Article
Multidisciplinary Sciences
Shiyu Zhang, Cheng Liu, Xuan Zou, Xiangnan Geng, Xin Zhou, XingChen Fan, Danxia Zhu, Huo Zhang, Wei Zhu
Summary: A three-miRNA panel (miR-146a-5p, miR-24-3p, and miR-93-5p) was successfully established in peripheral serum as a non-invasive biomarker for diagnosing prostate cancer. This panel showed stable diagnostic performance in large cohorts and outperformed other miRNA biomarkers in diagnosing PC.
Article
Immunology
Cheng Wang, Cuiping Zhang, Quan Fu, Nan Zhang, Meng Ding, Zhen Zhou, Xi Chen, Fengmin Zhang, Chunni Zhang, Chen-Yu Zhang, Jun-Jun Wang
Summary: This study identified three piRNAs with significantly increased levels in the serum of patients with brucellosis. The combination of these three piRNAs could serve as a novel blood-based auxiliary tool for detecting brucellosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vivek Kumar, Archana Pandey, Arisha Arora, Priyanka Gautam, Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: This study aimed to evaluate the therapeutic and diagnostic potential of microRNA (miRNA) in the management of epithelial ovarian cancer (EOC). Expression analysis and functional enrichment revealed the association of miRNA with the disease and involvement of target genes in cancer progression pathways. miRNA-205 and miRNA-34a were found to be significantly downregulated and upregulated, respectively, in EOC, and showed significant negative correlation with their target genes. The combined miRNA-target gene panel exhibited higher diagnostic value in predicting the risk of EOC.
DNA AND CELL BIOLOGY
(2023)
Article
Biology
Pattaralawan Sittiju, Parunya Chaiyawat, Dumnoensun Pruksakorn, Jeerawan Klangjorhor, Weerinrada Wongrin, Phichayut Phinyo, Rawikant Kamolphiwong, Areerak Phanphaisarn, Pimpisa Teeyakasem, Prachya Kongtawelert, Peraphan Pothacharoen
Summary: Novel or OS-specific biomarkers from GEO database show promise for developing diagnostic and tumor progression strategies. Three candidate genes, including COL5A2, ezrin, and vimentin, were identified as potential tools for OS detection and disease progression prediction. Liquid biopsy is an interesting non-invasive tool for measuring tumor material, with VIM and ezrin genes associated with EMT and metastasis in OS.
Article
Oncology
Xingchen Fan, Minmin Cao, Cheng Liu, Cheng Zhang, Chunyu Li, Wenfang Cheng, Shiyu Zhang, Huo Zhang, Wei Zhu
Summary: The study identified miR-142-3p, miR-146a-5p, and miR-151a-5p as potential biomarkers for endometrial cancer in plasma, showing diagnostic value. These miRNAs were significantly overexpressed in EC patients and the 3-miRNA signature had stable diagnostic performance superior to other biomarkers in EC diagnosis. Moreover, miR-151a-5p was found to be elevated in EC plasma exosomes.
Article
Oncology
Jing Wu, Zian Feng, Rui Wang, Ang Li, Hong Wang, Xiaodong He, Zuojun Shen
Summary: The aim of this study is to identify plasma exosomal miRNAs as noninvasive biomarkers for the early diagnosis of lung adenocarcinoma. Through next-generation sequencing and bioinformatics analysis, three candidate miRNAs have been identified, and further experimental validation suggests the potential use of these miRNAs for early diagnosis of lung adenocarcinoma.
Article
Oncology
Dao-xiong Ye, Si-si Wang, Ying Huang, Xiao-jie Wang, Pan Chi
Summary: The study revealed that USP43 is highly expressed in colorectal cancer and can promote the development of colorectal cancer by affecting cell proliferation, migration, invasion, and the expression of EMT biomarkers. Furthermore, USP43 can regulate ZEB1 degradation through the ubiquitination pathway, and stabilize the ZEB1 protein, which plays a crucial role in the function of colorectal cancer.
Article
Biotechnology & Applied Microbiology
Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo, Eun Joo Song
Summary: This study successfully optimized the conditions for extraction and qRT-PCR, improving miRNA yields while minimizing interference and loss. The research aimed to achieve reliable results by reducing contaminants and maximizing product yields for miRNA analysis in plasma samples.
Article
Oncology
Xiaoyun Hu, Qiuchen Chen, Hao Guo, Kuo Li, Boshi Fu, Yu Chen, Haishan Zhao, Minjie Wei, Yalun Li, Huizhe Wu
Summary: Elevated miR-425 and miR-576 promote colorectal cancer liver metastases (CRLM) by inhibiting PTEN-mediated cellular immune function. They were found to be closely associated with tumor deterioration, especially liver metastases, and may serve as novel biomarkers for CRLM prevention and immunotherapy, as well as upstream inhibitors of the PTEN-P53/TGF-beta function axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
T. Gurer, A. Aytekin, E. Caki, S. Gezici
Summary: miR-485-3p and miR-4728-5p expression levels were significantly downregulated in CRC tissues, with lower expression of miR-485-3p in both rectum and colon and decreased miR-4728-5p expression associated with age. Bioinformatics analysis identified TFs associated with these miRNAs, suggesting a potential role in early diagnosis and treatment of CRC. Pathway enrichment analysis highlighted the involvement of Hippo signaling pathway in the regulation of miR-485-3p.
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Article
Genetics & Heredity
Linxiang Feng, Zian Feng, Jie Hu, Jiahui Gao, Ang Li, Xiaodong He, Liu Liu, Zuojun Shen
Summary: In this study, high-throughput sequencing of miRNAs in plasma exosomes from lung adenocarcinoma patients and healthy individuals was performed. The results identified hsa-miR-4454 and hsa-miR-619-5p as potential biomarkers for the early diagnosis of lung adenocarcinoma.
FRONTIERS IN GENETICS
(2023)
Review
Medicine, Research & Experimental
Zhichao Wang, Wenjie Xie, Hongzai Guan
Summary: MicroRNAs are small non-coding RNAs that interact with their target mRNAs to degrade them or inhibit translation. Dysregulation of miRNAs is associated with various human cancers and plays a role in the development of cancer pathology. MiR-328 has been implicated in multiple human cancers and considered a key regulator. It is involved in biological processes such as cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition. This review combines basic and clinical studies to demonstrate that miR-328 promotes tumorigenesis and metastasis in human cancer and discusses its diagnostic, prognostic, and therapeutic value.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Hanna Romanowicz, Piotr Hogendorf, Alicja Majos, Adam Durczynski, Dariusz Wojtasik, Beata Smolarz
Summary: This study aimed to analyze the expression of four miRNA sequences (miR-143, miR-1, miR-210, and let-7e) and investigate their significance in the risk of developing colorectal cancer. The study revealed that miR-143 may be associated with the development of colorectal cancer.
Article
Cell Biology
Rui Mao, Fan Yang, Zheng Wang, Chenxin Xu, Qian Liu, Yanjun Liu, Tongtong Zhang
Summary: An accurate and specific signature based on immune-related genes has been developed to predict the recurrence of CRC, with the ability to predict prognosis in different patient subgroups and mutation states. High-risk patients show poorer response to chemotherapy and immunotherapy, as well as lower immune scores, and the signature serves as an independent prognostic factor in predicting the overall survival of CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haowei He, Nana Wang, Xiaoming Yi, Chaopeng Tang, Dong Wang
CELL AND BIOSCIENCE
(2017)
Article
Urology & Nephrology
Le Qu, Ze-lin Wang, Qi Chen, Yao-ming Li, Hao-wei He, James J. Hsieh, Song Xue, Zhen-jie Wu, Bing Liu, Hao Tang, Xiao-feng Xu, Feng Xu, Jie Wang, Yi Bao, An-bang Wang, Dong Wang, Xiao-ming Yi, Zhong-kui Zhou, Chang-jie Shi, Ke Zhong, Zheng-cheng Sheng, Yu-lin Zhou, Jun Jiang, Xiao-yuan Chu, Jia He, Jing-ping Ge, Zheng-yu Zhang, Wen-quan Zhou, Cheng Chen, Jian-hua Yang, Ying-hao Sun, Lin-hui Wang
Review
Medicine, General & Internal
H. He, Z. Zhang, J. Ge, W. Zhou
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2014)
Article
Multidisciplinary Sciences
Haowei He, Linhui Wang, Wenquan Zhou, Zhengyu Zhang, Longxin Wang, Song Xu, Dong Wang, Jie Dong, Chaopeng Tang, Hao Tang, Xiaoming Yi, Jingping Ge
Article
Oncology
Bowen Du, Yulin Zhou, Xiaoming Yi, Tangliang Zhao, Chaopeng Tang, Tianyi Shen, Kai Zhou, Huixian Wei, Song Xu, Jie Dong, Le Qu, Haowei He, Wenquan Zhou
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Yankang Cui, Tianyi Shen, Feng Xu, Jing Zhang, Yuhao Wang, Jiajin Wu, Hengtao Bu, Dian Fu, Bo Fang, Huichen Lv, Suchun Wang, Changjie Shi, Bianjiang Liu, Haowei He, Hao Tang, Jingping Ge
Summary: This study is the first to assess the prognostic value of immune-related ceRNA hub genes in ccRCC, and KCNN4 has been demonstrated as a key regulatory factor strongly correlated with Tregs and mast cells resting.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Tianyi Shen, Suqin Miao, Yulin Zhou, Xiaoming Yi, Song Xue, Bowen Du, Chaopeng Tang, Le Qu, Dian Fu, Ruipeng Jia, Haowei He
Summary: Exosomes derived from clear cell renal cell carcinoma cells deliver AP000439.2 to promote M2 macrophage polarization, enhancing the progression of ccRCC.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Medicine, General & Internal
H. He, C. Tang, X. Yi, W. Zhou
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2018)
