Eicosanoids and HB-EGF/EGFR in cancer

Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC

(2016) Cheng-Chieh Yang et al.   ORAL ONCOLOGY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells

(2015) Yanuar Dwi Putra Limasale et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Simultaneous Inhibition of EGFR/VEGFR and Cyclooxygenase-2 Targets Stemness-Related Pathways in Colorectal Cancer Cells

(2015) Araceli Valverde et al.   PLoS One

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo

(2014) MING QIAN et al.   ONCOLOGY REPORTS

Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis

(2013) František Liška et al.   AMERICAN JOURNAL OF HYPERTENSION

TNFα-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells

(2013) M. Zhu et al.   CELL PROLIFERATION

Wnt signaling in adult intestinal stem cells and cancer

(2013) Michaela Krausova et al.   CELLULAR SIGNALLING

Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies

(2013) D. M. Shin et al.   CLINICAL CANCER RESEARCH

Aspirin and Colorectal Cancer: Back to the Future

(2013) David Tougeron et al.   CLINICAL CANCER RESEARCH

The Effect of Helicobacter pylori on Epidermal Growth Factor Receptor-Induced Signal Transduction and the Preventive Effect of Celecoxib in Gastric Cancer Cells

(2013) Jaeyeon Kim et al.   Gut and Liver

Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells

(2012) Yingting Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor

(2012) Candice M. Thomas et al.   CLINICAL SCIENCE

IL1β-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

(2012) Yingting Zhu et al.   EXPERIMENTAL CELL RESEARCH

iNOS signaling interacts with COX-2 pathway in colonic fibroblasts

(2012) Yingting Zhu et al.   EXPERIMENTAL CELL RESEARCH

Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival

(2012) Xiaoyun Liao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemoprevention in familial adenomatous polyposis

(2011) Brian Kim et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer

(2011) Johnny Kao et al.   CANCER

A Randomized Placebo-Controlled Prevention Trial of Aspirin and/or Resistant Starch in Young People with Familial Adenomatous Polyposis

(2011) J. Burn et al.   Cancer Prevention Research

Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis

(2011) Hiroko Oshima et al.   CANCER SCIENCE

Colon tumour cells increase PGE2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

(2011) H. R. Roberts et al.   CARCINOGENESIS

New Strategies in Overcoming Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer

(2011) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Effectiveness of Tyrosine Kinase Inhibitors on "Uncommon" Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non-Small Cell Lung Cancer

(2011) J.-Y. Wu et al.   CLINICAL CANCER RESEARCH

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

(2011) Katrin J. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of inflammation in cancer by eicosanoids

(2011) Emily R. Greene et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

IL-1β induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells

(2010) Ching-Yi Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

(2010) Aditya Murthy et al.   JOURNAL OF CLINICAL INVESTIGATION

The Effects of the Stromal Cell-Derived Cyclooxygenase-2 Metabolite Prostaglandin E2 on the Proliferation of Colon Cancer Cells

(2010) S.-W. Park et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

(2010) Peter M Rothwell et al.   LANCET

Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells

(2010) L Sauer et al.   ONCOGENE

Role of the Low-Affinity Leukotriene B 4 Receptor BLT2 in VEGF-Induced Angiogenesis

(2009) Geun-Young Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase

(2009) Chul-Ho Jeong et al.   CANCER RESEARCH

Aspirin Use and Survival After Diagnosis of Colorectal Cancer

(2009) Andrew T. Chan   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

(2009) Pierre Laurent-Puig et al.   JOURNAL OF CLINICAL ONCOLOGY

HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells

(2009) Kozo Nakai et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

(2009) Alexandra Szalad et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The CysLT1 Ligand Leukotriene D4 Supports  4 1- and  5 1-Mediated Adhesion and Proliferation of CD34+ Hematopoietic Progenitor Cells

(2009) A. M. Boehmler et al.   JOURNAL OF IMMUNOLOGY

Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

(2009) Andrea Sartore-Bianchi et al.   PLoS One

Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma

(2008) Ahmad Jalili et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on non-small cell lung cancer cell lines: in vitro toxicity and mechanism study

(2008) Likun Chen et al.   MEDICAL ONCOLOGY

PGE2 and LTB4 tissue levels in benign and cancerous prostates

(2008) Stéphane Larré et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Validation of HB-EGF and amphiregulin as targets for human cancer therapy

(2007) Fusanori Yotsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Celecoxib Induced Tumor Cell Radiosensitization by Inhibiting Radiation Induced Nuclear EGFR Transport and DNA-Repair: A COX-2 Independent Mechanism

(2007) Klaus H. Dittmann et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS