Article
Oncology
Julia Foldi, Anastasia Tsagianni, Max Salganik, Catherine A. Schnabel, Adam Brufsky, G. J. van Londen, Lajos Pusztai, Tara Sanft
Summary: Extending adjuvant endocrine therapy beyond the standard 5 years can protect against late breast cancer recurrences. This study evaluated persistence to extended therapy in women who had Breast Cancer Index testing, and found high rates of persistence in patients with predicted high likelihood of benefit.
Article
Oncology
Shoshana M. Rosenberg, Yue Zheng, Shari Gelber, Kathryn J. Ruddy, Philip Poorvu, Tal Sella, Rulla M. Tamimi, Johanna Wassermann, Lidia Schapira, Virginia F. Borges, Steven Come, Jeffrey Peppercorn, Karen R. Sepucha, Ann H. Partridge
Summary: This study aims to understand the non-initiation and non-persistence of oral adjuvant endocrine therapy (ET) in young women with breast cancer and propose corresponding interventions. The results showed that black women were more likely to have non-initiation, while women with a college degree were more likely to initiate treatment. Non-persistence was associated with younger age, being married/partnered, and having more weight problems. After adjusting for age and clinical characteristics, non-persistence was associated with lower odds of recurrence.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Caitriona Cahir, Kathleen Bennett, Stephan U. Dombrowski, Catherine M. Kelly, Mary Wells, Eila Watson, Linda Sharp
Summary: To develop intervention for endocrine therapy (ET) non-adherence in women with breast cancer, this study measured modifiable determinants using Theoretical Domains Framework (TDF) and examined their relationships using Perceptions and Practicalities Approach (PAPA). The final model explained 59% of non-adherence variance and had an acceptable fit. Knowledge mediated non-adherence through beliefs about consequences and capabilities. Illness intrusiveness mediated non-adherence through beliefs about consequences. Beliefs about consequences mediated non-adherence through memory, attention, decision processes, and environment.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Cynthia Villarreal-Garza, Fernanda Mesa-Chavez, Ana S. Ferrigno, Cynthia De la Garza-Ramos, Alan Fonseca, Karen Villanueva-Tamez, Jose Y. Campos-Salgado, Marlid Cruz-Ramos, David O. Rodriguez-Gomez, Sandy Ruiz-Cruz, Paula Cabrera-Galeana
Summary: The study showed that premenopausal Mexican women with breast cancer exhibit high rates of adherence to endocrine therapy, but some patients still struggle with adherence due to forgetfulness, adverse effects, and unwillingness to take medication. However, there is room for improvement in physician prescribing practices, as some patients did not receive the guideline-endorsed regimens.
Editorial Material
Oncology
Niamh C. Cunningham, Nicholas C. Turner
Summary: CDK4/6 inhibitors have shown consistent efficacy in the treatment of metastatic breast cancer, but recent adjuvant trials for early stage breast cancer have produced conflicting results, highlighting the need for further research on their clinical utility and future trial design.
Review
Oncology
Kirsti I. Toivonen, Tamara M. Williamson, Linda E. Carlson, Lauren M. Walker, Tavis S. Campbell
Summary: The study found that self-efficacy and positive decisional balance were the most consistently associated modifiable factors with AET adherence or persistence. Side effects were less likely to be associated with adherence compared to other factors. Therefore, focusing on self-efficacy and decisional balance may be relevant for interventions to improve AET adherence among breast cancer survivors.
Article
Oncology
Yasemin Uslu, Vildan Kocatepe, Derya Subasi Sezgin, Cihan Uras
Summary: The purpose of this study was to investigate adjuvant tamoxifen adherence and associated factors in breast cancer survivors. The results showed that overall, breast cancer survivors in the study had moderate adherence to tamoxifen. Individual characteristics and treatment-related adverse effects influenced medication adherence. Healthcare professionals can increase adherence to this treatment by explaining its importance, addressing barriers to adherence, and providing evidence-based interventions.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Clinical
Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Sing Huang Tan, Li En Yvonne Ang, Siew Eng Lim, Wan Qin Chong, Jingshan Ho, Soo Chin Lee, Bee Choo Tai
Summary: The study validated the Beliefs about Medicines Questionnaire (BMQ) and Adherence Starts with Knowledge (ASK-12) questionnaire for use in a Singapore population with early stage breast cancer. The new factor structure obtained from exploratory factor analysis improved the internal consistency of BMQ-General and ASK-12 Behaviour scale. Further studies are required to confirm these factor structures.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Editorial Material
Oncology
Elizabeth J. Cathcart-Rake, Tara Sanft, Amye J. Tevaarwerk
Summary: Sella and colleagues shed light on the potential mechanisms underlying weight changes for young survivors after breast cancer diagnosis. However, policy and regulatory changes are necessary to target modifiable determinants of health and implement practical, sustainable interventions based on this information.
Article
Oncology
Marc A. Emerson, Ninah S. Achacoso, Halei C. Benefield, Melissa A. Troester, Laurel A. Habel
Summary: The study found that American Indian/Alaska Native (AIAN) women enrolled in the KPNC health system have lower rates of initiation and adherence to adjuvant endocrine therapy (AET) compared to other races/ethnicities.
Review
Oncology
Inga Bekes, Jens Huober
Summary: Seventy percent of breast cancer subtypes are hormone receptor-positive, and adjuvant endocrine therapy is crucial for these patients. Extending adjuvant endocrine therapy beyond 5 years has been shown to reduce the risk of late recurrence, but the optimal duration is still debated. Newer data suggest only marginal benefits beyond 7 to 10 years, and longer duration may result in more side effects. Therefore, it is important to select patients who qualify for extended therapy based on genomic tests and risk assessment.
Article
Oncology
Haoran Jiang, Ai-ping Wang, Hui Xu, Ye Liu, Yu Dong, Yuanhui Sun, Shuqin Li
Summary: This study examined the relationship between family support, serum lipid knowledge, and quality of life in breast cancer women undergoing endocrine therapy. The results showed that good family support was associated with better serum lipid knowledge and higher quality of life. Disease stage, family support, and serum lipid knowledge were identified as influencing factors for the quality of life in these patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Olivia Pagani, Barbara A. Walley, Gini F. Fleming, Marco Colleoni, Istvan Lang, Henry L. Gomez, Carlo Tondini, Harold J. Burstein, Matthew P. Goetz, Eva M. Ciruelos, Vered Stearns, Herve R. Bonnefoi, Silvana Martino, Charles E. Geyer, Claudio Chini, Fabio Puglisi, Simon Spazzapan, Thomas Ruhstaller, Eric P. Winer, Barbara Ruepp, Sherene Loi, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Meredith M. Regan, Prudence A. Francis
Summary: The combined analysis of SOFT-TEXT compared the outcomes of 4,690 premenopausal women with ER/PgR+ early breast cancer randomly assigned to exemestane + OFS or tamoxifen + OFS. Exemestane + OFS showed significant improvement in DFS and DRFI, but not overall survival, compared to tamoxifen + OFS. This study provides guidance for selecting patients who may benefit from exemestane over tamoxifen in the setting of OFS.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychology, Clinical
Jennifer E. Vaughn, Chesley Ammerman, Maryam B. Lustberg, Warren K. Bickel, Jeffrey S. Stein
Summary: The study indicates that delay discounting (DD) is associated with medication adherence in breast cancer patients, especially in terms of pill count. Interventions such as episodic future thinking (EFT) can significantly reduce DD.
Article
Oncology
Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Sing Huang Tan, Li En Yvonne Ang, Siew Eng Lim, Wan Qin Chong, Jingshan Ho, Soo Chin Lee, Bee Choo Tai
Summary: Older age and lower barriers to adherence were associated with higher adherence scores. Necessity-concerns beliefs did not have a significant effect on adherence as majority of the patients identified forgetfulness as a reason for non-adherence.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Candyce H. Kroenke, Carla M. Prado, Jeffrey A. Meyerhardt, Erin K. Weltzien, Jingjie Xiao, Elizabeth M. Cespedes Feliciano, Bette J. Caan
Article
Oncology
Candyce H. Kroenke, Electra D. Paskett, Crystal W. Cene, Bette J. Caan, Juhua Luo, Aladdin H. Shadyab, Jamaica R. M. Robinson, Rami Nassir, Dorothy S. Lane, Garnet L. Anderson
Article
Multidisciplinary Sciences
Candyce H. Kroenke, Gem M. Le, Shannon M. Conroy, Alison J. Canchola, Salma Shariff-Marco, Scarlett Lin Gomez
Article
Oncology
Yuan Yuan, Kathy Pan, Joanne Mortimer, Rowan T. Chlebowski, Juhua Luo, Jessica E. Yan, Susan E. Yost, Candyce H. Kroenke, Lucile Adams-Campbell, Rami Nassir, Yangbo Sun, Aladdin H. Shadyab, Mara Z. Vitolins, Nazmus Saquib, Robert A. Wild, JoAnn E. Manson, Rebecca A. Nelson
Summary: In postmenopausal women with triple-negative breast cancer and 3 or 4 MetS risk components, there is a significantly higher risk of breast cancer-specific mortality and overall mortality, indicating the negative impact of metabolic risk factors on mortality outcomes.
Article
Oncology
Rhonda-Lee F. Aoki, Stephen P. Uong, Scarlett Lin Gomez, Stacey E. Alexeeff, Bette J. Caan, Lawrence H. Kushi, Jacqueline M. Torres, Alice Guan, Alison J. Canchola, Brittany N. Morey, Katherine Lin, Candyce H. Kroenke
Summary: The study found that low neighborhood-level socioeconomic status is significantly associated with LumB and TNBC subtypes, while individual education is only associated with the Her2-e subtype, and individual income is not significantly associated with any breast cancer subtype.
Article
Geriatrics & Gerontology
Hayami K. Koga, Claudia Trudel-Fitzgerald, Lewina O. Lee, Peter James, Candyce Kroenke, Lorena Garcia, Aladdin H. Shadyab, Elena Salmoirago-Blotcher, JoAnn E. Manson, Francine Grodstein, Laura D. Kubzansky
Summary: Research has found a link between optimism and healthy aging and exceptional longevity, but this association may vary across different racial and ethical groups. Lifestyle factors partially mediate the association between optimism and lifespan.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Psychology, Multidisciplinary
Melissa Flores, John M. Ruiz, Emily A. Butler, David A. Sbarra, David O. Garcia, Lindsay Kohler, Tracy E. Crane, Giselle Corbie-Smith, Viola Benavente, Candyce H. Kroenke, Nazmus Saquib, Cynthia A. Thomson
Summary: This study found that older Hispanic women have a higher survival rate compared to non-Hispanic Whites and other racial-ethnic groups, after controlling for socioeconomic status and health controls. Despite a higher divorce rate, Hispanics did not show a significant interactive effect of race-ethnicity and marital status on survival.
ANNALS OF BEHAVIORAL MEDICINE
(2021)