Journal
CALCIFIED TISSUE INTERNATIONAL
Volume 103, Issue 2, Pages 175-188Publisher
SPRINGER
DOI: 10.1007/s00223-018-0408-2
Keywords
Malignant bone tumor; Osteosarcoma; ECRT; Extra corporeal irradiation; Raman spectroscopy; Demineralization; Amide I
Categories
Funding
- Indian Institute of Technology Delhi
- All India Institutes of Medical Sciences New Delhi
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The present study investigates Raman scattering of human bone irradiated with 50 Gy single dose during therapeutic treatment of Ewing and Osteosarcoma. Bone quality was evaluated via mineral-to-matrix ratio, degree of crystallinity, change in amount of calcium, and carbonate substitution. Alteration in collagen and its cross-links was quantified through second-derivative deconvolution of Amide I peak. A dose of 50 Gy radiation leads to almost 50% loss of mineral content, while maintaining mineral crystallinity, and small changes in carbonate substitution. Deconvolution of Amide I suggested modifications in collagen structure via increase in amount of enzymatic trivalent cross-linking (p < 0.05). Overall irradiation led to detrimental effect on bone quality via changes in its composition, consequently reducing its elastic modulus with increased plasticity. The study thus quantifies effect of single-dose 50 Gy radiation on human bone, which in turn is necessary for designing improved radiation dosage during ECRT and for better understanding post-operative care.
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