Article
Biochemistry & Molecular Biology
Fabia Judice Marques Viroel, Leticia Favara Laurino, Erika Leao Ajala Caetano, Angela Faustino Jozala, Sara Rosicler Vieira Spim, Thaisa Borim Pickler, Michelle Klein Sercundes, Marcela C. Gomes, Alessandre Hataka, Denise Grotto, Marli Gerenutti
Summary: The consumption of Ganoderma lucidum, a type of mushroom, has positive effects on gestational diabetes mellitus (GDM) and maternal-fetal health. Ganoderma lucidum contains various bioactive compounds that can regulate blood glucose and be used in anti-cancer therapy.
Article
Plant Sciences
Mohsen Marvibaigi, Seyed Morteza Hosseini, Neda Amini
Summary: The hydroalcoholic extract of Launaea acanthodes demonstrated potential radical scavenging activity and high levels of phenolic and flavonoid content. In vivo studies showed that the extract effectively lowered fasting blood glucose levels, increased body weight, restored altered food and water intake, improved lipid profiles, and ameliorated OGTT results in diabetic rats. Additionally, the extract improved histopathological changes in the pancreas, reduced oxidative stress markers, and reinstated levels of key liver enzymes in diabetic rats. Analysis of gene expression data revealed that the extract regulated glucose metabolism enzymes and pancreatic function, showing its hypoglycemic effects through antioxidant properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Ling-Ling Zhao, Emmanuel Ayobami Makinde, Opeyemi Joshua Olatunji
Summary: The ethyl acetate extract from Shorea roxburghii (SRE) was found to have a protective effect on diabetes-induced testicular damage, improving testicular function, reducing inflammation, and oxidative stress.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Article
Biochemistry & Molecular Biology
Zhu Zeng, Yi Yang, Xinxin Zhong, Fangyin Dai, Shangwu Chen, Xiaoling Tong
Summary: This study investigated the beneficial effects of Lactobacillus paracasei strain L14 on type 2 diabetes mellitus (T2DM) rats. The preventive supplementation of strain L14 showed excellent anti-diabetic effects, reducing hyperglycemia, protecting pancreatic beta-cell and liver function, and improving dyslipidemia and inflammation. The strain also modulated the gut microbiota to alleviate gut dysbiosis. The whole-genome sequencing of L14 identified genes related to antioxidant systems and other beneficial microbial metabolites, highlighting its potential applications in functional food and pharmaceutical industries.
Article
Multidisciplinary Sciences
Paramesh Shamanna, Mala Dharmalingam, Rakesh Sahay, Jahangir Mohammed, Maluk Mohamed, Terrence Poon, Nathan Kleinman, Mohamed Thajudeen
Summary: This study demonstrated significant improvements in glycemic variability, BMI, and blood pressure in type 2 diabetes patients through the use of the digital twin-enabled Twin Precision Treatment (TPT) Program.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Feng Zhang, Dan Chen, Liming Zhang, Qingyujing Zhao, Yage Ma, Xi Zhang, Shenglan Zhao, Chaoyin Chen
Summary: The study found that diaphragma juglandis extract could improve metabolic abnormalities in type 2 diabetic rats, including insulin resistance, abnormal lipid metabolism, liver damage, oxidative stress, and reduce inflammation. It also prevented the pathological damage of pancreas and liver, and intercepted the disorders of gut microbes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Chao Chen, Shuming Tan, Tingyuan Ren, Hua Wang, Xiaotong Dai, Hui Wang
Summary: This study investigated the hypoglycemic effects of polyphenol-rich Rosa roxburghii Tratt extract in a type 2 diabetes mouse model and found that it can improve glucose metabolism, alleviate liver fat damage, and enhance hepatic glycogen storage.
Article
Environmental Sciences
Wei Liu, Bin Wang, Shijie Yang, Tao Xu, Linling Yu, Xing Wang, Man Cheng, Min Zhou, Weihong Chen
Summary: The study found that propylene oxide (PO) exposure is positively associated with fasting plasma glucose levels and the risk of diabetes. PO exposure combined with DNA oxidative damage or lipid peroxidation may increase the risk of diabetes, and lipid peroxidation may partially mediate the PO exposure-induced elevation in blood glucose levels.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Maria Chiara Pelle, Isabella Zaffina, Michele Provenzano, Giovenale Moirano, Franco Arturi
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has strained healthcare systems globally, with lockdowns being a main containment strategy. Despite advancements in vaccines and targeted therapies, patients with comorbid diabetes remain at higher risk for severe outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al Senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
Summary: This study demonstrates that vitamin D can improve the harmful effects of type 2 diabetes by increasing insulin secretion and sensitivity, improving beta-cell function, reducing cortisol levels, and exerting anti-inflammatory and antioxidant effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ildete L. Ferreira, Solange Costa, Bruno J. Moraes, Ana Costa, Olga Fokt, Daniela Marinho, Vera Alves, Isabel P. Baptista, A. Cristina Rego
Summary: Periodontitis (PDT) and type 2 diabetes (T2D) have a bidirectional relationship and are associated with imbalanced oxidative stress and mitochondrial dysfunction. This study investigated the mitochondrial and redox (de)regulation in peripheral blood mononuclear cells (PBMCs) of T2D-PDT, PDT, T2D patients, and control individuals. The results showed that PBMCs from T2D-PDT patients exhibited significant redox changes, while PBMCs from PDT patients showed mitochondrial deregulation and reduced expression of Nrf2-target genes.
Review
Pharmacology & Pharmacy
Tingting Deng, Jinxin Du, Ying Yin, Baorui Cao, Zhiying Wang, Zhongwen Zhang, Meina Yang, Jinxiang Han
Summary: With the increasing life expectancy and changes in lifestyle, diabetes mellitus is becoming more prevalent worldwide. Rheum palmatum L., a natural botanical medicine, has been used for thousands of years in Eastern countries to prevent and treat diabetes mellitus. Rhein, the main active component of rhubarb, has been extensively studied for its clinical application. This review comprehensively summarizes the studies on the antidiabetic effects of rhein published over the past decade, including the biological characteristics of Rheum palmatum L., the pharmacological effects, and pharmacokinetic characteristics of rhein. The review demonstrates that rhein can prevent and treat diabetes mellitus by improving insulin resistance, exhibiting anti-inflammatory and anti-oxidative stress properties, and protecting islet cells, providing a theoretical basis for its application as an antidiabetic agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Qian Li, Guofu Zhang, Lixia Lin, Meng Wu, Xiyu Cao, Daxiang Xiao, Xiaoyi Wang, Xu Zhang, Shangzhi Xu, Xiating Li, Chunrong Zhong, Tianqi Tan, Xi Chen, Li Huang, Yu Zhang, Renjuan Chen, Xuezhen Zhou, Ting Xiong, Yuanjue Wu, Qin Gao, Jiangyue Wu, De Li, Wenli Cui, Menghan Tu, Huaqi Zhang, Siyu Yang, Jin Liu, Hongying Yang, Xuefeng Yang, Liping Hao, Nianhong Yang
Summary: This study found that higher plasma Mn levels in early pregnancy are associated with increased risk of gestational diabetes mellitus (GDM).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Claudia Silva, Nelson Andrade, Joao Tiago Guimaraes, Emilia Patricio, Fatima Martel
Summary: Obesity and T2DM are linked to increased cancer incidence and mortality, including breast cancer. This study explores the impact of high glucose, insulin, leptin, TNF-alpha, INF-gamma, and oxidative stress on breast cancer and non-cancer cell lines, and suggests that changes in glucose uptake mediated by GLUT1 may contribute to cancer progression. Additionally, the GLUT1 inhibitor BAY-876 shows promise as a potential new anticancer agent against breast cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Neda Roshanravan, Mohammad Alizadeh, Mohammad Asghari Jafarabadi, Naimeh Mesri Alamdari, Hamed Mohammadi, Nazila Farrin, Ali Tarighat-Esfanjani
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2019)
Article
Nutrition & Dietetics
Samaneh Rashvand, Majid Mobasseri, Ali Tarighat-Esfanjani
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2019)
Review
Chemistry, Medicinal
Arash Karimi, Ramin Ghodsi, Fateme Kooshki, Mozhdeh Karimi, Vahid Asghariazar, Ali Tarighat-Esfanjani
PHYTOTHERAPY RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Arash Karimi, Ata Mahmoodpoor, Fateme Kooshki, Hamid Reza Niazkar, Hamed Shoorei, Ali Tarighat-Esfanjani
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Fatemeh Naeini, Helda Tutunchi, Hamidreza Razmi, Ata Mahmoodpoor, Mahdi Vajdi, Pouria Sefidmooye Azar, Farzad Najifipour, Ali Tarighat-Esfanjani, Arash Karimi
Summary: Nano-curcumin supplementation has a beneficial effect on hematological indices and inflammatory biomarkers in critically ill patients with sepsis, making it a potentially useful adjuvant therapy. However, more trials are needed to further explore the effects of nano-curcumin in the management of sepsis and its complications.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Alireza Rahmani, Vahid Maleki, Bahram Niknafs, Omid Mohammad Tavakoli-Rouzbehani, Ali Tarighat-Esfanjani
Summary: This study aims to determine the efficacy of Nigella sativa (NS) oil supplementation on blood glucose, kidney function, inflammation, oxidative stress, quality of life, and depression in hemodialysis patients with diabetes. The results of this study may be helpful in better controlling blood sugar and kidney function, and reducing complications in diabetic hemodialysis patients.
Article
Integrative & Complementary Medicine
Alireza Rahmani, Bahram Niknafs, Mohsen Naseri, Maryam Nouri, Ali Tarighat-Esfanjani
Summary: This study found that Nigella sativa supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic hemodialysis patients.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Endocrinology & Metabolism
Maryam Nouri, Bahram Pourghassem Gargari, Pedram Tajfar, Ali Tarighat-Esfanjani
Summary: This systematic review analyzes a large number of studies and finds that whey protein (WP) has a positive impact on glycemic control, primarily through stimulating insulin and incretin secretion, slowing gastric emptying, and suppressing appetite.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Endocrinology & Metabolism
Maryam Nouri, Bahram Pourghassem Gargari, Zahra Ghasempour, Vahideh Sadra, Mohammad Asghari Jafarabadi, Arvin Babaei, Pedram Tajfar, Ali Tarighat-Esfanjani
Summary: This study aimed to investigate the effects of long-term whey protein consumption on women with type 2 diabetes. The results showed that the group consuming whey protein concentrate had significant improvements in waist circumference, serum malondialdehyde levels, and hunger sensation. Therefore, consumption of whey protein-fortified bread could be beneficial for women with type 2 diabetes.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Dentistry, Oral Surgery & Medicine
MohammadAmin Tarighat Esfanjani, Neda Gilani, Ali Tarighat Esfanjani, Amir Mohammad Nourizadeh, Elnaz Faramarzi, Somayeh Hekmatfar
Summary: This study investigated the relationship between MetS and oral and dental health in the adult population. The results showed that oral hygiene was worse in MetS patients compared to the healthy group. Further research and promotion of oral hygiene in the general population are suggested for better health outcomes.
Article
Biochemistry & Molecular Biology
Arash Karimi, Fatemeh Naeini, Hamid Reza Niazkar, Helda Tutunchi, Vali Musazadeh, Ata Mahmoodpoor, Vahid Asghariazar, Majid Mobasseri, Ali Tarighat-Esfanjani
Summary: This study investigated the effects of nano-curcumin on patients with sepsis and found that it could improve inflammatory biomarkers, endothelial function, and oxidative stress indices, as well as reduce the duration of mechanical ventilation and disease progression. However, it did not show significant improvements in biochemical factors and nutritional status.
Article
Biology
Lida Daeie-Farshbaf, Mehrangiz Ebrahimi-Mameghani, Parvin Sarbakhsh, Neda Roshanravan, Ali Tarighat-Esfanjani
Summary: The study found that early signs of adolescence may be related to health conditions such as eating disorders. Additionally, there are correlations between weight, body mass index, waist circumference, and different types of eating disorders.
BMC RESEARCH NOTES
(2021)
Article
Nutrition & Dietetics
Mahmoud Lali Sarab, Maryam Nouri, Ali Tarighat-Esfanjani
PROGRESS IN NUTRITION
(2019)
Article
Pharmacology & Pharmacy
Behnoush Hossein-Nia, Sirous Khorram, Hassan Rezazadeh, Abdolrasol Safaiyan, Rafigheh Ghiasi, Ali Tarighat-Esfanjani
ADVANCED PHARMACEUTICAL BULLETIN
(2018)
Review
Public, Environmental & Occupational Health
Elaheh Foroumandi, Mohammad Alizadeh, Sorayya Kheirouri, Naseh Esmaeili, Ali Tarighat Esfanjani
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2020)