Article
Ophthalmology
Almut Bindewald-Wittich, Joanna Dolar-Szczasny, Sandrine H. Kuenzel, Leon von der Emde, Maximilian Pfau, Robert Rejdak, Steffen Schmitz-Valckenberg, Thomas Ach, Jens Dreyhaupt, Frank G. Holz
Summary: This study described the characteristics of fundus autofluorescence (FAF) in pigment epithelial detachments (PEDs) and observed accompanying FAF changes. The findings suggest that these changes in FAF signals may be related to morphological and metabolic alterations within corresponding retinal layers, rather than the underlying PED subtype or a specific pathology.
Article
Ophthalmology
Raziyeh Mahmoudzadeh, Mirataollah Salabati, M. Ali Khan, Sunir J. Garg, Jason Hsu
Summary: The study investigated the agreement between manual and semi-automated area measurements of geographic atrophy in eyes with age-related macular degeneration. Results showed that ImageJ is a reliable tool for GA area measurements when proprietary OCT software is unavailable. Manual and semi-automated measurements were comparable across different software platforms, and homogeneous GA lesions showed less disparity in area measurements.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Lorenzo Bianco, Alessio Antropoli, Alessandro Arrigo, Alessandro Berni, Lamberto La Franca, Andrea Saladino, Francesco Bandello, Maurizio Battaglia Parodi
Summary: This study found that EMAP and DTGA cannot be effectively differentiated on fundus autofluorescence. In both diseases, the macular atrophic area has a major vertical axis, fringed borders, and fast progression.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Optics
Yuan Xie, Wansheng Liu, Wanyuan Deng, Haimei Wu, Weiping Wang, Yichuan Si, Xiaowei Zhan, Chao Gao, Xian-Kai Chen, Hongbin Wu, Junbiao Peng, Yong Cao
Summary: This study reports on the potential applications of high-efficiency organic light-emitting diodes (OLEG) in the short-wavelength infrared (SWIR) region. By using specific types of molecules, researchers have successfully fabricated high radiance SWIR OLEGs, which have various applications in biosensors, biomedical imaging and spectroscopy, and surveillance.
Article
Ophthalmology
Ruben Jauregui, Yan Nuzbrokh, Pei-Yin Su, Jana Zernant, Rando Allikmets, Stephen H. Tsang, Janet R. Sparrow
Summary: The study compared the detection of retinal pigment epithelium (RPE) atrophy in Stargardt disease (STGD1) patients using short wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images. Results showed that NIR-AF revealed a larger area of RPE atrophy compared to SW-AF, but rates of lesion enlargement in the two modalities were similar.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Keshun Su, Yiyi Tao, Jun Zhang
Summary: A highly transparent film with ideal UV/HEB shielding was designed by adding UV absorbers and transparent yellow pigments to improve the UV/HEB shielding performance of PVC. It was demonstrated that UV326 UV absorber and 0.5 phr transparent yellow pigment could achieve more than 99% shielding effect in both UV and HEB regions, making the composite film suitable for various applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Ophthalmology
Xiaohui Wang, Zhaowei Song, Huazhang Li, Kexin Liu, Ying Sun, Xiangyu Liu, Meiyu Wang, Yuexing Yang, Sheng Su, Zhijian Li
Summary: The study found that short-wavelength blue light can induce pyroptotic programmed cell death in human lens epithelial cells, and that a caspase-1 inhibitor can suppress this cell death. The dose and time of blue light exposure have a dose-dependent effect on cell death.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.
Article
Ophthalmology
Carolina Madeira, Goncalo Godinho, Rodrigo Vilares-Morgado, Joao Beato, Joao Pinheiro-Costa, Angela Carneiro, Fernando Falcao-Reis, Manuel Falcao
Summary: The study aimed to assess the long-term risk of geographic atrophy (GA) progression after cataract surgery. Among the subjects with GA secondary to AMD, cataract surgery did not appear to increase the risk of GA progression, suggesting that it may be a safe therapeutic option for improving visual acuity and quality of life in GA patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Manrong Yu, Wangyuan Liu, Bingjie Wang, Jinhui Dai
Summary: The study showed that guinea pigs exposed to short-wavelength light were less likely to develop myopia compared to those under white light, with shorter axial length and lower retinal RA levels. Oral RA supplementation accelerated eye elongation, but the synthesis inhibitor citral equally slowed down eye growth under different light conditions, with no significant reduction in retinal RA levels.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Environmental Sciences
Xuhong Zhang, Xiaoyu Wang, Hong Zhu, Dongyan Zhang, Jinbo Chen, Yingying Wen, Yanqing Li, Le Jin, Chen Xie, Dongyu Guo, Ting Luo, Jianping Tong, Yudong Zhou, Ye Shen
Summary: Artificial light is crucial for modern life, but it can have negative effects on health. Exposure to short wavelength artificial light during early development in mice delays the development of the visual pathway and impairs neuronal structure and neurotransmitter function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Ophthalmology
Jeong Hyun Lee, Jeeyun Ahn, Joo Young Shin
Summary: The study investigated the temporal order of photoreceptor atrophy, retinal pigment epithelium (RPE) atrophy, and visual acuity loss in patients with center-involving geographic atrophy (GA) in non-exudative age-related macular degeneration (neAMD). The findings showed that photoreceptor atrophy on OCT and RPE atrophy on FAF preceded visual decline in the progression of center-involving GA.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Maximilian Pfau, Catherine A. Cukras, Laryssa A. Huryn, Wadih M. Zein, Ehsan Ullah, Marisa P. Boyle, Amy Turriff, Michelle A. Chen, Aarti S. Hinduja, Hermann Ea Siebel, Robert B. Hufnagel, Brett G. Jeffrey, Brian P. Brooks
Summary: This study aimed to analyze eye changes in patients with ABCA4-associated retinopathy. The study found that photoreceptors degenerate beyond EZ-loss in these patients, and there is an association between genotype, age, and photoreceptor degeneration.
Article
Multidisciplinary Sciences
Miho Tagawa, Sotaro Ooto, Kenji Yamashiro, Hiroshi Tamura, Akio Oishi, Akihito Uji, Manabu Miyata, Masahiro Miyake, Ayako Takahashi, Ai Ichioka, Akitaka Tsujikawa
Summary: The study found that the blood flow area of the choriocapillaris decreased diffusely within the macular area in eyes with PPE compared to healthy eyes. The choriocapillaris flow deficit was not necessarily related to the location of pachyvessels.
Article
Biology
Nicolas Nagloo, Jessica K. Mountford, Ben J. Gundry, Nathan S. Hart, Wayne I. L. Davies, Shaun P. Collin, Jan M. Hemmi
Summary: By studying the visual system of Tiliqua rugosa, researchers found that the species has enhanced short-wavelength sensitivity compared to other lizards. This sensitivity is driven by multiple factors, including a potentially red-shifted SWS1 photoreceptor and the absence of short-wavelength-absorbing oil droplets.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Ophthalmology
Riccardo Sacconi, Enrico Borrelli, Siva Balasubramanian, Giovanna Vella, Marco Battista, Kiran Kumar Vupparaboina, Jay Chhablani, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to investigate the choroidal vascularity index (CVI) in patients with leptochoroid. The results showed that the choroidal vascular and stromal components in eyes with leptochoroid secondary to reticular pseudodrusen (RPD) and high-myopia exhibited different changes. The impairment of the vascular area in RPD eyes might contribute to the lower development of RPD in patients with high myopia.
Article
Ophthalmology
Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H. Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani
Summary: This study analyzed the longitudinal changes in visual acuity and risk factors for recurrence or development of choroidal neovascularisation (CNV) in eyes with acute or chronic central serous chorioretinopathy (CSCR). The results showed that the recurrence rate of CNV was approximately 30%, and higher age and a higher number of recurrences were associated with a higher risk of early de novo CNV formation.
Article
Ophthalmology
Safa Halouani, Hoang Mai Le, Giuseppe Querques, Enrico Borrelli, Riccardo Sacconi, Marco Battista, Camille Jung, Eric H. Souied, Alexandra Miere
Summary: This study investigated choroidal involvement in eyes of patients treated with hydroxychloroquine (HCQ) by quantifying the choroidal vascularity index (CVI) and other choroidal biomarkers. The results showed that choroidal thickness and CVI were significantly decreased in patients with HCQ toxic retinopathy, especially in advanced stages.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Review
Medicine, General & Internal
Lyvia Zhang, Elon H. C. Van Dijk, Enrico Borrelli, Serena Fragiotta, Mark P. Breazzano
Summary: Optical coherence tomography (OCT) is a noninvasive imaging modality that uses low coherence light waves to assess ocular characteristics. OCT angiography (OCTA) is a functional extension that captures tissue and blood flow, allowing measurement of ischemia and vasculature demarcation. Different iterations of OCT, such as spectral-domain (SD) and swept-source (SS), have different wavelengths and tissue penetration capacities.
Article
Ophthalmology
Giovanni Staurenghi, Mariano Cozzi, SriniVas Sadda, Lauren Hill, Shamika Gune
Summary: This study aimed to reevaluate macular atrophy and macular neovascularization types using multimodal assessment and to determine the associations between baseline factors, ocular characteristics, and nAMD treatment and the development of macular atrophy. The findings suggested that macular neovascularization type 3 and fellow eye macular atrophy were strong predictors of new macular atrophy development at month 24. Other variables, including ranibizumab treatment, were not identified as risk factors.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Enrico Borrelli, Alessandro Berni, Maria Lucia Cascavilla, Costanza Barresi, Marco Battista, Giorgio Lari, Michele Reibaldi, Francesco Bandello, Piero Barboni
Summary: This retrospective study examined the relationship between demographics, clinical characteristics, and structural OCT findings and long-term visual outcomes in patients with LHON treated with idebenone therapy. The results showed that the thickness of GC-IPL in the macula was associated with final BCVA at 2 years in these patients.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Pasquale Viggiano, Maria Oliva Grassi, Giulia Bisceglia, Giacomo Boscia, Enrico Borrelli, Maria Giovanna Malerba, Antonio Fracchiolla, Giovanni Alessio, Francesco Boscia
Summary: This study aimed to evaluate short-term peripapillary structural and vascular changes in DME patients after treatment with DEX-I and anti-VEGFs. The results showed no significant short-term changes in peripapillary microvasculature, intraocular pressure (IOP), and peripapillary retinal nerve fiber layer (pRNFL) thickness in diabetic eyes treated with anti-VEGFs or DEX-I.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Marco Battista, Maria Lucia Cascavilla, Enrico Borrelli, Costanza Barresi, Giorgio Lari, Leonardo Caporali, Chiara Vigano, Alessandro Berni, Valerio Carelli, Francesco Bandello, Piero Barboni
Summary: The study aimed to compare the choroidal vascularity index (CVI) in patients with Leber hereditary optic neuropathy (LHON), dominant optic atrophy (DOA), and healthy subjects. The results showed that CVI remained stable in both DOA and LHON patients, suggesting that the choroidal structure is not irreversibly compromised even in the chronic phase of the neuropathy.
Review
Ophthalmology
Daniele Veritti, Valentina Sarao, Jay Chhablani, Anat Loewenstein, Paolo Lanzetta
Summary: This study reviewed the ideal setting for intravitreal injection (IVI) administration of vascular endothelial growth factor (VEGF) inhibitors and provided recommendations. The research utilized content analysis, literature review, and international survey methods. The findings suggest that different injection settings have no significant impact on perioperative complications, and choosing the appropriate clinical environment can optimize patient management and improve treatment effectiveness, quality, productivity, and capacity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daniele Veritti, Valentina Sarao, Francesco Di Bin, Paolo Lanzetta
Summary: This study evaluated the effects of different dosages and treatment regimens on intravitreal aflibercept concentrations and the proportion of free VEGF to total VEGF. The results showed that an 8 mg dosage administered every 12-15 weeks can effectively inhibit VEGF.
Review
Ophthalmology
Costanza Barresi, Jay Chhablani, Rosa Dolz-Marco, Robero Gallego-Pinazo, Alessandro Berni, Francesco Bandello, Enrico Borrelli
Summary: Age-related macular degeneration (AMD) is a complex and multifactorial disease that damages the unit comprising the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. While the outer retina is primarily affected, evidence suggests that the inner retina may also be impaired. Structural optical coherence tomography (OCT) technology has shown that both the inner and outer retina are impacted by AMD and that these impairments are associated. This review aims to describe the role of neurodegeneration in AMD to better understand the relationship between neuronal loss and outer retinal damage in this disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Pasquale Viggiano, Rosa Buonamassa, Maria Oliva Grassi, Giacomo Boscia, Enrico Borrelli, Luca Landini, Federica Evangelista, Maria Giovanna Malerba, Giovanni Alessio, Francesco Boscia
Summary: This study investigated the changes in retinal nerve fiber layer (RNFL) and radial peripapillary capillaries (RPC) on optical coherence tomography (OCT) angiography and OCT thickness associated with increased intraocular pressure after intravitreal injections. It found that acute intraocular pressure changes were associated with reduced RNFL thickness in patients undergoing intravitreal injections of anti-VEGF drugs for neovascular age-related macular degeneration.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Enrico Borrelli, Jonathan D. Oakley, Giorgio Iaccarino, Daniel B. Russakoff, Marco Battista, Domenico Grosso, Federico Borghesan, Costanza Barresi, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
Summary: The purpose of this study was to validate a deep learning algorithm for automated segmentation of intraretinal fluid (IRF), subretinal fluid (SRF), and neovascular pigment epithelium detachment (nPED) in neovascular age-related macular degeneration (nAMD). The results demonstrate that the deep learning-based algorithm achieved high accuracy for the segmentation of all fluid types in all models and readers.
Article
Ophthalmology
Enrico Borrelli, Maria Lucia Cascavilla, Giorgio Lari, Anna Maria De Negri, Marco Battista, Alice Galzignato, Catarina Coutinho, Alessandro Berni, Costanza Barresi, Guido Ricciotti, Francesco Bandello, Piero Barboni
Summary: The aim of this study was to investigate the prevalence and characteristics of PHOMS in patients with acute LHON. Structural OCT imaging revealed that PHOMS were present in 57.1% of the patients, mainly located in the temporal peripapillary sector. These findings suggest that PHOMS may be a characteristic feature of acute LHON.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Cell Biology
Simone Dal Bello, Deborah Martinuzzi, Yan Tereshko, Daniele Veritti, Valentina Sarao, Gian Luigi Gigli, Paolo Lanzetta, Mariarosaria Valente
Summary: This review discusses the established standards of care for optic pathway gliomas (OPGs), and highlights emerging therapeutic strategies and potential alternative therapies for OPG treatment. It also addresses the challenges of restoring visual function in cases of optic nerve damage and explores ongoing research in this area, particularly involving stem cells.