Journal
CANCER BIOLOGY & THERAPY
Volume 19, Issue 3, Pages 181-187Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2017.1415677
Keywords
Micro-RNAs; Cancer; Multidrug Resistance; Taxanes; P-glycoprotein
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Funding
- Florida State University Research Foundation
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Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of drug resistant cells is a frequent problem. One of the main contributors to the development of MDR is increased expression of multi-drug resistant protein 1 (MDR1), also known as P-glycoprotein (P-gp). P-gp is a membrane-associated efflux pump that can efficiently remove internalized taxane-base chemotherapeutics thus preventing drug accumulation and maintaining cellular viability. Consequently, investigation into the molecular mechanisms responsible for regulation of P-gp expression is necessary to facilitate treatment of MDR tumors. Using molecular and biochemical approaches, we identified that the micro-RNA, miRNA149, contributes to the development of MDR within malignant mesothelioma cells by regulating the expression of MDR1.
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