Article
Oncology
Rui Shi, Zirong Liu
Summary: RPL15 plays crucial roles in the progression and metastasis of hepatocellular carcinoma (HCC), serving as a promising candidate for targeted therapies.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Jingyi Chen, Fangxin Zhao, Hongxin Yang, Jianxun Wen, Ying Tang, Fang Wan, Xuan Zhang, Jianqiang Wu
Summary: This study reveals that Gentian violet (GV) induces ferroptosis and apoptosis, inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma (HCC). It also attenuates HCC growth in vivo. The findings demonstrate a GV-Hep27-MDM2-p53 signaling cascade that regulates ferroptosis and apoptosis, providing insights into the anti-tumor function of GV and potential therapeutic strategies for HCC treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Ju-Ha Kim, Ji Hoon Jung, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Jieon Park, Woon-Yi Park, Chi-Hoon Ahn, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim
Summary: Research has shown that UBE2M promotes the progression of liver cancer by acting as a negative regulator of p53 through binding to MDM2 and ribosomal protein L11. Depletion of UBE2M can inhibit cell proliferation and induce apoptosis.
Article
Biochemistry & Molecular Biology
Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E. Zage
Summary: USP7 inhibition is a promising therapeutic strategy for high-risk and relapsed neuroblastoma (NB) in children. Inhibiting USP7 activates the p53 pathway, induces apoptosis in NB cells, and reduces N-myc protein levels. The combination of USP7 and MDM2 inhibition shows enhanced efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaoqin Jiang, Huizhen Li, Yu Fang, Chuanliang Xu
Summary: This study found that lncRNA PVT1 promotes proliferation and drug resistance of bladder cancer cells by upregulating MDM2 expression and AURKB-mediated p53 ubiquitination.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Zhenyu You, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Peng
Summary: The study found that miR-15a expression is decreased in hepatocellular carcinoma (HCC) tissues and cells. P53 upregulates miR-15a expression to inhibit the proliferation, migration, and invasion of HCC cells, induce apoptosis, and trigger G0/G1 cell cycle arrest. OGT stabilizes EZH2 through catalyzing O-GlcNAc, which counteracts the effects of P53 and miR-15a.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Mayu Nakagawa, Shyoma Higuchi, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Ako Yokoi, Yu Ishibashi, Takashi Ito, Makoto Saegusa
Summary: The study suggests that the interaction between S100A1 and MDM2 may modulate proliferation, susceptibility to apoptosis, and migration through alterations in p53 signaling in normal endometrial cells. However, such correlations were absent in malignant endometrial cells.
Article
Oncology
Shu-Guang Su, Qiu-Li Li, Mei-Fang Zhang, Peng-Wei Zhang, Huimin Shen, Chris Zhiyi Zhang
Summary: DDX11 is upregulated in HCC and correlates with poor patient outcomes, exerting oncogenic activity via the EZH2/p21 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Nan-Nan Tian, Yan-Biao Zheng, Zhi-Peng Li, Feng-Wei Zhang, Jin-Fang Zhang
Summary: This study aimed to investigate the anti-tumor effect of Curcumol on hepatocellular carcinoma (HCC) and elucidate its underlying mechanism from the perspective of epigenetic modification. The results demonstrated that Curcumol suppressed tumor growth and metastasis via an Hotair/EZH2/histone modification regulatory axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Weihua Jin, Lufeng Yan, Jeung-Hoi Ha, Ashley J. Canning, Michael Connelly, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Jianhan Chen, Stewart N. Loh, Chunyu Wang
Summary: Epigallocatechin gallate (EGCG) in green tea induces apoptosis in cancerous cells through a direct interaction with the tumor suppressor p53, inhibiting p53 ubiquitination by its regulatory E3 ligase MDM2 and stabilizing p53 for anti-tumor activity.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Tao Chen, Fei Wang, Shupei Wei, Yingjie Nie, Xiaotao Zheng, Yu Deng, Xubin Zhu, Yuezhen Deng, Nanshan Zhong, Chengzhi Zhou
Summary: The study revealed that the FGFR/RACK1 complex regulates senescence in LSCC cells by promoting the degradation of p53 through the formation of a complex with MDM2. Inhibition of FGFR or knockdown of RACK1 induced cell senescence, while inhibitors targeting MDM2 and p53 cooperatively inhibited colony formation and metastasis of LSCC cells. This understanding could have important implications for the treatment of LSCC.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Oncology
Renyi Su, Huizhong Zhang, Lincheng Zhang, Abdul Rehman Khan, Xuanyu Zhang, Rui Wang, Chuxiao Shao, Xuyong Wei, Xiao Xu
Summary: A ceRNA regulatory network, involving PVT1/miR-1258/DUSP13 axis, was found to be significantly associated with the progression of MVI in HCC patients. This finding provides new insight into the tumor invasion mechanism in liver cancer.
Article
Oncology
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Summary: This study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therapeutically targeting EZH2 to induce cellular senescence and destroy senescent cells could be a potential treatment strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dongjuan Si, Huijuan Luo, Xiaomeng Zhang, Kundi Yang, Hongmei Wen, Wei Li, Jian Liu
Summary: Inhibition of p53-MDM2 interactions is a promising strategy for cancer treatment. The unsaturated pyrrolidone compound 4h showed good binding affinity with MDM2 and demonstrated excellent antitumor activity by inducing cell cycle arrest and apoptosis. This compound has potential as a novel antitumor agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Yuan Yin, Zhiyuan Jiang, Jiamei Fu, Yang Li, Chao Fang, Xiaonan Yin, Ye Chen, Na Chen, Junshu Li, Yanhong Ji, Xiaolan Su, Meng Qiu, Wei Huang, Bo Zhang, Hongxin Deng, Lei Dai
Summary: The study reveals the expression and function of SLC5 family members in colorectal cancer, showing that downregulation of SLC5A7 correlates with CRC staging and prognosis response. Overexpression of SLC5A7 inhibits CRC growth by promoting p53 protein expression, suggesting a potential therapeutic target for CRC.
Article
Oncology
Chong Hao, Peng-Xi Zhu, Xue Yang, Zhi-Peng Han, Jing-Hua Jiang, Chen Zong, Xu-Guang Zhang, Wen-Ting Liu, Qiu-Dong Zhao, Ting-Ting Fan, Li Zhang, Li-Xin Wei
Article
Cell Biology
J. Hou, Z-p Han, Y-y Jing, X. Yang, S-s Zhang, K. Sun, C. Hao, Y. Meng, F-h Yu, X-q Liu, Y-f Shi, M-c Wu, L. Zhang, L-x Wei
CELL DEATH & DISEASE
(2013)
Review
Biochemistry & Molecular Biology
Xue Yang, Jing Hou, Zhipeng Han, Ying Wang, Chong Hao, Lixin Wei, Yufang Shi
CELL AND BIOSCIENCE
(2013)
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Chong Hao, Zhimei Sheng, Wenhao Wang, Ruijun Feng, Yuanhang Zheng, Qinpei Xiao, Baogang Zhang
Summary: This study reveals the crucial role of tumor-associated macrophages (TAMs) and exosomes in the tumor microenvironment for breast cancer growth. Exosomal miR-148b-3p can induce M2 polarization of macrophages and promote the migration and invasion of breast cancer cells by targeting TSC2 and activating the mTORC1 signaling pathway.