary: H19 long non-coding RNA has dual roles in cancer, acting as both an oncogene and a suppressor gene in tumor development. It plays a crucial role in cancer therapy through various mechanisms, including its applications in recombinant vectors, chemoresistance, epigenetic regulation, alteration of tumor microenvironment, and cancer immunotherapy, as well as its relationship with the tumor suppressor gene p53.
Review
Medicine, Research & Experimental
Shivam Chowdhary, Rahul Deka, Kingshuk Panda, Rohit Kumar, Abhishikt David Solomon, Jimli Das, Supriya Kanoujiya, Ashish Kumar Gupta, Somya Sinha, Janne Ruokolainen, Kavindra Kumar Kesari, Piyush Kumar Gupta
Summary: Human viral oncogenesis is a complex phenomenon that contributes significantly to the global cancer burden. Recent findings have uncovered cellular and molecular pathways involved in the development and initiation of malignancy during viral infections. Antiviral treatment has emerged as a strategy to eliminate viral infections and prevent oncogenesis. Exploring the molecular pathogenesis of various oncogenic viruses and developing potent antiviral therapies could enhance the eradication of infected malignant cells while sparing normal ones. This review discusses the advancements in natural and synthetic antivirals and highlights the challenges and future prospects of using antivirals in viral oncogenesis.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Irina V. Pronina, Leonid A. Uroshlev, Alexey A. Moskovtsev, Danila M. Zaichenko, Elena A. Filippova, Marina V. Fridman, Alexey M. Burdennyy, Vitaly I. Loginov, Tatiana P. Kazubskaya, Nikolay E. Kushlinskii, Alexey A. Dmitriev, Eleonora A. Braga, Olga I. Brovkina
Summary: This study aimed to identify lncRNA-miRNA-mRNA competing triplets that promote ovarian tumorigenesis. Through analysis of tumor samples and experimental validation, multiple RNA triplets related to ovarian cancer were identified. Some triplets showed direct binding sites between lncRNA, mRNA, and miRNA. Transfection of miRNA into cells confirmed novel connections between miRNA and OC-related genes. These findings provide potential biomarkers for early detection of metastasis.
Article
Cell Biology
Shi Li, Banzhan Ruan, Zhi Wang, Jianling Xia, Qi Lin, Ruoting Xu, Hua Zhu, Zhixian Yu
Summary: Glucose dysregulation inhibits autophagy and promotes cancer development in bladder cancer. Patients with Type 2 diabetes and bladder cancer have a poorer tumor grade and stage. The expression of YAP1, TAZ, and AMPK is negatively regulated under high glucose conditions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiahui Fan, Huaping Li, Rong Xie, Xudong Zhang, Xiang Nie, Xiaolu Shi, Jiabing Zhan, Zhongwei Yin, Yanru Zhao, Beibei Dai, Shuai Yuan, Zheng Wen, Chen Chen, Dao Wen Wang
Summary: This study aimed to elucidate the role of lncRNA in dilated cardiomyopathy (DCM) and heart failure, with a focus on the ZNF593-AS molecule. Through a series of experiments and observations, the research demonstrated the critical function of ZNF593-AS in improving cardiac function in DCM, potentially offering a new avenue for therapeutic interventions in the future.
CIRCULATION RESEARCH
(2021)
Review
Oncology
Jiazhou Ye, Xiaomin She, Ziyu Liu, Ziqin He, Xing Gao, Lu Lu, Rong Liang, Yan Lin
Summary: EIF4A3 plays a crucial role in post-transcriptional gene regulation and maintains the expression of important proteins, but its overexpression is associated with tumorigenesis in various cancers. Further research is needed to elucidate its functions, mechanisms, and potential clinical applications, providing new insights and opportunities for cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carlotta Liberale, Davide Soloperto, Alessandro Marchioni, Daniele Monzani, Luca Sacchetto
Summary: Laryngeal cancer, a common tumor in the upper aero-digestive tract, has garnered significant interest in understanding its biological mechanisms. The development of laryngeal squamous cell carcinoma (LSCC) follows a multistep process, with various risk factors involved. Genetic alterations, including inactivation of tumor suppressor genes and activation of proto-oncogenes through mechanisms like mutations and amplification, play a crucial role. Additionally, epigenetic modifications driven by miRNAs have been shown to contribute to LSCC development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
News Item
Multidisciplinary Sciences
Jeanne Erdmann
Summary: Faecal transplants have been effective in overcoming resistance to immunotherapies, leading to numerous trials investigating the link between cancer and the microbiome.
Article
Immunology
Wenbin Liu, Yang Deng, Zishuai Li, Yifan Chen, Xiaoqiong Zhu, Xiaojie Tan, Guangwen Cao
Summary: Chronic inflammation plays a key role in cancer development by interacting with genetic predispositions, environmental exposures, and inflammation-related carcinogenic factors. Interventions that reduce inflammation levels, such as exercising and anti-inflammatory medications, can lower the risk of cancer occurrence and recurrence. The Cancer Evo-Dev theory helps understand how inflammation promotes cancer development and provides a foundation for effective prophylaxis and targeted therapy of various cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yuhao Wang, Aijun Shan, Zhiwei Zhou, Wenpeng Li, Lin Xie, Bo Du, Bingxi Lei
Summary: A new lncRNA TCONS_00004099 was discovered to be highly expressed in glioma tissues and cells, promoting malignant behaviors through the miRNA TCONS_00004099, including proliferation, metastasis, and anti-apoptosis. The downstream target of lncRNA TCONS_00004099 was identified as PTPRF, suggesting a potential therapeutic target for gliomas.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Leila Yousefi, Hamid Owaysee Osquee, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Tahereh Pirzadeh, Javid Sadeghi, Fatemeh Hemmati, Bahman Yousefi, Seyyed Yaghoub Moaddab, Mehdi Yousefi, Masoud Shirmohammadi, Mohammad Hossein Somi, Khudaverdi Ganbarov, Hossein Samadi Kafil
Summary: Helicobacter pylori infection is the most common cause of gastric cancer, while long noncoding RNAs play significant roles in gastric cancer and may serve as therapeutic targets. Researchers will investigate the risk of gastric cancer in a population with high levels of both lncRNAs and H. pylori infection.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Tadeusz J. J. Kaczynski, Nadine J. J. Husami, Elizabeth D. D. Au, Michael H. H. Farkas
Summary: This passage discusses the role of TNFRSF10A gene and the adjacent AC100861.1 long noncoding RNA (lncRNA) in cell apoptosis, necroptosis, and inflammatory pathways. AC100861.1 may have a separate function in regulating necroptotic and inflammatory signaling pathways, which is distinct from changes in TNFRSF10A expression.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B. Harley, Bahram Namjou, Kenneth M. Kaufman, Leah C. Kottyan, Matthew T. Weirauch, Guojun Hou, Nan Shen
Summary: This study focuses on the functional effects of genetic loci associated with autoimmune disease, specifically investigating the dysregulation of IRF8 expression by lupus risk variants. By combining genetic, epigenomic, and CRISPR activation approaches, the authors identify a cell-type-specific enhancer for IRF8 and elucidate the molecular mechanisms underlying its dysregulation mediated by rs2280381. This integrative strategy provides insights into the regulation of critical genes in autoimmune diseases.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
Mengjuan Wu, Yimei Liu, He Zhang, Meiling Lian, Juan Chen, Haiyan Jiang, Ying Xu, Ge Shan, Shengzhou Wu
EXPERIMENTAL EYE RESEARCH
(2019)
Letter
Cell Biology
Ruirui Jia, Mei-Sheng Xiao, Zhengguo Li, Ge Shan, Chuan Huang
Article
Multidisciplinary Sciences
Yafei Yin, J. Yuyang Lu, Xuechun Zhang, Wen Shao, Yanhui Xu, Pan Li, Yantao Hong, Li Cui, Ge Shan, Bin Tian, Qiangfeng Cliff Zhang, Xiaohua Shen
Article
Immunology
Huanchang Yan, Weiyun He, Liping Huang, Hao Wu, Yuanhao Liang, Qingmei Li, Jingwei Shui, Cheng Wang, Emmanuel E. Dzakah, Zhigang Han, Shixing Tang
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Microbiology
Emmanuel Enoch Dzakah, Liping Huang, Yaohua Xue, Shuai Wei, Xiaolin Wang, Hongliang Chen, Jingwei Shui, Foster Kyei, Farooq Rashid, Heping Zheng, Bing Yang, Shixing Tang
Summary: This study identified differential expression of host cell mRNAs, lncRNAs, and miRNAs at different stages of Chlamydia trachomatis development, as well as modulation of specific signaling pathways. Host genes showed varying regulation at different time points post-infection, with a significant downregulation observed in the presence of IFN-gamma. These findings suggest potential biomarkers for the diagnosis and management of the disease.
Article
Virology
Farooq Rashid, Emmanuel Enoch Dzakah, Haiying Wang, Shixing Tang
Summary: The orf8 protein of SARS-CoV-2 induces ER stress by activating ATF6 and IRE1 pathways, inhibits PERK pathway, and acts as an interferon antagonist to suppress IFN beta production, which is not influenced by the genotypes of orf8L and orf8S.
Article
Dermatology
Emmanuel Enoch Dzakah, Jiacong Zhao, Liuyan Wang, Farooq Rashid, Ru Xu, Ligang Yang, Zhengwei Wan, Liping Huang, Haiying Wang, Shuyi Chen, Wujian Ke, Foster Kyei, Kai Deng, Shixing Tang
Summary: This study found that Chlamydia trachomatis infection can increase HIV-1 infection and replication. The results indicate that CCL3L1/CCL3L3 plays a role in enhancing HIV-1 replication and production, providing a mechanism explanation for the enhanced susceptibility to HIV-1 among Chlamydia trachomatis-infected patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Chenfeng Wang, Yang Yang, Xianning Wu, Jingxin Li, Kaiyue Liu, Debao Fang, Bingyan Li, Ge Shan, Xinyu Mei, Fang Wang, Yide Mei
Summary: This study reveals a mutual repression between p53 and lncRNA E2F1 messenger RNA stabilizing factor (EMS) in tumor suppression. EMS inhibits p53 expression by disrupting the CPEB2-p53 mRNA interaction, leading to a suppression of p53 translation. EMS plays a critical role in promoting tumorigenesis through negative regulation of p53.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Liang Chen, Chuan Huang, Ge Shan
Summary: Circular RNAs (circRNAs) are covalently closed single-stranded RNAs with unique features in their biogenesis, degradation, and transport. They have diverse molecular functions, including sponging miRNAs, regulating transcription, modulating RNA-binding proteins, and even encoding proteins. Dysregulation of circRNAs is associated with various human disorders. Further research can help resolve debates and potentially lead to biomedical applications of circRNAs.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Genetics & Heredity
Bingbing Ren, Min-Xin Guan, Tianhua Zhou, Xiujun Cai, Ge Shan
Summary: Mitochondria, organelles with circular genomes, play critical roles in energy production and homeostasis maintenance in eukaryotic cells. Recent studies have identified various mitochondria-encoded noncoding RNAs (mt-ncRNAs), including novel types such as mecciRNAs and mt-dsRNAs. This review discusses the expression patterns, biogenesis, metabolism, regulatory roles, and functional mechanisms of mt-ncRNAs, highlighting their importance in cellular physiology and potential involvement in human diseases. Additionally, advancements in technologies and methodologies, as well as future perspectives and challenges in studying these noncoding RNAs and their biomedical applications, are also addressed.
TRENDS IN GENETICS
(2023)
Review
Virology
Shuyi Chen, Haiying Wang, Emmanuel Enoch Dzakah, Farooq Rashid, Jufang Wang, Shixing Tang
Summary: This article summarizes the prevalence, pathogenicity, and genetic diversity of human pegivirus-2 (HPgV-2) and discusses the possible reasons for the uniformity of its genome sequence.
Article
Public, Environmental & Occupational Health
Ningjun Ren, Yuansheng Li, Zhengwei Wan, Ruolan Wang, Wenxin Zhang, Emmanuel Enoch Dzakah, Junhui Zhang, Ailing Li, Song Fan
Summary: This study revealed a significant rise in HIV mortality among both genders in China from 1990 to 2019, especially among the elderly population. Strengthening HIV testing and health education is urgently needed to prevent HIV-related deaths.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Letter
Cell Biology
Cai-Rong Sun, Da Xu, Fengrui Yang, Zhuanghao Hou, Yuyao Luo, Chen-Yu Zhang, Ge Shan, Guangming Huang, Xuebiao Yao, Yuxing Chen, Qiong Li, Cong-Zhao Zhou
Article
Chemistry, Multidisciplinary
Jingxin Li, Xiaolin Wang, Liang Shi, Boqiang Liu, Zhiyong Sheng, Shuhui Chang, Xiujun Cai, Ge Shan
Summary: This study identifies a mammalian conserved circRNA, circLARP1B, as playing critical roles in hepatocellular carcinoma (HCC). It promotes HCC metastasis and lipid accumulation by affecting LKB1 mRNA stability and protein levels through the HNRNPD-LKB1-AMPK pathway.
Article
Biotechnology & Applied Microbiology
Shuai Wei, He Chen, Emmanuel Enoch Dzakah, Bin Yu, Xiaolin Wang, Tao Fu, Jingxin Li, Lei Liu, Shucheng Fang, Weihong Liu, Ge Shan
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
