Journal
CANCER AND METASTASIS REVIEWS
Volume 37, Issue 2-3, Pages 509-518Publisher
SPRINGER
DOI: 10.1007/s10555-018-9745-x
Keywords
Lysophosphatidic acid; Lysophosphatidic acid receptor; Autotaxin; Cancer stem cells
Categories
Funding
- MRC program [NRF-2015R1A5A2009656]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF-2018R1C1B6001290, NRF-2016R1D1A1B03935769]
- National Cancer Institute of the USA [CA092160]
- Korea Health Technology R&D Project, Ministry of Health and Welfare [HI17C1635]
Ask authors/readers for more resources
Stem cells are a rare subpopulation defined by the potential to self-renew and differentiate into specific cell types. A population of stem-like cells has been reported to possess the ability of self-renewal, invasion, metastasis, and engraftment of distant tissues. This unique cell subpopulation has been designated as cancer stem cells (CSC). CSC were first identified in leukemia, and the contributions of CSC to cancer progression have been reported in many different types of cancers. The cancer stem cell hypothesis attempts to explain tumor cell heterogeneity based on the existence of stem cell-like cells within solid tumors. The elimination of CSC is challenging for most human cancer types due to their heightened genetic instability and increased drug resistance. To combat these inherent abilities of CSC, multi-pronged strategies aimed at multiple aspects of CSC biology are increasingly being recognized as essential for a cure. One of the most challenging aspects of cancer biology is overcoming the chemotherapeutic resistance in CSC. Here, we provide an overview of autotaxin (ATX), lysophosphatidic acid (LPA), and their signaling pathways in CSC. Increasing evidence supports the role of ATX and LPA in cancer progression, metastasis, and therapeutic resistance. Several studies have demonstrated the ATX-LPA axis signaling in different cancers. This lipid mediator regulatory system is a novel potential therapeutic target in CSC. In this review, we summarize the evidence linking ATX-LPA signaling to CSC and its impact on cancer progression and metastasis. We also provide evidence for the efficacy of cancer therapy involving the pharmacological inhibition of this signaling pathway.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available