Article
Biochemistry & Molecular Biology
Melissa Shen, Claudia Manca, Francesco Suriano, Nayudu Nallabelli, Florent Pechereau, Benedicte Allam-Ndoul, Fabio Arturo Iannotti, Nicolas Flamand, Alain Veilleux, Patrice D. Cani, Cristoforo Silvestri, Vincenzo Di Marzo
Summary: The endocannabinoidome-gut microbiome axis plays a fundamental role in controlling energy intake and metabolism. The liver-expressed antimicrobial peptide 2 (LEAP2) is a molecule that affects energy metabolism in the gastrointestinal system. This study investigates the role of this axis in the expression of LEAP2 in the liver and intestines, and suggests that LEAP2 from the small intestine may have an impact on food intake and energy metabolism.
Article
Pharmacology & Pharmacy
Mariarosaria Cammarota, Francesca Ferlenghi, Federica Vacondio, Fabrizio Vincenzi, Katia Varani, Annalida Bedini, Silvia Rivara, Marco Mor, Francesca Boscia
Summary: Inhibiting FAAH or stimulating melatonin receptors can enhance endocannabinoid and melatoninergic signaling, which may be beneficial for treating neuroinflammation and neurodegenerative diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Nicholas DiPatrizio
Summary: The gut-brain signaling system, particularly the endocannabinoid system in the upper gastrointestinal tract, plays a crucial role in controlling food intake and the dysregulation of this system is associated with obesity. Direct and indirect interactions between endocannabinoids and vagal afferent neurons are key mechanisms in this control, with a focus on how diet-induced obesity impacts these pathways.
Article
Immunology
Fredy Alexander Guevara Agudelo, Nadine Leblanc, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Sebastien Lacroix, Cyril Martin, Nicolas Flamand, Alain Veilleux, Vincenzo Di Marzo, Frederic Raymond
Summary: Dietary micronutrients, such as selenium, influence the gut microbiome and endocannabinoidome, which are associated with metabolic health and chronic low-grade inflammation. This study reveals that variations in selenium levels affect gut microbiota, circulating endocannabinoid mediators, and gene expression related to immune and antioxidant responses in the intestine, particularly in response to high-fat diets. These findings contribute to the development of new nutritional strategies for improving metabolic health.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Meera Manchanda, Emma Leishman, Kishan Sangani, Ali Alamri, Heather B. Bradshaw
Summary: This study investigates how activation of TRPV1 drives regulation of a wider range of lipid signaling molecules, which is time and dose-dependent. The analysis of lipids revealed that capsaicin increases the release of 2-acyl glycerols while decreasing levels of N-acyl ethanolamines. Changes in temperature also result in similar regulation of lipid signaling molecules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madis Parksepp, Liina Haring, Kalle Kilk, Kadri Koch, Kaert Uppin, Raul Kangro, Mihkel Zilmer, Eero Vasar
Summary: This study found alterations in the expanded endocannabinoid system and cell membrane composition in patients with schizophrenia spectrum disorders. The concentration of endocannabinoids and their precursors in the serum was associated with disease progression and treatment. These findings have important implications for understanding the metabolic changes in schizophrenia spectrum disorders.
Article
Chemistry, Applied
Yu Zhang, Xiaosan Wang, Xingguo Wang
Summary: This study investigated the acyl migration of DHA-rich 2-monoacylglycerols (2-MAGs) under different systems and temperatures. Increasing the temperature promoted acyl migration, resulting in a 5.6-fold increase from 20 degrees C to 50 degrees C. The rate constants followed a specific order depending on the solvent used and correlated with its log P. At 40 degrees C, DHA content in 2-MAGs was higher than in 1-MAGs, indicating slower acyl migration of DHA; while at 50 degrees C, the difference became smaller due to increased acyl migration rate. Therefore, acyl migration of different fatty acids can be controlled by changing conditions to enrich DHA at the sn-2 position.
Article
Biochemistry & Molecular Biology
Dolores Camacho-Munoz, Magdalena Kiezel-Tsugunova, Orsolya Kiss, Mohib Uddin, Mattias Sunden, Maria Ryaboshapkina, Lars Lind, Jan Oscarsson, Anna Nicolaou
Summary: In this study, the effects of Fibrates and omega-3 polyunsaturated acids on plasma levels of bioactive lipid mediators in patients with obese non-alcoholic fatty liver and hypertriglyceridemia were investigated. The results showed that these two drugs have different effects on the plasma mediator lipidome, with omega-3 promoting lipid mediators potentially affecting chronic inflammation, while Fibrates mainly reducing ceramides. These findings suggest that both treatments could alleviate chronic inflammation and possibly impact disease outcomes, independent of triglyceride reduction.
Article
Medical Laboratory Technology
Wei Gao, Unnur Anna Valdimarsdottir, Arna Hauksdottir, Johanna Eyrun Torfadottir, Clemens Kirschbaum
Summary: Hair analysis of endocannabinoids and N-acylethanolamines is a promising method for evaluating long-term secretion in stress-related research. This study explored the factors influencing the levels of these compounds in hair samples and found that gender, age, BMI, waist circumference, medication and drug use, and hair washing frequency were potential confounding variables.
CLINICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Melissa Simard, Anne-Sophie Archambault, Jean-Philippe C. Lavoie, Elizabeth Dumais, Vincenzo Di Marzo, Nicolas Flamand
Summary: This review discusses the biosynthesis and metabolism of endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-ethanolamine (AEA), as well as their congeners, with a special focus on the metabolism by oxygenases involved in arachidonic acid metabolism. The authors highlight the knowledge gaps in our understanding of the regulation and roles of the oxyendocannabinoidome mediators.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Margaux Nawrot, Simon Peschard, Sophie Lestavel, Bart Staels
Summary: Type 2 diabetes and Non-Alcoholic Fatty Liver Disease are influenced by the interaction between the intestine and the liver, particularly through changes in gut microbiota and intestinal permeability. Targeting intestinal functions may be a promising therapeutic approach for these metabolic diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Pharmacology & Pharmacy
Aidan Levine, Erika Liktor-Busa, Kelly L. Karlage, Luigi Giancotti, Daniela Salvemini, Todd W. Vanderah, Tally M. Largent-Milnes
Summary: Recent findings suggest that Clinical Endocannabinoid Deficiency is associated with pain disorders, and targeted regulation of the endocannabinoid system may induce headache pain. Inhibition of specific biosynthetic enzymes could lead to headache-like pain and photophobia, providing a valuable addition to headache models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sukanya Arul Prakash, Ravindar Chinapaka, Martin Luther John, Somnath Dey, Ravi Kanth Kamlekar
Summary: N-Acyltaurines (NATs) are functional lipids and bioactive fatty acid amides with various cellular and physiological roles. This study presents the crystal structure and molecular interactions of N-pentadecanoyltaurine (NPDT) and analyzes the interaction between NATs and cholesterol.
Article
Pharmacology & Pharmacy
Barbara Romano, Ester Pagano, Fabio A. Iannotti, Fabiana Piscitelli, Vincenzo Brancaleone, Giuseppe Lucariello, Maria Francesca Nani, Ferdinando Fiorino, Rosa Sparaco, Giovanna Vanacore, Federica Di Tella, Donatella Cicia, Ruggero Lionetti, Alexandros Makriyannis, Michael Malamas, Marcello De Luca, Giovanni Aprea, Maria D'Armiento, Raffaele Capasso, Bernardo Sbarro, Tommaso Venneri, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: The research shows the functional importance of N-acyl ethanolamine acid amidase (NAAA) in colorectal cancer (CRC) progression, with its inhibition counteracting tumor growth and affecting the composition of tumor secretome. NAAA is proposed as a valid drug target for the treatment of CRC growth and development.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Nadia Boachie, Erin Gaudette, Richard P. Bazinet, Lin Lin, Rachel F. Tyndale, Esmaeil Mansouri, Marilyn A. Huestis, Junchao Tong, Bernard Le Foll, Stephen J. Kish, Tony P. George, Isabelle Boileau
Summary: Our preliminary findings suggest that the activity of the endocannabinoid system is elevated in chronic cannabis users. Further studies are needed to examine endocannabinoids and NAEs during prolonged abstinence and the potential role of DHEA in craving.
Review
Biochemistry & Molecular Biology
Niels Wellner, Thi Ai Diep, Christian Janfelt, Harald Severin Hansen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2013)
Article
Biochemistry & Molecular Biology
Karen Kleberg, Louise Lundeman Nielsen, Nicolai Stuhr-Hansen, John Nielsen, Harald Severin Hansen
Review
Biochemistry & Molecular Biology
Karen Kleberg, Helle A. Hassing, Harald S. Hansen
Letter
Endocrinology & Metabolism
Harald S. Hansen, Lise Moesby, Michael Timm, Erik W. Hansen
Article
Endocrinology & Metabolism
Eva B. Nygaard, Sara G. Vienberg, Cathrine Orskov, Harald S. Hansen, Birgitte Andersen
EXPERIMENTAL DIABETES RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Christian Janfelt, Niels Wellner, Pierre-Louis Leger, Julia Kokesch-Himmelreich, Steen Honore Hansen, Christiane Charriaut-Marlangue, Harald Severin Hansen
Article
Endocrinology & Metabolism
M. F. Bennetzen, N. Wellner, S. S. Ahmed, S. M. Ahmed, T. A. Diep, H. S. Hansen, B. Richelsen, S. B. Pedersen
INTERNATIONAL JOURNAL OF OBESITY
(2011)
Article
Endocrinology & Metabolism
Katrine B. Hansen, Mette M. Rosenkilde, Filip K. Knop, Niels Wellner, Thi A. Diep, Jens F. Rehfeld, Ulrik B. Andersen, Jens J. Holst, Harald S. Hansen
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2011)
Article
Biochemical Research Methods
Christian Janfelt, Niels Wellner, Harald S. Hansen, Steen H. Hansen
JOURNAL OF MASS SPECTROMETRY
(2013)
Review
Pharmacology & Pharmacy
Harald S. Hansen
PHARMACOLOGICAL RESEARCH
(2014)
Article
Multidisciplinary Sciences
Thi Ai Diep, Andreas N. Madsen, Sandra Krogh-Hansen, Marwa Al-Shahwani, Laila Al-Sabagh, Birgitte Holst, Harald S. Hansen
Review
Pharmacology & Pharmacy
Harald S. Hansen, Mette M. Rosenkilde, Jens J. Holst, Thue W. Schwartz
TRENDS IN PHARMACOLOGICAL SCIENCES
(2012)
Letter
Biochemistry & Molecular Biology
Harald S. Hansen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Neurosciences
Harald S. Hansen
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2013)