Article
Infectious Diseases
Baptiste Hoellinger, Charlotte Kaeuffer, Pierre Boyer, Nicolas Lefebvre, Yves Hansmann, Amandine Robert, Francois Severac, Alain Gravet, Francois Danion, Yvon Ruch, Axel Ursenbach
Summary: This study compared the use of cefepime with carbapenems for the treatment of third-generation cephalosporin-resistant ABLHE bloodstream infections. The results showed no significant difference in 30-day in-hospital mortality, infection recurrence, or treatment toxicity between the two groups. Therefore, this study supports the use of cefepime in cases with a minimal inhibitory concentration < 1 mg/l to spare carbapenems.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Muhammad Muqaddas Mustafai, Mavra Hafeez, Safa Munawar, Sakeenabi Basha, Ali A. Rabaan, Muhammad A. Halwani, Abdulsalam Alawfi, Amer Alshengeti, Mustafa A. Najim, Sara Alwarthan, Meshal K. AlFonaisan, Souad A. Almuthree, Mohammed Garout, Naveed Ahmed
Summary: Enterobacteriaceae have been classified as severely drug resistant bacteria by the World Health Organization due to their extensive production and dissemination of carbapenemases (CPs) and extended-spectrum beta-lactamases (ESBL). A hospital-based study was conducted to determine the prevalence of CP- and ESBL-producing Enterobacteriaceae and their antibiotic susceptibility profiles. The study found high rates of CP- and ESBL-producing Enterobacteriaceae, indicating a significant spread in the study area. The authors recommend implementing better infection prevention and control strategies and conducting nationwide screening to reduce the burden of highly resistant bugs.
Article
Infectious Diseases
Kelly C. Gamble, Dusten T. Rose, Julia Sapozhnikov
Summary: The study aimed to evaluate the clinical outcomes of oral step-down antibiotics compared with continued intravenous therapy in non-bacteremic urinary tract infections. The results showed no significant difference between the two treatment groups in terms of clinical failure, readmission rate, and other outcomes. However, the switch group was associated with reduced hospital length of stay and antibiotic costs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Immunology
Hiroki Namikawa, Waki Imoto, Koichi Yamada, Yoshihiro Tochino, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis identified predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) bacteremia. Previous antimicrobial therapy, neutropenia, nosocomial infection, rapidly fatal underlying disease, respiratory tract infection, Pitt bacteremia score, severe sepsis, and urinary tract infection were found to be predictors of mortality. Appropriate empirical therapy was identified as a protective factor against mortality.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Jin Ju Park, Eun-ju Jung, Jae-Young Kim, Yu Bin Seo, Jacob Lee, Younghee Jung
Summary: This study compared the 30-day mortality rates of patients receiving Ertapenem and other carbapenems for the treatment of ESBL-producing Enterobacterales bacteremia. The results showed that there was no difference in mortality rates between Ertapenem and other carbapenems, suggesting comparable efficacy. The study also found no difference in secondary outcomes such as Clostridioides diffide infection (CDI) and the emergence of multidrug-resistant Gram-negative bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Huan Zhang, Juan Xu, Qinyan Xiao, Yuhang Wang, Jin Wang, Man Zhu, Yun Cai
Summary: This meta-analysis found that beta-lactam/beta-lactamase inhibitor combinations (BLBLIs) were noninferior to carbapenems for bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), especially in definitive therapy. BLBLIs may be a valid alternative to spare the use of carbapenems.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Environmental Sciences
Lukas Bock, Lisandra Aguilar-Bultet, Adrian Egli, Manuel Battegay, Andreas Kronenberg, Roland Vogt, Carole Kaufmann, Sarah Tschudin-Sutter
Summary: Higher outdoor temperature may be associated with an increase in the incidence of ESBL-PE, independent of other potential confounding factors, such as antimicrobial consumption.
ENVIRONMENTAL RESEARCH
(2022)
Article
Immunology
Isabelle Vock, Lisandra Aguilar-Bultet, Adrian Egli, Pranita D. Tamma, Sarah Tschudin-Sutter
Summary: Majority of infections in hospitalized patients colonized with ESBL-PE are not caused by ESBL-PE. Site of infection and patient-level exposures may serve as useful predictors for nESBI,-PE infections, potentially guiding empiric treatment recommendations.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Soo Tein Ngoi, Cindy Shuan Ju Teh, Chun Wie Chong, Kartini Abdul Jabar, Shiang Chiet Tan, Lean Huat Yu, Kin Chong Leong, Loong Hua Tee, Sazaly AbuBakar
Summary: The prevalence of ESBL-producing Enterobacteriaceae has impacted the efficacy of beta-lactam antibiotics in treating UTIs. This study showed high rates of resistance to various beta-lactam antibiotics in ESBL-producing E. coli and K. pneumoniae isolated from UTIs, with carbapenems remaining the most effective treatment option. Flomoxef may serve as a potential alternative to carbapenems for treating UTIs caused by ESBL-producers in Malaysia.
Article
Microbiology
Dagninet Alelign, Aschalew Kidanewold
Summary: The study identified a significant number of multidrug-resistant ES beta L and carbapenemase-producing Enterobacteriaceae in street foods, suggesting they may be a potential source of multidrug-resistant foodborne infections. Regular examinations of street food items and tracking medication resistance trends are essential.
Article
Microbiology
Maya Frank Wolf, Raneen Abu Shqara, Karina Naskovica, Inna Amdur Zilberfarb, Inshirah Sgayer, Daniel Glikman, Hagai Rechnitzer, Vered Fleisher Sheffer, Jacob Bornstein
Summary: Maternal carriage and vertical transmission of ESBL-E pose a threat to preterm infants, leading to higher rates of complications. In this study, a correlation was found between placental inflammation and maternal ESBL-E colonization, highlighting the importance of surveillance and preventive measures.
Article
Public, Environmental & Occupational Health
Gunasekaran Rameshkumar, Ranjithkumar Dhandapani, Prajna Lalitha, Siva Ganesa Karthikeyan Rajapandian, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Abdullah A. Alyousef, Thamer Albalawi, Pravej Alam, Mohammad Zubair, Fayez M. Saleh, Fuad Abdullah Alatawi, Fohad M. Husain
Summary: In this study, the prevalence, antibacterial sensitivity patterns, and molecular characterization of MβL associated resistant genes in gram-negative bacteria isolated from ocular infections were investigated. The study found a high prevalence of MβL production in Pseudomonas aeruginosa, leading to high resistance to certain antibiotics. The bla(VIM) gene was also detected at a high rate in eye infections.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Mizuki Kusumoto, Tomoki Motegi, Haruna Uno, Mizuki Yokono, Kazuki Harada
Summary: This study investigated the pharmacokinetic indices of cefmetazole (CMZ) in dogs and performed pharmacokinetic-pharmacodynamic (PK-PD) analyses using Monte Carlo Simulation (MCS). The results showed that a regimen of 40 mg/kg every 6 hours of CMZ could be a viable treatment option for dogs infected with ESBL-producing Escherichia coli and Klebsiella pneumoniae.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Karyom Djim-Adjim-Ngana, Brunel W. Mbiakop, Leila A. Oumar, Hermann Munshili L. Njifon, Cedric Tchinda Fossi, Elisee L. Embolo Enyegue, Mohamed Mouiche M. Mouliom, Simeon P. Fodouop Chegaing, Louis Deweerdt, Nicolas Njintang Yanou, Julien A. Nguinkal
Summary: This study retrospectively determined the prevalence of multi-drug resistant ESBL strains isolated from UTIs in Northern Cameroon and evaluated the effectiveness of the ATB UR Gallery of BioMerieux in diagnosing ESBL-E. The study found high levels of drug resistance and diverse patterns of antibiotic resistance in ESBL-E strains. These findings emphasize the importance of implementing appropriate treatment guidelines and antimicrobial stewardship measures to prevent the spread and impact of multi-drug resistant strains on public health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Pharmacology & Pharmacy
Young R. Lee, Pamela D. Miller, Saeed K. Alzghari, Delilah D. Blanco, Jackson D. Hager, Kailey S. Kuntz
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2018)
Review
Pharmacology & Pharmacy
Young R. Lee, Pamela D. Miller, Saeed K. Alzghari, Delilah D. Blanco, Jackson D. Hager, Kailey S. Kuntz
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2018)
Review
Pharmacology & Pharmacy
Young R. Lee, Michael Sadanand Seth, Dylan Soney, Hanyu Dai
CLINICAL DRUG INVESTIGATION
(2019)
Review
Infectious Diseases
Young Ran Lee, Caitlin Elizabeth Burton
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Article
Pharmacology & Pharmacy
Young R. Lee, Peter J. Palmere, Caitlin E. Burton, Taylor M. Benavides
CLINICAL DRUG INVESTIGATION
(2020)
Review
Pharmacology & Pharmacy
Young Ran Lee, Katy Louise Jacobs
Letter
Pharmacology & Pharmacy
Young R. Lee
CLINICAL DRUG INVESTIGATION
(2020)
Review
Pharmacology & Pharmacy
Young Ran Lee, Suyeon Yeo
CLINICAL DRUG INVESTIGATION
(2020)
Letter
Pharmacology & Pharmacy
Young R. Lee
CLINICAL DRUG INVESTIGATION
(2021)
Article
Mathematics, Applied
Mi-Ran Choi, Dirk Hundertmark, Young -Ran Lee
Summary: We establish local and global well-posedness results for the Gabitov-Turitsyn or dispersion managed nonlinear Schrodinger equation with a wide range of nonlinearities and arbitrary average dispersion on L2(R) and H1(R) for zero and non-zero average dispersions, respectively. Additionally, we demonstrate the orbital stability of the set of ground states when the average dispersion is non-negative. This result covers both non-saturated and saturated nonlinear polarizations, and provides the first proof of orbital stability for saturated nonlinearities.
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS
(2023)
Article
Horticulture
Hyun Hwan Jung, Se Jin Kim, Gyeong-Rok Yang, Young -Ran Lee
Summary: This study aimed to enhance the rooting percentage and rootstock quality of Chamelaucium uncinatum 'Mars' and 'Early Nir' semi-hardwood cuttings through total immersion or foliar spray application of K-IBA. Results showed that total immersion in 2,000 and 4,000 mg/L K-IBA solutions for two minutes significantly increased rooting ratio for 'Mars' in May, while foliar spray with 500 and 1,000 mg/L K-IBA solutions increased rooting percentage for cuttings in September. For 'Early Nir' in October, immersion in K-IBA solution improved survival ratio and rooting percentage, with the best results obtained at 4,000 mg/L for two and four minutes. However, foliar application decreased rooting percentage with increasing spray time. Overall, foliar spray with 500 and 1,000 mg/L K-IBA solutions in September and total immersion in 4,000 mg/L K-IBA solution for two or four minutes in October can be recommended to improve the cutting propagation efficiency of semi-hardwood cuttings.
HORTICULTURAL SCIENCE & TECHNOLOGY
(2023)
Article
Immunology
Sang-Hyun Kim, Ji-Hyun Park, Sun-Jae Lee, Hee-Sung Lee, Jae-Kyung Jung, Young-Ran Lee, Hyun-Il Cho, Jeong-Ki Kim, Kyungjae Kim, Chan-Su Park, Chong-Kil Lee
Summary: The study aimed to develop an innovative strategy to induce potent cytotoxic T lymphocyte (CTL) responses against tumor epitopes. It was found that the use of tumor epitope-loaded nanoparticles (NPs) in combination with polyinosinic-polycytidylic acid (poly-IC) and anti-PD1 mAb significantly enhanced the immune response of tumor-specific CTLs and exhibited strong anti-tumor activity in tumor-bearing mice.
Article
Horticulture
O-Hyeon Kwon, Hyo-Gil Choi, Se-Jin Kim, Young-Ran Lee, Hyun-Hwan Jung, Ki-Young Park
Summary: This experiment investigated the year-round growth and yield changes of cut roses grafted onto three rootstocks in Korea. The grafted cut roses showed changes in stomata morphology and number according to the seasons. Grafted cut roses had higher photosynthetic efficiency and improved flower quality parameters compared to the scion.
Article
Pharmacology & Pharmacy
Young Ran Lee, Caitlin Elizabeth Burton, Kolton Rucks Bevel
JOURNAL OF PHARMACY TECHNOLOGY
(2019)