4.4 Article

Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study

Journal

BRITISH JOURNAL OF NUTRITION
Volume 119, Issue 4, Pages 442-455

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114517003762

Keywords

Diabetes; Glucose; Dairy products; Fermentation; Cohorts

Funding

  1. FrieslandCampina

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Previous studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly diagnosed type 2 diabetes (ND-T2DM) among Dutch adults. In total, 112 086 adults without diabetes completed a semi-quantitative FFQ and donated blood. Pre-diabetes was defined as fasting plasma glucose (FPG) between 5.6 and 6.9 mmol/l or HbA1c% of 5.7-6.4 %. ND-T2DM was defined as FPG >= 7.0 mmol/l or HbA1c >= 6.5 %. Logistic regression analyses were conducted by 100 g or serving increase and dairy tertiles (T1(ref)), while adjusting for demographic, lifestyle and dietary covariates. Median dairy product intake was 324 (interquartile range 227) g/d; 25 549 (23 %) participants had pre-diabetes; and 1305 (1 %) had ND-T2DM. After full adjustment, inverse associations were observed of skimmed dairy (OR100 g 0.98; 95 % CI 0.97, 1.00), fermented dairy (OR100 g 0.98; 95 % CI 0.97, 0.99) and buttermilk (OR150 g 0.97; 95 % CI 0.94, 1.00) with pre-diabetes. Positive associations were observed for full-fat dairy (OR100 g 1.003; 95 % CI 1.01, 1.06), non-fermented dairy products (OR100 g 1.01; 95 % CI 1.00, 1.02) and custard (ORserving/150 g 1.13; 95 % CI 1.03, 1.24) with pre-diabetes. Moreover, full-fat dairy products (ORT3 1.16; 95 % CI 0.99, 1.35), non-fermented dairy products (OR100 g 1.05; 95 % CI 1.01, 1.09) and milk (ORserving/150 g 1.08; 95 % CI 1.02, 1.15) were positively associated with ND-T2DM. In conclusion, our data showed inverse associations of skimmed and fermented dairy products with pre-diabetes. Positive associations were observed for full-fat and non-fermented dairy products with pre-diabetes and ND-T2DM.

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