Journal
CANCER LETTERS
Volume 421, Issue -, Pages 94-102Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.02.022
Keywords
Tumour microenvironment; Long non-coding RNA; Extracellular signalling; Exosomes; Stroma
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Funding
- Cancer Research UK [S_3319, 26094, 20526] Funding Source: researchfish
- Medical Research Council [MR/R002061/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2012-26-005, ACF-2015-26-008, CL-2015-26-003] Funding Source: researchfish
- Medical Research Council [MR/R002061/1] Funding Source: Medline
- MRC [MR/R002061/1] Funding Source: UKRI
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Long non-coding RNAs (IncRNAs) are a diverse class of RNA transcripts which have limited protein coding potential. They perform a variety of cellular functions in health, but have also been implicated during malignant transformation. A further theme in recent years is the critical role of the tumour microenvironment and the dynamic interactions between cancer and stromal cells in promoting invasion and disease progression. Whereas the contribution of deregulated IncRNAs within cancer cells has received considerable attention, their significance within the tumour microenvironment is less well understood. The tumour microenvironment consists of cancer-associated stromal cells and structural extracellular components which interact with one another and with the transformed epithelium via complex extra cellular signalling pathways. LncRNAs are directly and indirectly involved in tumour/stroma cross-talk and help stimulate a permissive tumour microenvironment which is more conducive for invasive tumour growth. Furthermore, IncRNAs play key roles in determining the phenotype of cancer associated stromal cells and contribute to angiogenesis and immune evasion pathways, extracellular-matrix (ECM) turnover and the response to hypoxic stress. Here we explore the multifaceted roles of IncRNAs within the tumour microenvironment and their putative pathophysiological effects. (C) 2018 Elsevier B.V. All rights reserved.
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