Article
Cell Biology
Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao, Xiuli Zhou, Shiqi Liu, Qian Wang, Hong Zhang
Summary: This study identified a crucial gene, LILRB2, associated with the progression of peripheral atherosclerotic disease (PAD) through bioinformatics analysis. The role of this gene in PAD was validated using a mouse model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Yizhong Bao, Xihao Wang, Wei Mao, Xinyao Li, Jiangjie Lou, Weihua Jin, Genxiang Mao, Lijiang Tang, Yingzheng Weng
Summary: Atherosclerosis is the leading cause of cardiovascular diseases worldwide. This study investigated the anti-atherosclerosis activities of two types of oligosaccharides and found that sulfated glucuronomannan hexamer exhibited the best activity. It down-regulated the expression of LOX-1 and regulated multiple signaling pathways to reduce plaque progression and promote plaque stabilization.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Yuwen Shi, Mengcheng Jiang, Yuhang Zhang, Yuanyuan Diao, Na Li, Weipeng Liu, Zhidong Qiu, Ye Qiu, Ailing Jia
Summary: This study prepared hybrid nanomicelles containing hyperoside and evaluated their effects on atherosclerosis. The results showed that these nanomicelles reduced the aortic plaque area, lowered lipid levels, decreased inflammatory factors, and improved gut bacteria. The nanomicelles also regulated gut flora and lipid metabolism, and inhibited inflammatory responses. These beneficial effects may be mediated by inhibiting NF-κB signal activation and improving gut microflora and dyslipidemia.
Article
Food Science & Technology
Luanying He, Hui Weng, Qing Li, Guojun Shi, Xiuping Liu, Yushi Du, Jiakun Zheng, Wenhua Ling, Dongliang Wang
Summary: Lactucopicrin inhibits NF-kappa B activation in inflammed macrophages, reduces atherosclerotic plaque area and macrophage accumulation in mice, and does not affect serum lipid levels. It suggests that dietary supplementation with lactucopicrin is a promising strategy to inhibit atherosclerotic cardiovascular disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge
Summary: This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The results showed that moxonidine increased the uptake of oxidised LDL by vascular smooth muscle cells (VSMCs), as well as the expression of LDL receptors and the lipid efflux transporter ABCG1. Moxonidine also inhibited inflammatory gene expression and increased VSMC migration. In vivo experiments on ApoE(-/-) mice showed that moxonidine administration reduced atherosclerosis formation and increased plasma lipid hydroperoxide levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Frederick C. de Beer, Nancy R. Webb, Lisa R. Tannock, Preetha Shridas
Summary: Serum amyloid A (SAA) is predictive of cardiovascular disease (CVD) in humans and induces atherosclerosis in mice. However, the proatherogenic effects of SAA are masked by high-density lipoprotein (HDL), the major carrier of SAA. Cholesteryl ester transfer protein (CETP) remodels HDL, releasing SAA and restoring its proinflammatory activity. Inhibiting CETP may therefore benefit patients with high SAA levels.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Chunping Liu, Guiling Chen, Yanfen Chen, Yue Dang, Guangning Nie, Dinghong Wu, Jinhua Li, Zide Chen, Hailong Yang, Dongyue He, Xiong Li, Jingbo Sun, Jiahong Lu, Lei Wang
Summary: Atherosclerosis is a chronic vascular disease characterized by lipid deposition and plaque formation. Danlou tablets showed potential in reducing aortic atherosclerotic plaques and promoting macrophage autophagy, possibly through inhibiting the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shahan Syed, Eija Nissila, Hanna Ruhanen, Satoshi Fudo, Meztlli O. Gaytan, Sanna P. Sihvo, Martina B. Lorey, Jari Metso, Katariina Oorni, Samantha J. King, Oommen P. Oommen, Matti Jauhiainen, Seppo Meri, Reijo Kakela, Karita Haapasalo
Summary: Streptococcus pneumoniae pneumolysin (PLY) and neuraminidase A (NanA) can impair HDL function by causing chemical and structural modifications to HDL particles, resulting in significant changes in sialic acid, protein, and lipid compositions. Accumulation of these modified HDL particles in the arterial intima may trigger complement activation, inflammatory response, and promote the progression of atherogenic disease.
Article
Peripheral Vascular Disease
Byambasuren Ganbaatar, Daiju Fukuda, Masakazu Shinohara, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Ken-Ichi Hirata, Masataka Sata
Summary: The study indicates that using an S1P2 receptor antagonist can mitigate endothelial dysfunction and prevent atherosclerosis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Biochemistry & Molecular Biology
Akemi Kakino, Yoshiko Fujita, Liang-Yin Ke, Hua-Chen Chan, Ming-Hsien Tsai, Chia-Yen Dai, Chu-Huang Chen, Tatsuya Sawamura
Summary: Adiponectin has the ability to bind to and deactivate atherogenic LDL, thereby reducing its atherogenic effects by inhibiting LDL receptor endocytosis and cellular signaling pathways. This finding provides new insights into the antiatherogenic mechanisms of adiponectin.
JOURNAL OF LIPID RESEARCH
(2021)
Review
Peripheral Vascular Disease
A. D. Marais
Summary: This review discusses the functions, genetic variations, and clinical significance of apolipoprotein E in lipid metabolism, including its impact on dyslipidaemia, atherogenic disorders, and glomerulopathy. It also highlights the potential therapeutic approaches using mimetic peptides. Overall, apolipoprotein E plays a crucial role in determining lipid profiles and cardiovascular health, with implications for medical care improvement.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yiwen Zha, Yaoyao Lu, Ting Zhang, Kunning Yan, Wenwen Zhuang, Jingyan Liang, Yong Cheng, Yingge Wang
Summary: APOC3 deficiency in rabbits delays the formation of atherosclerosis induced by a high-fat diet, making it a potential novel therapeutic target for treating atherosclerosis.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Pharmacology & Pharmacy
He Yang, Zuodong Liu, Xiangka Hu, Xiaojuan Liu, Liuming Gui, Zengxiaorui Cai, Chunmei Dai
Summary: This study demonstrates that Panax notoginseng saponins (PNS) may inhibit the progression of atherosclerotic lesions through their anti-inflammatory effect. PNS can suppress the NF-kappa B signaling pathway and inhibit the expression of pro-inflammatory factors such as NF-kappa B p65, IL-6, IL-1 beta, TNF-alpha, and Calpain1.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Nutrition & Dietetics
Jessica Maria Abbate, Francesco Macri, Francesca Arfuso, Carmelo Iaria, Fabiano Capparucci, Carmelo Anfuso, Antonio Ieni, Luca Cicero, Giovanni Briguglio, Giovanni Lanteri
Summary: The study found that fish waste protein hydrolysates have significant effects in inhibiting atherosclerosis in mice, showing promising results in reducing obesity and improving lipid metabolism.
Article
Cell Biology
Gary Ro-Lin Chang, Wei-Yuan Cheng, Hueng-Chuen Fan, Hsiao-Ling Chen, Ying-Wei Lan, Ming-Shan Chen, Chih-Ching Yen, Chuan-Mu Chen
Summary: This study found that kefir peptides (KPs) have preventive effects on vascular calcification (VC) and osteoporosis in ApoE(-/-) mice fed a high-cholesterol atherogenic diet (AD). KPs alleviate the development of these diseases by reducing oxidative stress and inflammatory responses. These findings contribute to the application of KPs as preventive medicines for the treatment of hyperlipidemia-induced vascular and bone degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chuanrui Ma, Han Wu, Guangyan Yang, Jiaqing Xiang, Ke Feng, Jing Zhang, Yunqing Hua, Lin Kang, Guanwei Fan, Shu Yang
Summary: This study showed that calycosin protects against atherosclerosis through promoting autophagy, inhibiting foam cell formation, inflammation, and apoptosis. It also identified MLKL as a new autophagy regulator that is negatively regulated by KLF2. Mechanistically, calycosin's inhibitory effects on atherogenesis are mediated through the KLF2-MLKL signaling pathway modulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Shu Yang, Guangyan Yang, Han Wu, Lin Kang, Jiaqing Xiang, Peilin Zheng, Shanhu Qiu, Zhen Liang, Yan Lu, Lijing Jia
Summary: The study found that serum levels of miR-193b increased in individuals with type 2 diabetes and were negatively correlated with muscle mass. Functional studies showed that miR-193b could target PDK1 expression to inhibit the Akt/mTOR/p70S6 kinase pathway, leading to muscle loss and dysfunction. These findings suggest that miR-193b could be a potential therapeutic target for treating sarcopenia.
Article
Plant Sciences
Yuying Wang, Xiaoqing Sang, Rui Shao, Honglin Qin, Xuanhao Chen, Zhifeng Xue, Lin Li, Yu Wang, Yan Zhu, Yanxu Chang, Xiumei Gao, Boli Zhang, Han Zhang, Jian Yang
Summary: Xuanfei Baidu Decoction has protective effects against acute inflammation and pulmonary fibrosis by inhibiting the IL-6/STAT3 signaling pathway to protect against macrophage-induced inflammation and pulmonary fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ming Dong, Dishen Chen, Yanxia Zhu, Shu Yang, Santosh Kumar, Rui Zhang, Yin Zhou, Ziyi Yang, Na Zheng, Ting Zhu, Jiaqing Xiang, Yun Liu, Lin Kang, Jie Liu
Summary: This study found that aging increases the size of myocardial infarction and impairs cardiac contractile function. The expression of MLCK3 and the activity of MLC2 do not increase in the aging hearts after myocardial infarction. miR-146a-5p down-regulates MMP2/16 expression, which in turn increases MLCK3 expression and MLC2 activity. However, this regulatory mechanism is compromised in senescent cardiomyocytes or in hearts lacking miR-146a.
CARDIOVASCULAR RESEARCH
(2023)
Article
Plant Sciences
Yule Wang, Xinyan Liu, Wen Zhang, Shuang He, Yiqian Zhang, John Orgah, Yi Wang, Yan Zhu
Summary: This study explores the chemical basis and molecular mechanism of the anti-stroke therapy of QSYQ and its components YQ and HX. The results show that YQ and HX components synergistically protect the brain from cerebral ischemia/reperfusion injury by regulating inflammation and autophagy. These findings shed new light on the understanding of the traditional Chinese medicine principle of tonifying Qi and activating blood, particularly in ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chang Liu, Sijie Li, Xiaoxiao Zhang, Chunxiang Jin, Baofeng Zhao, Liying Li, Qing Robert Miao, Ying Jin, Zhimin Fan
Summary: NgBR plays a role in regulating metabolism and paclitaxel resistance in breast cancer, and may be a new therapeutic target for improving chemoresistance in ER-positive breast cancer.
CANCER GENE THERAPY
(2023)
Correction
Biotechnology & Applied Microbiology
Chang Liu, Sijie Li, Xiaoxiao Zhang, Chunxiang Jin, Baofeng Zhao, Liying Li, Qing Robert Miao, Ying Jin, Zhimin Fan
CANCER GENE THERAPY
(2023)
Article
Pharmacology & Pharmacy
Yuanli Chen, Shu Yang, Lipei Liu, Xiaoxiao Yang, Yajun Duan, Shuang Zhang, Jihong Han
Summary: In a mouse study, the combination therapy of rosiglitazone and fenofibrate showed better effects in reducing liver necrosis and serum biochemical parameters caused by cholestasis, while the combination therapy of UDCA and fenofibrate resulted in the accumulation of free fatty acids (FFAs) in the liver.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Shu Yang, Jiaqing Xiang, Chuanrui Ma, Guangyan Yang, Xinyu Wang, Hanyong Liu, Guanwei Fan, Lin Kang, Zhen Liang
Summary: This study identifies the role of KLF13 in regulating TGF-(3 signaling and fibrosis. KLF13 recruits a repressor complex to the target genes of TGF-(3, limiting its fibrotic effects. However, persistent activation of TGF-(3 signaling reduces KLF13 levels through degradation and transcriptional inhibition mechanisms, offsetting the anti-fibrotic effect of KLF13.
Article
Cell Biology
Shu Yang, Guangyan Yang, Xinyu Wang, Jiaqing Xiang, Lin Kang, Zhen Liang
Summary: This study demonstrates the anti-fibrotic role of SIRT2 in renal tubules and hepatocytes. SIRT2 inhibits fibrotic gene expression by reducing the activation of the TGF-beta signaling pathway. It interacts with and deacetylates SMAD2 and SMAD3 to promote their degradation and decrease the activation of SMAD3.
CELL DEATH & DISEASE
(2023)
Review
Endocrinology & Metabolism
Tingfeng Liao, Lijiao Xiong, Xiaohao Wang, Shu Yang, Zhen Liang
Summary: Obese sarcopenia is a severe and prevalent disease in an aging society, and its development is faster and more severe compared to sarcopenia alone. Obese patients are more likely to suffer from chronic inflammation and show mitochondrial metabolic disorders in their tissue cells. Currently, there are no effective pharmacological treatments available.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Lijiao Xiong, Tingfeng Liao, Tianting Guo, Zhaohao Zeng, Shuojia Wang, Guangyan Yang, Xiaohao Wang, Xinyu Wang, Jing Zhu, Pengfei Zhao, Yanchun Li, Lixing Li, Lin Kang, Shu Yang, Zhen Liang
Summary: This study assesses the significant impact of sarcopenia and its components on mortality risk in the Chinese population. Particularly, low hand grip strength and usual walking pace emerged as noteworthy contributors to mortality risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Shu Yang, Kewei Jiang, Lixing Li, Jiaqing Xiang, Yanchun Li, Lin Kang, Guangyan Yang, Zhen Liang
Summary: This study found that miR-92b-3p can attenuate renal fibrosis by suppressing the TGF-beta signaling pathway and directly targeting TGF-beta receptor 1. Additionally, TGF-beta inhibits the transcription of miR-92b through Snail family transcriptional repressors 1 and 2. MiR-92b-3p may serve as a novel therapeutic approach for mitigating fibrosis in CKD.
Article
Nutrition & Dietetics
Lijiao Xiong, Zhaohao Zeng, Shuojia Wang, Tingfeng Liao, Xiaohao Wang, Xinyu Wang, Guangyan Yang, Yanchun Li, Lixing Li, Jing Zhu, Pengfei Zhao, Shu Yang, Lin Kang, Zhen Liang
Summary: This study investigated the association between handgrip strength (HGS) and all-cause and cardiovascular disease (CVD) mortality in US adults. The results showed that individuals with low HGS had a higher risk of both all-cause and CVD mortality. Low HGS served as an independent risk factor for both outcomes.
FRONTIERS IN NUTRITION
(2023)
Article
Geriatrics & Gerontology
Shu Yang, Guangyan Yang, Xinyu Wang, Lixing Li, Yanchun Li, Jiaqing Xiang, Lin Kang, Zhen Liang
Summary: This study revealed that miR-92b regulates glycogen and lactate metabolism in skeletal muscle through pathways involving miR-92b-3p/UGP2/glycogen synthesis and miR-92b-5p/MCT4/lactate extrusion.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)