Article
Multidisciplinary Sciences
Miaomiao Zhao, Yan Zheng, Jian Chu, Zhenhua Liu, Fenglin Dong
Summary: This study developed a novel non-invasive method to predict sentinel lymph node metastasis in breast cancer by analyzing ultrasound imaging characteristics and peripheral blood T-cell subsets. The constructed combined model showed good performance and can be used to guide clinical decisions in breast surgery.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Yasuhisa Hasegawa, Kiyoaki Tsukahara, Seiichi Yoshimoto, Kouki Miura, Junkichi Yokoyama, Shigeru Hirano, Hirokazu Uemura, Masashi Sugasawa, Tomokazu Yoshizaki, Akihiro Homma, Kazuaki Chikamatsu, Mikio Suzuki, Akihiro Shiotani, Takashi Matsuzuka, Naoyuki Kohno, Masakazu Miyazaki, Isao Oze, Keitaro Matsuo, Shigeru Kosuda, Yasushi Yatabe
Summary: The study showed that sentinel lymph node biopsy may replace elective neck dissection in the treatment of early oral cavity squamous cell carcinoma without a survival disadvantage, and it can reduce postoperative neck disability.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Malvika H. Solanki, Arielle P. Stafford, Judy C. Boughey, Tina J. Hieken
Summary: Immunohistochemistry (IHC) improves the detection of pN0(i+) disease in invasive lobular carcinoma (ILC) patients undergoing sentinel lymph node (SLN) surgery, but does not increase nodal upstaging, the number of positive SLNs detected, or axillary lymph node dissection (ALND) rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Carl-Jacob Holmberg, Rasmus Mikiver, Karolin Isaksson, Christian Ingvar, Marc Moncrieff, Kari Nielsen, Lars Ny, Johan Lyth, Roger Olofsson Bagge
Summary: This study aimed to determine whether sentinel lymph node status has prognostic value in T4 melanoma tumors. The results showed a significant difference in survival rates between patients with positive and negative sentinel lymph nodes, suggesting the importance of updating clinical guidelines to reflect this finding.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Shan Yang, Hong-Yu Xiang, Ling Xin, Hong Zhang, Shuang Zhang, Yuan-Jia Cheng, Qian Liu, Ling Xu, Ting Li, Xue-Ning Duan, Jing-Ming Ye, Yin-Hua Liu
Summary: This study retrospectively analyzed the clinicopathological data of patients with early breast cancer treated at Peking University First Hospital between 2013 and 2018, finding that methylene blue as the commonly used tracer in sentinel lymph node biopsy in China has acceptable identification rate and low false-negative rate, while patients with non-SLN metastasis have poor prognosis.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Gilles Houvenaeghel, Monique Cohen, Pedro Raro, Jeremy De Troyer, Pierre Gimbergues, Christine Tunon de Lara, Vivien Ceccato, Veronique Vaini-Cowen, Christelle Faure-Virelizier, Frederic Marchal, Tristan Gauthier, Eva Jouve, Pierrick Theret, Claudia Regis, Philippe Gabelle, Julia Pernaut, Francesco Del Piano, Gauthier D'Halluin, Stephane Lantheaume, Emile Darai, Bassoodeo Beedassy, Caroline Dhainaut-Speyer, Xavier Martin, Sophie Girard, Richard Villet, Emilie Monrigal, Theophile Hoyek, Jean-Francois Le Brun, Pierre-Emmanuel Colombo, Agnes Tallet, Jean-Marie Boher
Summary: The study analyzed the treatment and pathological results of patients included in the SERC trial, a multicenter randomized non-inferiority phase-3 trial comparing completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy alone in breast cancer patients. Patients with one or two involved sentinel nodes by micro- or macro-metastases may not require cALND, but further research is needed for those with more than two involved nodes.
Article
Medicine, General & Internal
Piotr Kedzierawski, Artur Bocian, Agnieszka Radowicz-Chil, Anna Huruk-Kuchinka, Ryszard Mezyk
Summary: The purpose of this study was to determine the correlation between the biological subtype of breast cancer and the risk of metastasis to a sentinel lymph node. In the analyzed group of 1018 women with breast cancer, 57% were classified as Luminal A subtype. A positive sentinel lymph node was found in 26.5% of the women.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Surgery
Fulong Chen, Xiaowen Li, Xianjun Lin, Lijia Chen, Zhaoling Lin, Hao Wu, Jishang Chen
Summary: This meta-analysis examined the role of axillary lymph node dissection (ALND) in breast cancer patients with positive sentinel lymph nodes (SLNs) undergoing mastectomy. The results showed that performing ALND in patients with limited SLN metastases was associated with certain clinicopathological factors, but it did not significantly improve survival outcomes. Further randomized clinical trials are needed to confirm these findings.
WORLD JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Hakan Balbaloglu, Ilhan Tasdoven, Guldeniz Karadeniz Cakmak
Summary: This study investigated the value of inflammatory indices in predicting positive sentinel nodes in breast cancer and analyzed data from 602 breast cancer patients. The results showed that inflammatory indices did not affect the prediction of sentinel lymph node biopsy results, contrary to previous research.
Article
Oncology
Patrice Mathevet, Benedetta Guani, Andrea Ciobanu, Eliane Mery Lamarche, Florent Boutitie, Vincent Balaya, Fabrice Lecuru
Summary: The pelvic SLN technique is proven to be safe and reliable for nodal status assessment in patients with early-stage cervical cancer, with a 100% negative predictive value (NPV) in cases of bilateral detection without false-negatives.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Shih-Chiang Huang, Chi-Chung Chen, Jui Lan, Tsan-Yu Hsieh, Huei-Chieh Chuang, Meng-Yao Chien, Tao-Sheng Ou, Kuang-Hua Chen, Ren-Chin Wu, Yu-Jen Liu, Chi-Tung Cheng, Yu-Jen Huang, Liang-Wei Tao, An-Fong Hwu, I-Chieh Lin, Shih-Hao Hung, Chao-Yuan Yeh, Tse-Ching Chen
Summary: The study presents an artificial-intelligence-assisted workflow for lymph node metastasis assessment, which significantly improves the sensitivity of micrometastasis and isolated tumor cells identification in gastric cancer, while reducing review time. Trained on high-resolution images, the algorithm demonstrates high accuracy in identifying metastatic LNs, showing robustness in cross-site evaluation.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Anastasia Bothou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Georgia Margioula-Siarkou, Stefanos Zervoudis, Alexandros Sotiriadis, Frederic Amant, Konstantinos Dinas
Summary: Sentinel lymph node biopsy (SLNB) appears to be a safe and effective technique for breast cancer during pregnancy, according to this systematic review. A total of 63 articles were included, with 47 strongly in favor of SLNB in pregnancy-related breast cancer (PABC), 4 partially in favor, 10 strongly against, and 2 partially against. Sub-categorization based on study type showed that the majority of studies in favor had higher levels of evidence. In total, 382 women with PABC underwent SLNB, and full data were reported for 237 cases. The overall live birth rate was 95.8%, while the overall neonatal complication rate was 3.4%. No cases of maternal side effects or anaphylactic reaction, maternal death, stillbirth, or neonatal death were reported (0%).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Florian Fitzal, Michael Bolliger, Daniela Dunkler, Angelika Geroldinger, Luca Gambone, Joerg Heil, Fabian Riedel, Jana de Boniface, Camilla Andre, Zoltan Matrai, David Pukancsik, Regis R. Paulinelli, Valerijus Ostapenko, Arvydas Burneckis, Andrej Ostapenko, Edvin Ostapenko, Francesco Meani, Yves Harder, Marta Bonollo, Andrea S. M. Alberti, Christoph Tausch, Baerbel Papassotiropoulos, Ruth Helfgott, Dietmar Heck, Hans-Joerg Fehrer, Markus Acko, Peter Schrenk, Elisabeth K. Trapp, Pristauz-Telsnigg Gunda, Paliczek Clara, Giacomo Montagna, Mathilde Ritter, Jens-Uwe Blohmer, Sander Steffen, Laszlo Romics, Elizabeth Morrow, Katharina Lorenz, Mathias Fehr, Walter Paul Weber
Summary: Recent data suggest that larger resection volumes in oncoplastic surgery, such as OBCII, may improve local control and reduce reexcision rates significantly compared to conventional breast conserving surgery (BCS) or oncoplastic breast conservation with lower resection volumes (OBCI). Despite differences in tumor size and resection margins, there were no differences in local, regional, or distant recurrence-free or overall survival between patients treated with OBCII and those treated with BCS/OBCI.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Letter
Surgery
Jana de Boniface, Robert Szulkin, Anna L. V. Johansson
Meeting Abstract
Oncology
F. Ruf, T. Kuehn, S. Hartmann, J. de Boniface, O. D. Gentilini, E. Stickeler, G. K. Cakmak, I. Rubio, L. Niinikoski, M. Kontos, D. Murawa, E-A. Bonci, M. Hauptmann, M. Thill, H. Markus, M. P. Lux, M. Appelgren, J-U. Blohmer, M. Untch, M. Banys-Paluchowski
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Matilda Appelgren, Helena Sackey, Yvonne Wengstrom, Karin Johansson, Johan Ahlgren, Yvette Andersson, Leif Bergkvist, Jan Frisell, Dan Lundstedt, Lisa Ryden, Malin Sund, Sara Alkner, Birgitte Vrou Offersen, Tove Filtenborg Tvedskov, Peer Christiansen, Jana de Boniface
Summary: This report evaluates the impact of axillary lymph node dissection (ALND) on health related quality of life (HRQoL) and patient-reported arm morbidity one year after breast cancer surgery. The study found that ALND did not have a negative impact on HRQoL and could reduce arm morbidity in patients.
Article
Oncology
Walter Paul Weber, Jane Shaw, Andrea Pusic, Lynda Wyld, Monica Morrow, Tari King, Zoltan Matrai, Joerg Heil, Florian Fitzal, Shelley Potter, Isabel T. Rubio, Maria-Joao Cardoso, Oreste Davide Gentilini, Viviana Galimberti, Virgilio Sacchini, Emiel J. T. Rutgers, John Benson, Tanir M. Allweis, Martin Haug, Regis R. Paulinelli, Tibor Kovacs, Yves Harder, Bahadir M. Gulluoglu, Eduardo Gonzalez, Andree Faridi, Elisabeth Elder, Peter Dubsky, Jens-Uwe Blohmer, Vesna Bjelic-Radisic, Mitchel Barry, Susanne Dieroff Hay, Kimberly Bowles, James French, Roland Reitsamer, Rupert Koller, Peter Schrenk, Daniela Kauer-Dorner, Jorge Biazus, Fabricio Brenelli, Jaime Letzkus, Ramon Saccilotto, Sarianna Joukainen, Susanna Kauhanen, Ulla Karhunen-Enckell, Juergen Hoffmann, Ulrich Kneser, Thorsten Kuhn, Michalis Kontos, Ekaterini Christina Tampaki, Moshe Carmon, Tal Hadar, Giuseppe Catanuto, Carlos A. Garcia-Etienne, Linetta Koppert, Pedro F. Gouveia, Jakob Lagergren, Tor Svensjoe, Nadia Maggi, Elisabeth A. Kappos, Fabienne D. Schwab, Liliana Castrezana, Daniel Steffens, Janna Krol, Christoph Tausch, Andreas Gunthert, Michael Knauer, Maria C. Katapodi, Susanne Bucher, Nik Hauser, Christian Kurzeder, Rosine Mucklow, Pelagia G. Tsoutsou, Atakan Sezer, Guldeniz Karadeniz Cakmak, Hasan Karanlik, Patricia Fairbrother, Laszlo Romics, Giacomo Montagna, Cicero Urban, Melanie Walker, Silvia C. Formenti, Guenther Gruber, Frank Zimmermann, Daniel Rudolf Zwahlen, Sherko Kuemmel, Mahmoud El-Tamer, Marie Jeanne Vrancken Peeters, Orit Kaidar-Person, Michael Gnant, Philip Poortmans, Jana de Boniface
Summary: The aim of this article is to discuss the demand for nipple-and skin-sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) and present clinical practice recommendations in the context of expanded indications for post-mastectomy radiation therapy (PMRT). The panel agrees that surgical technique for NSM/SSM should not be modified when PMRT is planned, with preference for autologous over implant-based BR. However, no specific recommendations are made regarding implant positioning, use of mesh or timing. The use of patient-reported outcomes in clinical practice is endorsed. The article emphasizes the importance of prospective randomized phase III studies and interdisciplinary collaboration for determining optimal sequencing and techniques for PMRT in the context of BR.
Article
Oncology
Jana de Boniface, Jan Frisell, Thorsten Kuehn, Ingrid Wiklander-Brakenhielm, Karin Dembrower, Per Nyman, Athanasios Zouzos, Bernd Gerber, Toralf Reimer, Steffi Hartmann
Summary: In clinically node-positive breast cancer patients, carbon tattooing is a low-cost marking method with a high detection rate and acceptably low false-negative rate.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
Maria Luisa Gasparri, Jana De Boniface, Oreste Davide Gentilini, Orit Kaidar-Person, Philip Poortmans, Thorsten Kuehn
Meeting Abstract
Oncology
Thorsten Kuhn, Steffi Hartmann, Elmar Stickeler, Jana de Boniface, Oreste Gentilini, Sarah Frohlich, Franziska Ruf, Marc Thill, Michael Hauptmann, Guldeniz Karadeniz Cakmak, Isabel Rubio, Maria Luisa Gasparri, Michaelis Kontos, Eduard-Alexandru Bonci, Laura Niinikoski, Rosa Di Micco, Dawid Murawa, David Pinto, Florentia Peintinger, Christine Solbach, Matilda Appelgren, Jens-Uwe Blohmer, Michael Weigel, Gabriele Kaltenecker, Michael Schrauder, Janine Simons, Marjolein Smidt, Ellen Schlichting, Lukas Dostalek, Alexander Sergeevich Emelyanov, Elisabeth Thiemann, Semra Gunay, Sybille Loibl, Maggie Banys-Paluchowski
Article
Surgery
A. Frisell, O. Bergman, A. Khan, A. Gistera, R. M. Fisher, J. Lagergren, J. de Boniface, M. Halle
Summary: We conducted a comparative study of gene expression patterns in capsular tissue from breast cancer patients who had received radiation therapy after implant-based immediate breast reconstruction. The results revealed that there were inflammatory responses in capsular biopsies regardless of radiotherapy, but radiation specifically increased B-cell-associated inflammatory responses.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Jana de Boniface, Renske Altena, Cecilia Haddad Ringborg, Kate A. Bolam, Yvonne Wengstrom
Summary: Physical exercise after neoadjuvant chemotherapy may improve pathological complete response (pCR) rates in breast cancer patients.
Review
Surgery
Maggie Banys-Paluchowski, Jana de Boniface
Summary: In recent years, there have been rapid changes in the axillary staging of breast cancer patients who initially had positive lymph nodes but converted to clinical node negativity after neoadjuvant chemotherapy. This review provides an overview of the published evidence and clinical practice, with the aim of guiding surgical practitioners in re-evaluating and reshaping their surgical approach. The introduction of modern techniques has allowed for more precise staging surgery, potentially reducing arm morbidity. However, there is significant variation in clinical practices both within countries and internationally, and questions remain regarding the safety, performance, budget, practicality, patient selection, and indications of different levels of axillary staging procedures.
SCANDINAVIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Steffi Hartmann, Maggie Banys-Paluchowski, Elmar Stickeler, Jana de Boniface, Oreste Davide Gentilini, Michalis Kontos, Stephan Seitz, Gabriele Kaltenecker, Fredrik Waernberg, Linda Holmstrand Zetterlund, Hans-Christian Kolberg, Sarah Froehlich, Thorsten Kuehn
Summary: This study investigates the feasibility of using magnetic seeds (MS) to mark and selectively remove suspicious axillary lymph nodes in breast cancer patients. The results show that MS inserted before neoadjuvant chemotherapy have a high detection rate and low marker loss rate, but may impair the magnetic resonance imaging assessment of the breast.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Surgery
Jana de Boniface, Robert Szulkin, Anna L. Johansson
Summary: Older women with breast cancer have a higher risk of major medical complications after surgery, especially those who undergo mastectomy. The removal of the whole breast is associated with a higher risk of complications and worse survival in older patients. Mastectomy should be considered with caution in older women.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Obstetrics & Gynecology
Maggie Banys-Paluchowski, Michael Untch, Natalia Krawczyk, Maria Thurmann, Thorsten Kuehn, Jalid Sehouli, Maria Luisa Gasparri, Jana de Boniface, Oreste Davide Gentilini, Elmar Stickeler, Nina Ditsch, Achim Rody, Peter Paluchowski, Jens-Uwe Blohmer
Summary: This study investigated the current approach to axillary management in breast cancer patients receiving neoadjuvant chemotherapy in Germany. The survey revealed heterogeneity in the recommendations for different patient groups, but the majority of respondents still follow current guidelines. Furthermore, there is a need for comparative evaluation of different marking techniques.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)