Article
Environmental Sciences
Xiaohan Yin, Rabia Zeb, Hui Wei, Ling Cai
Summary: DEHP, a plasticizer, is widely present in the global environment and has adverse effects such as endocrine disruption; acute exposure to DEHP in marine medaka led to impaired immunity, metabolism, and endocrine system; ferroptosis occurred in response to DEHP exposure in medaka, inducing cell death.
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Pengfei Hou, Wenting Dai, Yanshan Jin, Fengqi Zhao, Jianxin Liu, Hongyun Liu
Summary: This study demonstrates that DEHP exposure has adverse effects on lactation, including energy insufficiency, inflammation activation, oxidative stress aggravation, and disturbance of milk production. These findings are important for understanding the health risks of the plastic additive DEHP on female lactation dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Endocrinology & Metabolism
Luchen Yang, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong
Summary: This study found a potential association between DEHP exposure and BPH based on NHANES data, with a biphasic effect of DEHP concentration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
Summary: This study found that DEHP exposure exacerbated metabolic disorders in obese mice, but not in lean mice. The synergistic effects of obesity and DEHP regulated carbohydrate uptake, lipolysis, and abnormal adipose tissue, while obesity and DEHP differentially modulated transcriptomic changes in hepatic tissue.Obesity and DEHP exposure together caused early onset of metabolic disorders in obese mice through a potential mechanism involving Pparg, Lipe, Cd44, and Irs1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
XueXia Liu, YaNan Liu, Zi Teng, YuSheng Zhang, ZeLin Wang, Peng Zhu, MeiNa Xie, FuJun Liu
Summary: This study found that DEHP exposure reduces testis weight, serum testosterone levels, and sperm quality and function in male mice. DEHP exposure leads to decreased sperm count, motility, acrosome reaction rate, sperm-egg binding capacity, and blastocyte formation. DEHP also affects antioxidant indicators, protein expressions, cell proliferation, and apoptosis pathways in the testis.
Article
Food Science & Technology
Xinyue Sun, Wenyue Zhang, Yuqi Wang, Yilei Zhang, Xiaojing Liu, Xu Shi, Shiwen Xu
Summary: The combined exposure to DEHP and PS-MPs induced oxidative stress and activated the AMPK/ULK1 pathway, leading to renal autophagy.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Xian Qin, Keng Po Lai, Rudolf Shiu Sun Wu, Richard Yuen Chong Kong
Summary: This study investigated the effects of continuous exposure to 17 alpha-ethinylestradiol (EE2) on reproductive performance in marine medaka fish. The results showed that continuous EE2 exposure reduced fecundity and sperm motility, and caused dysregulation in testicular transcriptome. Key genes identified in this study can serve as biomarkers for assessing EE2-induced reduction in sperm motility.
MARINE POLLUTION BULLETIN
(2022)
Article
Environmental Sciences
Mei-Lun Huang, Pei-Ling Yen, Chun-Han Chang, Vivian Hsiu-Chuan Liao
Summary: Chronic DEHP exposure at levels less than an environmentally-relevant dose can cause dopaminergic neuron degeneration through mitochondrial dysfunction involving mitochondrial complex I and II. The effects of exposure are influenced by developmental stage and timing. The findings suggest that chronic DEHP exposure might elevate the risk of developing Parkinson's disease in humans.
ENVIRONMENTAL POLLUTION
(2022)
Article
Marine & Freshwater Biology
Samreen, Xiaona Zhang, Jun Wang, Yuejiao Li, Xuan Li, Yuqi Zheng, Muhammad Arif, Shaoguo Ru
Summary: This study found that prometryn, a widely detected triazine herbicide, has significant toxic effects on marine medaka embryos, including yolk sac shrinkage, heart malformations, delayed hatching time, increased heart rate, and hatching failure rate. It also caused obvious malformations and decreased body length in newly hatched larvae. Transcriptome analysis revealed that prometryn exposure affected the expression levels of several cardiac development-related genes in the larvae.
AQUATIC TOXICOLOGY
(2022)
Article
Marine & Freshwater Biology
Yuanyuan Bao, Yuxin Chen, Yixi Zhou, Qian Wang, Zhenghong Zuo, Chunyan Yang
Summary: This study investigated the reproductive toxicity of chronic diflubenzuron exposure in female marine medaka. The results showed that exposure to diflubenzuron resulted in reduced reproductive performance, altered ovarian histopathology, inhibited development of the F1 generation, and changes in hormone levels and gene expression. These findings highlight the importance of investigating the potential environmental risks of diflubenzuron in marine ecosystems.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Yao Li, Yun Zhao, Yu Lu, Xianxian Lu, Yingdan Hu, Qiulin Li, Menglei Shuai, Rui Li
Summary: Autism spectrum disorders (ASD), also known as childhood autism, are common neurological developmental disorders. This study found that perinatal exposure to DEHP can induce ASD-like behavioral changes in rat offspring, possibly through the activation of the mTOR signaling pathway and inhibition of autophagy in the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Reproductive Biology
Hongou Wang, Yu Zhu, Yulang Chi, Sijun Dong
REPRODUCTIVE TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Tingting Yuan, Yi Zhong, Yingge Wang, Ting Zhang, Rui Lu, Minya Zhou, Yaoyao Lu, Kunning Yan, Yajie Chen, Zhehui Hu, Jingyan Liang, Jianglin Fan, Yong Cheng
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Endocrinology & Metabolism
Guozhu Ye, Han Gao, Yi Lin, Dongxiao Ding, Xu Liao, Han Zhang, Yulang Chi, Sijun Dong
Article
Environmental Sciences
Yulang Chi, Yi Lin, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Pharmacology & Pharmacy
Yulang Chi, Hongou Wang, Yi Lin, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong
Article
Cell Biology
Guozhu Ye, Guoyou Chen, Han Gao, Yi Lin, Xu Liao, Han Zhang, Xinyu Liu, Yulang Chi, Qiansheng Huang, Huimin Zhu, Yuhua Fan, Sijun Dong
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Environmental Sciences
Hongou Wang, Peicliang Zhao, Qiansheng Huang, Yulang Chi, Sijun Dong, Jianglin Fan
Article
Environmental Sciences
Guozhu Ye, Dongxiao Ding, Han Gao, Yulang Chi, Jinsheng Chen, Zeming Wu, Yi Lin, Sijun Dong
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Cell Biology
Yajie Chen, Ahmed Bilal Waqar, Kazutoshi Nishijima, Bo Ning, Shuji Kitajima, Fumikazu Matsuhisa, Lu Chen, Enqi Liu, Tomonari Koike, Ying Yu, Jifeng Zhang, Yuqing Eugene Chen, Huijun Sun, Jingyan Liang, Jianglin Fan
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Toxicology
Han Gao, Guozhu Ye, Yi Lin, Yulang Chi, Sijun Dong
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Hematology
Haizhao Yan, Manabu Niimi, Fumikazu Matsuhisa, Huanjin Zhou, Shuji Kitajima, Yajie Chen, Chuan Wang, Xiawen Yang, Jian Yao, Dongshan Yang, Jifeng Zhang, Masami Murakami, Katsuyuki Nakajima, Yao Wang, Enqi Liu, Jingyan Liang, Y. Eugene Chen, Jianglin Fan
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Environmental Sciences
Lingli Min, Yulang Chi, Sijun Dong
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Multidisciplinary Sciences
Ying Yang, Jian Ding, Yulang Chi, Jianjun Yuan
SCIENTIFIC REPORTS
(2020)
Article
Environmental Sciences
Jinlan Liao, Shouping Ji, Yulang Chi
Summary: This study investigates the interaction between microplastics released by discarded masks and marine microbes, and analyzes the effects of mask quantity, time, and environment on microbial communities. The study finds significant variations in the diversity and richness of microbial communities on the surface of different quantities and durations of microplastics, and identifies a correlation with antibiotic resistance.
Article
Physiology
Yajie Chen, Ahmed Bilal Waqar, Haizhao Yan, Yanli Wang, Jingyan Liang, Jianglin Fan
JOURNAL OF VASCULAR RESEARCH
(2019)