Defective HLA class I antigen processing machinery in cancer

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance

(2017) Barbara Seliger et al.   OncoImmunology

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

(2016) Shuhei Ito et al.   ANNALS OF SURGICAL ONCOLOGY

The hypoxic tumor microenvironment: A driving force for breast cancer progression

(2016) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells

(2016) Sofia R. Gameiro et al.   Oncotarget

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity

(2016) John D. Martin et al.   Cold Spring Harbor Perspectives in Medicine

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

(2016) E. J. Brea et al.   Cancer Immunology Research

PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma

(2015) F. Sabbatino et al.   CLINICAL CANCER RESEARCH

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

(2015) Chien-Chung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of tapasin correlates with diminished CD8+ T-cell immunity and prognosis in colorectal cancer

(2015) Lena Sokol et al.   Journal of Translational Medicine

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients

(2015) R. M. Srivastava et al.   Cancer Immunology Research

Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models

(2015) A Covre et al.   OncoImmunology

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma

(2013) J. T. Yeung et al.   CLINICAL CANCER RESEARCH

Update on the role of ipilimumab in melanoma and first data on new combination therapies

(2013) Michele Maio et al.   CURRENT OPINION IN ONCOLOGY

Alteration of HLA-F and HLA I antigen expression in the tumor is associated with survival in patients with esophageal squamous cell carcinoma

(2012) X. Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

(2011) KIMITAKA TANAKA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer vaccines at an inflexion point: what next?

(2011) Adrian Bot et al.   Journal of Translational Medicine

Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function

(2010) A. Boni et al.   CANCER RESEARCH

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors

(2010) Isabel Maleno et al.   IMMUNOGENETICS

HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis

(2010) Bandoh   ONCOLOGY REPORTS

Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer

(2010) Rui-Qing Peng   WORLD JOURNAL OF GASTROENTEROLOGY

Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells

(2009) Andrés López-Albaitero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma

(2008) Y Mizukami et al.   BRITISH JOURNAL OF CANCER

Cancer Immunotherapy

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE