Review
Pediatrics
Trevor K. Young, Alexander F. Glick, H. Shonna Yin, Avani M. Kolla, Jessica J. Velazquez, Joey Nicholson, Vikash S. Oza
Summary: This review examines the management of pediatric atopic dermatitis by primary care providers, revealing common practices such as prescribing low-potency corticosteroids, overprescribing nonsedating antihistamines, and avoiding calcineurin inhibitors. PCPs typically recommend emollients, but there is limited data on nonmedication management.
ACADEMIC PEDIATRICS
(2021)
Review
Dermatology
Sara Sadeghi, Nessa Aghazadeh Mohandesi
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease with dysregulated immune systems. JAKi show promise as a novel treatment for AD by reducing pro-inflammatory cytokine production. A systematic review was conducted to evaluate the efficacy and safety of topical JAKi in adults and pediatrics with AD. The review identified 19 studies demonstrating the effectiveness of topical delgocitinib, tofacitinib, ruxolitinib, cerdulatinib, and ifidancitinib in improving AD symptoms. Minimal adverse effects were observed with topical JAKi. Further studies are needed for longer-term assessment and comparative trials.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Mutong Zhao, Yuan Liang, Fengli Song, Lili Ma, Ying Wang, Wanli Gao, Jing Tian, Xiangji Ying, Chunping Shen, Shan Wang, Lei Jiao, Yang Wang, Xiaoyan Sun, Lin Ma, Xiuhua Ma
Summary: This study aims to evaluate the effect of a preventive antenatal educational program on allergic diseases (PAEPAD) on the incidence of infantile allergic diseases. A total of 2266 expecting mothers will be recruited in a single-center randomized controlled trial in Beijing. The results of this study will provide valuable information for primary prevention of infantile allergic diseases.
Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema, developed according to the EuroGuiDerm Guideline and Consensus Statement Development Manual, involves the participation of 29 experts from 12 European countries. The first part of the guideline provides general information, guidance, and detailed information on systemic treatment options, including conventional immunosuppressive drugs, biologics, and janus kinase inhibitors. The second part will cover other aspects of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Health Policy & Services
Emily A. Croce, Paul J. Rathouz, Fabiana Castro Porto Silva Lopes, Maria Leszczynska, Lucia Z. Diaz, Moise L. Levy, Jennifer S. Ruth, Pooja Varshney, Lynn Rew, Elizabeth C. Matsui
Summary: The study found that many caregivers feel that primary care providers and specialists equally listen to their child's AD concerns, but they prefer to see a specialist for ongoing management.
JOURNAL OF PEDIATRIC HEALTH CARE
(2022)
Review
Dermatology
Stephan Weidinger, Audrey Nosbaum, Eric Simpson, Emma Guttman
Summary: Atopic dermatitis is often misdiagnosed and undertreated, leading to increased morbidity. The Atopic Dermatitis Quality of Care Initiative was launched globally in 2019 to investigate barriers to care and identify good practice interventions. Educating healthcare providers and the public, using screening surveys, following established guidelines, and improving communication through EHRs are the most frequently used strategies in AD care.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Partik Singh, Jonathan I. Silverberg
Summary: This study analyzed outpatient healthcare utilization trends and determinants for atopic dermatitis (AD) in US adults and children. The results showed an overall increase in AD visits over time, particularly among primary care physicians (PCPs). Children aged 0-4 years were the most common age group seeking outpatient care for AD.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger, Constanze Mueller
Summary: Atopic eczema is an inflammatory skin disorder that affects approximately 20% of children worldwide, and early onset can lead to other allergic diseases. Metabolomics can be used to observe the mechanisms of this disease and potentially discover new drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Nicole S. Stefanko, Victor L. Quan, Raj Chovatiya
Summary: This study investigates the diagnostic delay in an autoimmune skin disease. The use of C3d and C4d immunohistochemistry is found to be a valuable tool in the diagnosis of inflammatory skin diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Anne Birgitte Simonsen, Jojo Biel-Nielsen Dietz, Jeanne Duus Johansen
Summary: This study aimed to explore the epidemiology, aetiology and severity of hand eczema (HE) among Danish adolescents. The study found a high prevalence of HE among Danish adolescents, raising concerns about this significant clinical problem.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Linde E. M. de Wijs, Sven van Egmond, Arjan C. A. Devillers, Tamar Nijsten, DirkJan Hijnen, Marjolein Lugtenberg
Summary: In order to meet the needs of patients with atopic dermatitis, a personalized approach to care is necessary. Patients emphasize the importance of individualized consultations and recognition of the impact of the disease, as well as the need for psychosocial and medical supportive care. In the decision-making process, patient factors should be considered, including the information provided, the roles of the patient and physician, treatment goal setting, and the feasibility of novel therapies.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Immunology
Paola Facheris, Jane Jeffery, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis (AD) is a complex and heterogeneous inflammatory skin disease. Different phenotypes of AD based on patient characteristics have been defined, emphasizing the need for personalized treatment. Advances in understanding AD pathogenesis have led to an expansion in therapeutic options. Biomarkers in clinical studies are helping to clarify the role of cytokines and immune pathways in AD and enable personalized medicine. This review discusses changes in the understanding and treatment of AD, highlighting the scientific rationale behind targeted treatments and presenting recent clinical efficacy data.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Justin Choi, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P. Alphonse, Shawn G. Kwatra, Madan M. Kwatra
Summary: The complexity of atopic dermatitis poses a challenge in selecting an appropriate mouse model, as no single model can fully replicate all aspects of the human condition. Recent evidence has identified distinct endotypes of AD, characterized by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. While all AD mouse models consistently show Th2 inflammation, only some also exhibit Th17 and/or Th22 induction, highlighting the need for a closer evaluation of their immunological signature to enhance their relevance to human AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Richard B. Warren, Victoria Basey, Anita Lynam, Charlotte Curtis, Michael R. Ardern-Jones
Summary: A UK study found that people with atopic dermatitis (AD) have a 30% higher risk of deep-vein thrombosis and a 17% higher risk of venous thromboembolism (VTE). The increased VTE risk is lower in younger individuals and those without obesity. Identifying AD patients at higher VTE risk could impact clinical decision-making.
BRITISH JOURNAL OF DERMATOLOGY
(2023)