Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 164, Issue 3, Pages 298-303Publisher
SPRINGER
DOI: 10.1007/s10517-018-3976-2
Keywords
succinate; HIF-1 alpha; GABA shunt; hypoxia
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Hypoxia-induced immediate expression of transcription factor HIF-1 alpha in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
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