Review
Critical Care Medicine
Ignace De Decker, Henk Hoeksema, Jozef Verbelen, Els Vanlerberghe, Petra De Coninck, Marijn M. Speeckaert, Phillip Blondeel, Stan Monstrey, Karel E. Y. Claes
Summary: Fluid silicone gels have both prophylactic and curative effects on scars, but there is a high risk of bias and uncertainty in comparing their effects with silicone sheets.
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Melazzini, Paolo Vitali, Emanuele Olivieri, Marco Bolchini, Moreno Zanardo, Filippo Savoldi, Giovanni Di Leo, Ludovica Griffanti, Giuseppe Baselli, Francesco Sardanelli, Marina Codari
Summary: The study aimed to determine a point estimate and reference standard for WMH volume in the healthy aging population. However, lack of standardization in WMH definition and high technical variability in assessment explain observed heterogeneity. Currently, volumes of WMH in healthy subjects are not comparable between studies.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Sport Sciences
Elaine M. Murtagh, Jacqueline L. Mair, Elroy Aguiar, Catrine Tudor-Locke, Marie H. Murphy
Summary: This study provides clarity on the walking speed and intensity of apparently healthy adults in outdoor settings. The findings suggest that pace-based instructions can support walking in outdoor environments within public health guidelines.
Review
Nutrition & Dietetics
Ying Wang, Zhuang Tian, Zhenyu Li, Jae Cheol Kim
Summary: Flavonoids have been found to enhance athletic performance through various mechanisms, but conflicting results exist in the literature. A comprehensive review and meta-analysis indicate that flavonoid supplementation can improve performance tests and exercise tolerance.
Review
Immunology
Catherine P. Walsh, Emily K. Lindsay, Philip Grosse, Brianna N. Natale, Samantha Fairlie, Amanda Bwint, Luke Schaffer, Katie McMahon, Colin Del Duke, Jenny Forse, Noemi Lamonja-Vicente, Anna L. Marsland
Summary: Single assessments of inflammatory biomarkers may be sufficient for evaluating stable individual differences in the short term, while repeated measurements are recommended over intervals of 6 months to 3 years and absolutely necessary over intervals exceeding 3 years to reliably identify stable individual differences in health risk. These findings align with stability estimates and clinical recommendations for other cardiovascular risk measures.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Dermatology
Trinidad Montero-Vilchez, Raquel Sanabria-de-la-Torre, Manuel Sanchez-Diaz, Clara Urena-Paniego, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Skin barrier dysfunction is a significant factor in the development of atopic dermatitis. Dupilumab, an IL-4 and IL-13 inhibitor, has been shown to be effective in treating AD, but its effects on the epidermal barrier are not well studied. This systematic review aimed to evaluate the impact of dupilumab on skin barrier using non-invasive tools. Six prospective observational studies with a total of 233 participants were included. Dupilumab improved clinical scores and decreased transepidermal water loss (TEWL) on eczematous lesions and non-involved skin. Some studies also reported increased stratum corneum hydration (SCH) on eczematous lesions. Overall, dupilumab improved skin barrier function in AD patients, primarily demonstrated by decreased TEWL values.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Maria Salazar-Nievas, Jesus Tercedor-Sanchez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: The study aimed to evaluate the impact of dupilumab on skin barrier function in patients with atopic dermatitis (AD) and compare it with other treatments. The study found that dupilumab was more effective in improving barrier function in both eczematous lesions and non-lesioned skin compared to topical corticosteroids and cyclosporine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lili Liu, Wei Chen, Dan Wu, Fang Hu
Summary: This meta-analysis and systematic review suggests that time-restricted eating may be an effective approach to improving the metabolic state of nonobese individuals, particularly overweight individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Aglaia Forrer, Thomas Gaisl, Ahmet Sevik, Michelle Meyer, Luzi Senteler, Mona Lichtblau, Konrad Ernst Bloch, Silvia Ulrich, Michael Furian
Summary: This study aims to calculate the effect size estimate for the decrease in Pao(2) with each kilometer of vertical gain and to identify factors associated with Pao(2) at high altitude. Through the analysis of 53 prospective studies, it was found that the mean decrease in Pao(2) was 1.60 kPa per 1000 m of vertical ascent, and factors such as target altitude, age, and time spent at altitude were significantly associated with Pao(2).
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.
Article
Medicine, General & Internal
Qingyang Shi, Yang Wang, Qiukui Hao, Per Olav Vandvik, Gordon Guyatt, Jing Li, Zhe Chen, Shishi Xu, Yanjiao Shen, Long Ge, Feng Sun, Ling Li, Jiajie Yu, Kailei Nong, Xinyu Zou, Siyi Zhu, Cong Wang, Shengzhao Zhang, Zhi Qiao, Zhongyu Jian, Ya Li, Xinyi Zhang, Kerun Chen, Furong Qu, Yuan Wu, Yazhou He, Haoming Tian, Sheyu Li
Summary: This study summarised the latest evidence on the benefits and harms of weight-lowering drugs. The findings suggest that the combination of phentermine-topiramate and GLP-1 receptor agonists is the most effective, with semaglutide potentially being the most effective GLP-1 receptor agonist.
Review
Medicine, General & Internal
Larissa Donatoni da Silva, Agnes Shiel, Caroline McIntosh
Summary: Pilates may be effective in decreasing the risk of falls in older adults. Pilates intervention was found to improve functional mobility, mobility, gait, fear of falling and postural stability and therefore there is some evidence to suggest that Pilates reduces certain risk factors for falls in healthy older adults. However, there is an absence of high-quality evidence in regards to the impact of Pilates on reducing falls and further robust RCTs are needed.
FRONTIERS IN MEDICINE
(2021)
Review
Food Science & Technology
Mahdieh Abbasalizad-Farhangi
Summary: This meta-analysis evaluated the association between central obesity and leukocyte telomere length in adults. The results showed a negative association between higher leukocyte telomere length and waist circumference, while the association with waist to hip ratio was not significant.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Geriatrics & Gerontology
Everson A. Nunes, Lauren Colenso-Semple, Sean R. McKellar, Thomas Yau, Muhammad Usman Ali, Donna Fitzpatrick-Lewis, Diana Sherifali, Claire Gaudichon, Daniel Tome, Philip J. Atherton, Maria Camprubi Robles, Sandra Naranjo-Modad, Michelle Braun, Francesco Landi, Stuart M. Phillips
Summary: A systematic review and meta-analysis showed that increasing daily protein ingestion may contribute to gains in lean body mass (LBM) and muscle strength, especially in subjects participating in resistance exercise training. However, the effects on handgrip strength and physical function test performance are unclear.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Geriatrics & Gerontology
Huan-Huan Zhou, Yuxiao Liao, Zhao Peng, Fang Liu, Qi Wang, Wei Yang
Summary: This study examines the relationship between muscle wasting and mortality risk, finding that muscle wasting is associated with higher risks of all-cause mortality, cardiovascular disease mortality, cancer mortality, and respiratory disease mortality. Early detection and treatment of muscle wasting may be crucial for reducing mortality risk and promoting healthy longevity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Dermatology
Cristina Has, Moritz Hess, Waltraud Anemueller, Ulrike Blume-Peytavi, Steffen Emmert, Regina Foelster-Holst, Jorge Frank, Kathrin Giehl, Claudia Guenther, Johanna Hammersen, Kathrin Hillmann, Bettina Hoeflein, Peter H. Hoeger, Alrun Hotz, Thuy Anh Mai, Vinzenz Oji, Holm Schneider, Kira Suessmuth, Iliana Tantcheva-Poor, Frederieke Thielking, Birgit Zirn, Judith Fischer, Antonia Reimer-Taschenbrecker
Summary: This study reports the epidemiological data of EB in Germany, showing the incidence and prevalence of different types of EB. The findings are important for informing national policies, drug development, and improving the quality of life for EB patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Jan Kottner, Kathrin Hillmann, Alexandra Fastner, Romy Conzade, Stephanie Heidingsfelder, Konrad Neumann, Ulrike Blume-Peytavi
Summary: Regular emollient application during the first year of life does not prevent the development of atopic dermatitis. A standardized skin care regimen does not delay skin barrier development or cause side effects.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Brett King, Arash Mostaghimi, Yutaka Shimomura, Abraham Zlotogorski, Gwang-Seong Choi, Ulrike Blume-Peytavi, Thierry Passeron, Katrin Holzwarth, Yves Dutronc, Jill McCollam, Fan Emily Yang, Sarah Stanley, Wen-Shuo Wu, Rodney Sinclair
Summary: This study analyzed the safety data of baricitinib in patients with severe alopecia areata from two clinical trials. The results showed that the safety profile of baricitinib was consistent and no deaths were reported.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Rosalind C. Simpson, Gudula Kirtschig, Amanda Selk, Suzanne von Seitzberg, Gitte Vittrup, Ione Bissonnette, Jan Kottner, Jaclyn Lanthier, Chris Stanton, David Foster, Martin Promm, Angelo Augenti, Stefano Lauretti, Kim S. Thomas
Summary: This article summarizes the international consensus process on which outcome domains should be measured in interventional trials of genital lichen sclerosus. Three key outcome domains have been agreed upon and it is recommended that researchers incorporate them into study protocols with immediate effect.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Mona Prendke, Varvara Kanti-Schmidt, Doris Wilborn, Kathrin Hillmann, Rashmi Singh, Annika Vogt, Jan Kottner, Ulrike Blume-Peytavi
Summary: Alopecia areata (AA) is an autoimmune-mediated non-scarring hair loss that has a stigmatizing effect and can severely impact psychosocial well-being. Previous research has shown a correlation between AA and bullying, reduced quality of life, and psychiatric comorbidities. This review aims to systematically describe the quality of life among children and adolescents affected by AA, as no previous systematic evaluation has been performed on this population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
F. Rancan, K. Rajes, P. Sidiropoulou, S. Hadam, X. Guo, F. Zabihi, U. Mirastschijski, E. Ruehl, R. Haag, U. Blume-Peytavi, A. Vogt
Summary: Rapamycin, a potential anti-proliferative drug, has limitations in topical treatment of skin disorders due to its high molecular weight and lipophilicity. This study demonstrated that oxidation-sensitive CMS nanocarriers improved drug delivery to the skin and showed mTOR inhibitory activity in an inflammatory ex vivo human skin model. The osCMS formulations achieved higher anti-inflammatory effects and downregulated mTOR activity, suggesting their potential use in topical anti-inflammatory therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nursing
Bettina Voelzer, Monira El Genedy-Kalyoncu, Alexandra Fastner, Tsenka Tomova-Simitchieva, Konrad Neumann, Janna Sill, Katrin Balzer, Jan Kottner
Summary: The increase in elderly and care-dependent people has led to an increase in adverse skin conditions. Skin care is essential in long-term residential settings, and the study aimed to describe the prevalence and associations of skin conditions in aged nursing home residents.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Review
Medicine, General & Internal
Jan Kottner, Alexandra Fastner, Dimitra-Aikaterini Lintzeri, Christopher E. M. Griffiths, Ulrike Blume-Peytavi
Summary: Ageing is accompanied by physical and physiological changes in the skin, which require proper care and monitoring to prevent or manage dermatological diseases. This scoping review aims to describe and summarize the available evidence on screening, diagnosis, and management of skin conditions in older people living at home, as currently there is no organized body of evidence in this area.
Review
Dermatology
Lawrence A. Schachner, Ulrike Blume-peytavi, Anneke Andriessen, Jan Izakovic, Annabel Maruani, Giuseppe Micali, Nikolay Murashkin, Carmen Salavastru, Antonio Torrelo
Summary: The skin barrier of newborns and infants is immature, making them more susceptible to skin problems. The current algorithm focuses on promoting a healthy skin barrier and preventing atopic dermatitis through non-prescription skincare.
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Nursing
Bettina Voelzer, Monira El Genedy-Kalyoncu, Alexandra Fastner, Tsenka Tomova-Simitchieva, Konrad Neumann, Kathrin Hillmann, Ulrike Blume-Peytavi, Elisabeth Hahnel, Janna Sill, Katrin Balzer, Jan Kottner
Summary: The study aimed to evaluate the effects of implementing a skincare and prevention package on older nursing home residents. The results indicate that tailored and evidence-based nursing routines can improve skin health and safety in residential long-term care, but there was no significant impact on the skin barrier function.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2024)
Review
Dermatology
Rashmi Singh, Doris Wilborn, Dimitra-Aikaterini Lintzeri, Ulrike Blume-Peytavi
Summary: Cicatricial alopecia can have a significant impact on emotional well-being, social functioning, and overall quality of life. This review aimed to systematically describe the health-related quality of life in adults with primary cicatricial alopecia and its subtypes. The findings from thirteen observational cross-sectional and one single-arm study showed that more than 70% of patients experience impaired quality of life. The study suggests the importance of integrating psychosocial interventions with cicatricial alopecia treatments, and calls for further research to address the unmet mental health needs of this patient population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, General & Internal
Julie Deprez, Jan Kottner, Alexandra Eilegard Wallin, Nils Ohde, Carina Baath, Ami Hommel, Lisa Hultin, Anna Josefson, Dimitri Beeckman
Summary: This study aims to identify prognostic factors associated with the development of IAD and improve management, prevention, and future research. Multiple observational studies or clinical trials will be assessed, and the results will be published in a peer-reviewed scientific journal.
Review
Medicine, General & Internal
Max Zilezinski, Natascha-Elisabeth Denninger, Antje Tannen, Jan Kottner
Summary: This scoping review aims to identify and summarize the evidence on non-pharmacological interventions for the prevention and management of pediatric delirium, and provide relevant methods and recommendations.
Editorial Material
Dermatology
Jan Kottner, Andrea Pokorna
JOURNAL OF WOUND CARE
(2023)